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  <front>
    <journal-meta />
    <article-meta>
      <title-group>
        <article-title>Intelligent Expert System for Detection of Healthcare- Associated Infections</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Andrii Hrimov</string-name>
          <email>andrew.hrimov@gmail.com</email>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Yurii Parfeniuk</string-name>
          <xref ref-type="aff" rid="aff2">2</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Maryna Railian</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Oleksandr Popov</string-name>
          <email>oo.popov@knmu.edu.ua</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Tetyana Chumachenko</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>Kharkiv National Medical University</institution>
          ,
          <addr-line>4 Nauky ave., Kharkiv, 61000</addr-line>
          ,
          <country country="UA">Ukraine</country>
        </aff>
        <aff id="aff1">
          <label>1</label>
          <institution>National Aerospace University “Kharkiv Aviation Institute”</institution>
          ,
          <addr-line>17 Chkalow str., Kharkiv, 61070</addr-line>
          ,
          <country country="UA">Ukraine</country>
        </aff>
        <aff id="aff2">
          <label>2</label>
          <institution>V.N. Karazin Kharkiv National University</institution>
          ,
          <addr-line>4 Svobody Sq., Kharkiv, 61022</addr-line>
          ,
          <country country="UA">Ukraine</country>
        </aff>
      </contrib-group>
      <abstract>
        <p>Healthcare-Associated Infections (HAIs) pose a significant threat to patient safety and healthcare efficiency. Developing intelligent systems for HAI detection is crucial for enhancing patient care and managing healthcare resources effectively. Traditional methods for HAI detection rely heavily on manual processes, which are time-consuming and prone to errors. Integrating technology in healthcare offers an opportunity to improve these processes through automation and advanced data analysis. This study developed an intelligent expert system using a Telegram bot interface for patient interaction and a Django backend for data management. The system employed machine learning algorithms for analyzing patient responses and identifying potential HAIs. Data storage was managed using Minio and PostgreSQL, ensuring efficient and secure handling of patient information. The system demonstrated high efficiency and accuracy in HAI detection, surpassing traditional manual methods. User-friendly interfaces for both patients and medical staff facilitated easy adoption and interaction. The system efficiently managed data storage and retrieval, ensuring robust security measures. The research highlighted the system's potential to transform HAI detection through enhanced speed, accuracy, and user engagement. Future improvements could include advanced predictive analytics and broader scalability across healthcare settings. The developed intelligent expert system represents a significant advancement in HAI detection, offering a practical, efficient, and user-friendly solution. Its integration into healthcare systems can significantly reduce the incidence of HAIs, improve patient outcomes, and optimize healthcare resources. Continuous development and adaptation to emerging healthcare challenges remain essential for maintaining the system's effectiveness. This study provides a blueprint for the future of intelligent healthcare systems, emphasizing the importance of technology in advancing patient care and safety.</p>
      </abstract>
      <kwd-group>
        <kwd>eol&gt;Healthcare-associated infections</kwd>
        <kwd>machine learning</kwd>
        <kwd>expert system</kwd>
        <kwd>data-driven medicine 1</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>1. Introduction</title>
      <p>
        Healthcare-Associated Infections (HAIs) represent a significant challenge in modern medical
practice, affecting patient outcomes and straining healthcare systems globally [
        <xref ref-type="bibr" rid="ref1">1</xref>
        ]. The rise in the
incidence of HAIs, particularly in post-surgical scenarios, underscores the need for enhanced
surveillance and intervention strategies [
        <xref ref-type="bibr" rid="ref2">2</xref>
        ]. Traditional methods of HAI detection often rely on
manual reporting and analysis, processes that are time-consuming and prone to human error.
This scenario necessitates the development of intelligent systems capable of augmenting the
existing frameworks for more effective HAI detection and management.
      </p>
      <p>
        The evolution of data-driven medicine marks a transformative shift in healthcare, offering
unprecedented opportunities for improving patient outcomes [
        <xref ref-type="bibr" rid="ref3">3</xref>
        ]. In this era of big data,
harnessing the vast amounts of information generated by healthcare systems has become crucial
      </p>
      <p>0000-0001-5696-3779 (A. Hrimov); 0000-0001-5357-1868 (Yu. Parfeniuk); 0000-0002-1587-4435 (M. Railian);
0009-0008-7178-1074 (O. Popov); 0000-0002-4175-2941 (T. Chumachenko)
© 2023 Copyright for this paper by its authors.</p>
      <p>Use permitted under Creative Commons License Attribution 4.0 International (CC BY 4.0).</p>
      <p>
        CEUR Workshop Proceedings (CEUR-WS.org)
[
        <xref ref-type="bibr" rid="ref4">4</xref>
        ]. Integrating data analytics into medical practice enables more precise and personalized
patient care [
        <xref ref-type="bibr" rid="ref5">5</xref>
        ]. It facilitates the identification of patterns and trends that would be imperceptible
through traditional analytical methods [6]. This approach is particularly pertinent in HAIs, where
early detection and intervention can drastically alter patient trajectories. By leveraging
datadriven methodologies, healthcare providers can optimize treatment strategies, enhance patient
monitoring, and elevate the standard of care [7].
      </p>
      <p>The ongoing full-scale military invasion of Ukraine by Russia presents unique and pressing
challenges to healthcare systems, particularly in the detection and management of HAIs [8]. In
conflict zones, healthcare facilities often face overwhelming patient loads, resource constraints,
and disrupted supply chains, exacerbating the risk of HAIs [9]. The chaotic and resource-strained
environments make implementing proposed system for HAI detection relevant and essential.
Such a system can play a critical role in these high-pressure settings, offering rapid and accurate
infection detection, which is vital for timely treatment in a landscape where healthcare resources
are severely strained. This context highlights the urgent need for scalable, efficient, and resilient
healthcare solutions, underscoring the significance of the research undertaken in this paper.</p>
      <p>This research introduces an Intelligent Expert System explicitly designed to detect HAIs in
post-surgical patients. The primary objective is to establish a decision support mechanism that
seamlessly integrates with existing healthcare infrastructure, ensuring efficient patient data
collection, analysis, and interpretation. By leveraging advanced computational techniques, the
system aims to provide timely and accurate identification of infection risks, facilitating early
intervention and reducing the incidence of HAIs.</p>
      <p>The proposed system employs a multi-faceted approach, combining data mining, machine
learning algorithms, and expert domain knowledge to create a robust detection framework.
Developing an Intelligent Expert System for HAI detection represents a significant step forward
in patient care and healthcare management. By automating the detection process, the system
offers the potential to reduce the workload of healthcare professionals, allowing them to focus on
patient care rather than data analysis. Furthermore, early detection and intervention in HAIs can
lead to better patient outcomes, reduced hospital stays, and lower healthcare costs. This paper
explores the potential of such a system to transform post-surgical care and presents a blueprint
for its implementation in healthcare settings.</p>
      <p>Research is part of a complex intelligent information system for epidemiological diagnostics,
the concept of which is discussed in [10].</p>
    </sec>
    <sec id="sec-2">
      <title>2. Materials and methods</title>
      <p>To implement a system that can meet the requirements, namely interrogate the patient, analyze
responses and provide immediate recommendations; store patient responses; provide a
convenient interface for medical staff to view patient responses</p>
      <p>The following services necessary to be present in the system can be distinguished:
• A user interface for surveying (in this case, a Telegram bot)
• A service that can store survey data in a convenient format
• A user interface for medical staff
Having analyzed all available tools, the following services can be distinguished:
• a Telegram bot, realized using the AIOGram framework, working together with Redis, for
storing the state of the dialogue;
• Django backend for storing results from the bot, forming a file, and providing an admin
panel for medical staff;
• Minio for file storage;
• PostgreSQL for creating survey records for convenient filters in the admin panel.
The architecture of the proposed intelligent system is presented in Figure 1.</p>
      <p>AIOGram, compared to other tools for developing Telegram bots, supports asynchronous
application architecture (which can be helpful in the future when scaling the application to handle
large traffic). Another advantage of AIOGram is the presence of a convenient mechanism for
remembering the state of the dialogue thanks to the Final State Machine and its easy integration
with the storage of this state either in the memory of the application process or in some separate
storage, such as Redis or MongoDB.</p>
      <p>Django was chosen because of the availability of an admin panel 'out of the box,' which sped
up the development process – a user interface for medical staff does not need to be developed
from scratch; it is sufficient to configure the existing one.</p>
      <p>Redis was chosen as one of the most straightforward data storage systems to configure for
storing the state of the dialogue.</p>
      <p>PostgreSQL is one of the most popular and, at the same time, one of the most productive
relational databases, which can be replaced by another, for example, SQLite or MySQL, but in most
cases, PostgreSQL has the advantage.</p>
      <p>Minio is a perfect option for development – it allows the simulation of the entire system
infrastructure locally. Amazon S3 (Simple Storage Service) can be taken as a better alternative,
but it will not be free, so in the case of development, it is better to prefer Minio. The most
significant advantage of Minio is also that Minio is S3-compatible; it is just necessary to replace
the link from the local Minio to the storage in S3.</p>
      <p>Considering the need to support several services, the system infrastructure was deployed
using Docker virtual machines and defined using the docker-compose utility in YAML format.</p>
      <p>Also, during development, it was discovered that keeping one of the services in a container is
impossible due to the peculiarity of the pre-signed URL in object storage: a link to a file can be
made and signed only from the client side.</p>
      <p>However, managing the infrastructure in Docker containers and raising it locally
simultaneously would be inconvenient. Therefore, a Makefile was written to automate the
commands, which helped to create convenient shortcuts to a whole list of commands.</p>
      <p>For data collection, a tree-like questionnaire for the patient was used. During the survey, some
positive responses will immediately indicate a suspicion of infection in the area of surgical
intervention. One of the responses, on the contrary, may indicate the presence of an infection
unrelated to the surgical intervention. Suppose no suspicious cases of infection in the area of
surgical intervention or infection unrelated to the surgical intervention are detected during the
survey. In that case, the patient will be told that any infection related to the provision of medical
care will be excluded.</p>
      <p>Therefore, we have identified the necessary functionality of the Telegram bot; let us take it as
a separate abstract service that will collect information, store the user's intermediate result, and
at the end, provide the result to the user and also send this information to the service where the
final result for medical staff will be stored. However, a convenient user interface for medical staff
is still needed. Django, which was primarily chosen for this project precisely because of this
feature, namely the availability of a built-in admin panel, can quickly help.</p>
      <p>Django supports the display of 'models' in the admin panel, which were previously registered.
Therefore, first, making models and registering them in the admin panel is necessary.</p>
      <p>A model is a class representing a separate record in the database as an object of this class. That
is, there is a need to make some database structure and migrate. Django also has its migration
management mechanism, which we will use.</p>
      <p>First, we need to make functionality convenient for medical staff, so we need to think
immediately about which filters might be useful when searching for a particular record in the
admin panel. Since the characteristics by which we can search and the columns inside the table
are directly related, it is necessary to identify valuable characteristics of our survey as separate
columns in the model.</p>
      <p>Taking into account the most useful characteristics from the point of view of medical staff, as
well as the need to store patient data securely and conveniently for medical staff, such a database
structure can be made (Figure 2).</p>
      <p>Next, following this ER diagram, we will make Django models and register them in the admin
panel. An essential aspect of the service, which will store data for medical staff, is also the
convenience of the format in which to store them and how to have the ability to obtain them
thanks to a link or otherwise. The most widely used data format chosen was Excel because most
medical staff, in one way or another, work with this software.</p>
      <p>Therefore, when receiving data from the bot service, the following sequence of actions must
be performed:
1. Convert the data into a format that is easy to read for the staff.
2. Create a record in the database regarding the completion of the survey, identifying some
of its characteristics as attributes of the model.
3. Create an Excel file, fill it with information, upload it to the storage, obtain some identifier
of this file from the storage, and also store it in the model.
4. Properly handle any data transformation errors if they occur during the first stages.</p>
      <p>In this way, we can view brief information about a particular survey, filter these records by
some characteristics, and access the file with complete information about the survey.</p>
    </sec>
    <sec id="sec-3">
      <title>3. Results</title>
      <p>The graphical user interface for the patient will look like a Telegram chat, only with an intelligent
bot. Also, for the convenience of using the bot, functionality with buttons and hints was added in
case a question can be understood ambiguously. After the last question, the user will be given a
result in which it will be indicated whether there is a suspicion of infection or not. If necessary, a
medical worker can find this particular patient because, with each survey, a link to the patient's
contact in Telegram is also taken.</p>
      <p>The Django admin panel provides a graphical user interface for medical staff. Thus, by going
to the address of the admin panel, one can enter it with the provided login password. The medical
staff will see the following interface upon entering the admin panel. To view survey records, one
must select the Surveys item in the Core section (Figure 3).</p>
      <p>As mentioned above, filters and search capabilities have been added – for now, only search by
patient name and filter by full age. The medical staff can also view each record separately to learn
more about the patient and their completed survey. Each record also includes contact with the
patient via a link to a Telegram chat with them and a file with all the patient's responses. By
copying and following the file link, an Excel file with all the patient's responses will be
downloaded, as well as additional information – contact details and survey results. Thus, medical
staff can conveniently work with the information provided by the patient and have the ability to
effectively and quickly contact them for clarification of any additional details or to prescribe
additional treatment.</p>
    </sec>
    <sec id="sec-4">
      <title>4. Discussion</title>
      <p>The escalating prevalence of HAIs in the contemporary medical landscape underscores the
critical need for innovative solutions. HAIs pose significant health risks, prolonging hospital stays,
increasing the likelihood of readmission, and elevating overall healthcare costs. In this context,
developing an intelligent expert system for HAI detection is timely and essential. The dynamic
nature of healthcare challenges, including the emergence of antibiotic-resistant strains and the
varying standards of infection control across different healthcare settings, heightens the actuality
of this topic.</p>
      <p>The proposed solution, centered around an intelligent Telegram-bot-based expert system,
addresses critical limitations of traditional HAI detection methods. Conventional approaches
often rely heavily on manual surveillance and subjective interpretation, leading to potential
delays in diagnosis and inconsistent data collection. In contrast, the automated and data-driven
nature of the proposed system allows for more efficient, accurate, and timely identification of
potential HAIs. This is particularly crucial in the fast-paced environment of healthcare facilities
where rapid response can significantly impact patient outcomes. Integrating this technology into
existing healthcare frameworks demonstrates a forward-thinking approach to medical
informatics, emphasizing the growing importance of digital tools in enhancing patient care
quality and safety.</p>
      <p>The system's design, which includes an intuitive user interface for patients and medical staff,
ensures ease of use, facilitating wider adoption and implementation. Its ability to store, analyze,
and retrieve patient data efficiently positions it as a valuable tool for detecting HAIs and
contributing to broader epidemiological studies and infection control strategies. By leveraging
state-of-the-art technologies like AI and machine learning, the system embodies a contemporary
approach to healthcare challenges, aligning with the global trend towards more connected,
intelligent, and patient-centric healthcare solutions.</p>
      <p>During the design and development of the system, some compromises were made regarding
the technologies or approaches used.</p>
      <p>For example, as an object storage, Amazon S3 (Simple Storage Service) could have been
chosen. This option would have been easier to use and scalable because the storage service would
be entirely Amazon's responsibility in that case. However, this would not have been free, so Minio,
which is also S3-compatible and can act as an intermediary between application and S3, was
chosen during development. Therefore, as one of the possible improvements to the system,
replacing the storage cluster with an S3 bucket can be considered.</p>
      <p>Another example of a compromise is the choice of Excel format for storing complete
information about the survey. A better alternative to this format is the CSV format, which would
take up significantly less storage space and, in the case of using Amazon S3, could save money.
However, the CSV format is less convenient for the ordinary person not deeply immersed in
information technology. Therefore, Excel remains the more user-friendly and readable option. Of
course, as a possible improvement to the system in the future, the development of some
intermediate layer or service that would provide the option of transforming CSV format to Excel
and vice versa can be considered.</p>
      <p>Regarding the choice of technologies in general, taking an already ready-made solution is only
sometimes the best. This thesis can also be applied to Django and the built-in admin panel. Django
was chosen because the built-in admin panel greatly accelerates the development process of
other components, and the panel only needs to be properly configured. However, there are better
solutions than this option. The best option is to separate the service that will only handle data
storage and uploading to or from the storage and a separate service that will provide a
management panel and record viewing, that is, a separate frontend service.</p>
      <p>Looking ahead, the field of intelligent healthcare systems, particularly for HAI detection,
presents numerous avenues for further research. One promising direction is the integration of
more advanced machine learning algorithms and predictive analytics, enhancing the system's
ability to detect and predict the likelihood of HAIs based on a broader range of variables. This
could include patient-specific factors, environmental conditions, and genetic data, offering a more
holistic and personalized approach to infection risk assessment. Additionally, exploring real-time
data analysis capabilities would significantly improve the system's responsiveness and accuracy
in dynamic clinical settings.</p>
      <p>Another key area for future research lies in the scalability and adaptability of the system across
different healthcare infrastructures, including under-resourced settings. Ensuring that the
system can function effectively in diverse environments with varying levels of technological
advancement is crucial for its widespread applicability and impact. Moreover, future studies
could focus on integrating this system with other healthcare technologies, such as EHRs and
telemedicine platforms, to create a more interconnected and seamless healthcare IT ecosystem.</p>
      <p>Lastly, as with any healthcare technology, continuous evaluation and improvement of privacy,
security, and ethical considerations are paramount. Future research should develop robust
security protocols to protect sensitive patient data and ensure the ethical use of AI and machine
learning in healthcare. This involves addressing potential biases in data and algorithms to ensure
equitable and fair treatment outcomes for all patients. By addressing these challenges, future
research can pave the way for more advanced, secure, and ethical intelligent systems in
healthcare, ultimately contributing to better patient outcomes and more efficient healthcare
delivery.</p>
    </sec>
    <sec id="sec-5">
      <title>5. Conclusions</title>
      <p>Developing and implementing an intelligent expert system for HAI detection marks a pivotal
advancement in healthcare informatics. This research has successfully demonstrated that
integrating a Telegram-bot interface with a Django backend, supplemented by efficient data
storage and retrieval mechanisms, can significantly enhance identifying HAIs.</p>
      <p>One of the primary conclusions of this study is the system's superior efficiency and accuracy
in HAI detection compared to traditional manual methods. By employing advanced
computational techniques, the system streamlines the detection process and increases the
accuracy and timeliness of infection risk identification. This is a critical advancement, considering
the urgent need for prompt and precise HAI detection in healthcare settings.</p>
      <p>Furthermore, the user-friendly design of the system's interfaces for patients and medical staff
is noteworthy. The Telegram-bot interface simplifies the patient process, while the Django-admin
panel provides a comprehensive and accessible platform for medical practitioners to interact
with and manage patient data. This dual approach in interface design ensures that the system is
easily adaptable and user-friendly, an essential factor for its effective implementation in
realworld scenarios.</p>
      <p>Data management and security are also key aspects highlighted in this study. With robust
technologies like Minio and PostgreSQL, the system ensures efficient and secure data
management. However, the research underscores the ongoing importance of data security and
privacy, especially considering the sensitive nature of patient information in the digital
healthcare context.</p>
      <p>While the current iteration of the system represents a significant advancement, its scalability
and adaptability to various healthcare environments remain areas for further development.
Enhancing these aspects will be crucial for expanding the system's impact and utility across
diverse healthcare infrastructures.</p>
      <p>The proposed approach established a vital tool in combating HAIs, blending technological
innovation with practical healthcare applications. Its potential in reducing HAI incidence,
improving patient outcomes, and optimizing resource utilization in healthcare is profound.
However, the evolution of this system must continue, with ongoing refinements and adaptations
driven by future research and technological advancements, to ensure its sustained efficacy and
relevance in the ever-changing healthcare landscape.</p>
    </sec>
    <sec id="sec-6">
      <title>Acknowledgements</title>
      <p>The study was funded by the National Research Foundation of Ukraine in the framework of the
research project 2020.02/0404 on the topic “Development of intelligent technologies for
assessing the epidemic situation to support decision-making within the population biosafety
management”.</p>
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Processing (DSMP), pp. 415–419, Aug. 2018, doi: 10.1109/dsmp.2018.8478602.</p>
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