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  <front>
    <journal-meta />
    <article-meta>
      <title-group>
        <article-title>Proof of clinical feasibility of natural language learning with machines</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Mihir Mulye</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Stefan Conrad</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Stefan Knecht</string-name>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>Institut für Informatik, Heinrich Heine University</institution>
          ,
          <addr-line>Düsseldorf</addr-line>
        </aff>
        <aff id="aff1">
          <label>1</label>
          <institution>Institut für Klinische Neurowissenschaften und Medizinische Psychologie</institution>
          ,
          <addr-line>Universitätsklinikum Düsseldorf</addr-line>
        </aff>
      </contrib-group>
      <abstract>
        <p>Aphasia is a condition resulting from a stroke or injury to the brain. This condition renders the patient unable to use language eficiently. Machine learning and artificial intelligence automate the assessment and diagnosis of aphasia to a certain extent. However, solutions based on machine learning that are patient-centric, self-paced, and help with therapy are lacking. In this work, we present a rehabilitation framework that can be implemented to address this deficit. As a part of an ongoing project, we aim to implement these ideas to facilitate the rehabilitation of aphasic patients by benefiting from the developments in machine learning. It is also anticipated that these ideas can be extended to help people wanting to acquire a new language.</p>
      </abstract>
      <kwd-group>
        <kwd>eol&gt;aphasia</kwd>
        <kwd>stroke</kwd>
        <kwd>machine learning (ML)</kwd>
        <kwd>artificial intelligence (AI)</kwd>
        <kwd>language rehabilitation</kwd>
        <kwd>people with aphasia (PWA)</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>1. Introduction</title>
      <p>bilitation framework that is easy to use, patient-centric,
self-paced, and attempts to utilize the advances in
maThe rapid advancements in machine learning and artifi- chine learning. We aim to design the framework and
cial intelligence have made it possible to solve diverse ofer the patients the possibility to practice as often and
problems. A particular use case in healthcare that has for as many iterations as they would like. We expect to
attracted the attention of researchers is the application eventually reduce the patients’ dependence on therapists
of machine learning approaches to manage aphasia. and provide more flexibility during rehabilitation.</p>
      <p>
        Aphasia is an acquired language disorder that can be The subsequent sections in this paper present the
caused by an injury to the brain, a stroke, or a result of related research, discussions regarding the approach
degenerative processes [
        <xref ref-type="bibr" rid="ref1 ref2">1, 2</xref>
        ]. This condition generally planned to be implemented throughout this project, and
impairs the afected person’s ability to speak, compre- the extent of implementation followed by future work.
hend, read, and write often to varying degrees [
        <xref ref-type="bibr" rid="ref2 ref3">2, 3</xref>
        ]. The final section concludes the discussion conducted in
People sufering from aphasia experience life-altering this paper.
psychosocial consequences such as reduced participation
in social settings, and diminished quality of life possibly
leading to psychological conditions such as anxiety and 2. Related work
depression [
        <xref ref-type="bibr" rid="ref4">4</xref>
        ]. Some patients are unable to function as
independent individuals as a consequence of this condition An overview of machine learning in aphasia
manage[
        <xref ref-type="bibr" rid="ref5">5</xref>
        ]. ment has been provided in [
        <xref ref-type="bibr" rid="ref2 ref6">2, 6</xref>
        ]. The discussions in
      </p>
      <p>
        Therapy and recovery to some extent are possible in these papers conclude that the majority of the works use
most cases. However, constraints such as a shortage of machine learning for the diagnosis and assessment of
therapists, availability of frequent therapy appointments aphasia. The authors highlight the need for exploring
for sustained recovery, and limited funding of support in- the possibility of utilizing the advancements in machine
frastructure for long-term rehabilitation programs prove learning to improve aphasia rehabilitation as well.
to be a hurdle [
        <xref ref-type="bibr" rid="ref2">2</xref>
        ]. Kohlschein et al., 2017 [
        <xref ref-type="bibr" rid="ref7">7</xref>
        ] propose an approach
us
      </p>
      <p>
        In this work, we discuss ideas as a part of an ongoing ing Bag of Audio Words and Long Short-Term Memory
project, that could be used to rehabilitate People With (LSTM) neural networks to automate the detection and
Aphasia (PWA). Our objective is to implement a reha- classification of aphasia speech. In this work, neural
networks are trained to identify the features corresponding
35th GI-Workshop on Foundations of Databases (Grundlagen von Daten- to aphasic speech and then classify the severity of
disabilbanken), May 22-24, 2024, Herdecke, Germany. ity based on the input audio sample. Similar to this work,
* Corresponding author. are approaches proposed by Hirsch et al., 2023 [
        <xref ref-type="bibr" rid="ref8">8</xref>
        ] and
† These authors contributed equally. Barbera et al. 2021 [9]. In these works, the authors utilize
$ mihir.mulye@uni-duesseldorf.de (M. Mulye); automatic speech recognition networks to categorize if
sstteeffaann..ckonnercahdt@@uunnii--dduueesssseellddoorrff..ddee ((SS.. KCnonecrhadt)); the uttered word is correct or incorrect compared to the
© 2024 Copyright for this paper by its authors. Use permitted under Creative Commons License ground truth. Mahmoud et al., 2021 [10] compare the
Attribution 4.0 International (CC BY 4.0).
performance of a neural network classifier and classical the therapy. The goal of this study was to forecast the
machine learning models such as Random Forests, Sup- individualized rehabilitation results.
port Vector Machines (SVM), and Linear Discriminant Das et al., 2022 [16] discuss the possibility of using
Analysis (LDA) among others to classify speech. Aphasic extended reality to help rehabilitate stroke patients. In
speech assessment was formulated as a speech classifica- particular, the authors predict that delivering speech
thertion task and the authors used three speech datasets: a apy via extended reality could be a helpful solution for
healthy speech dataset, an aphasic speech dataset, and a people with aphasia in an immersive setting.
combination of both. The authors reported that the neu- From the discussions of existing research work
conral network classifier outperformed the classical machine ducted in this section, we find that machine learning
learning classifiers on all three speech variants. approaches have been primarily used to assess, diagnose,
      </p>
      <p>
        Pierce et al., 2024 [11] explored an application of gen- and facilitate understanding of aphasia. However, a
syserative artificial intelligence to aphasia management. In tematic framework that is easy to use and focuses on
this work, the authors investigate the possibility of us- helping aphasic patients recover functionally in a
usering DALL-E, a powerful text-to-image model to create centric and self-paced manner using machine learning
images using text prompts. The authors aim to use the approaches is lacking [
        <xref ref-type="bibr" rid="ref6">6</xref>
        ].
generated images to assist therapists in assessing and
rehabilitating aphasia patients. The authors provide three
types of text prompts: nouns, verbs, and sentences. It is 3. Proposed approach
reported that the DALL-E model generates images for
nouns with the highest eficiency followed by verbs and In this section, we discuss an approach designed to help
sentences. This research concludes that improvements rehabilitate PWA. We provide an overview of the planned
in the text-to-image model quality will play a key role in approach, discuss the rehabilitation tasks required for
modifying aphasia assessment and rehabilitation. These therapy, establish the necessity for implementing
adapmodels will provide a means to accelerate the generation tive dificulty, and finally the possibility of expanding
of high-quality and low-cost images. this framework to acquire a new language.
      </p>
      <p>Research by Vong et al., 2024 [12] explored the
possibility of training a neural network using multi-modal data 3.1. Language learning framework
(visual and audio streams) to learn the word-referent map- We propose incorporating the tasks and activities [17]
pings. The data is collected from a camera mounted on that PWAs accomplish during their traditional therapy,
the head of a single child (aged between 6 to 25 months) into an online framework. To this end, we use the Flutter
thus providing approximately 61 hours of input streams toolkit based on the Dart programming language to
imfrom a first-person perspective to the neural network. plement this framework. This afords the possibility to
Though not directly related to aphasia management, this develop applications that run across multiple platforms.
approach presents interesting insights into how humans We intend to implement this framework as a gamified
acquire language and how this process can be adapted to platform. The basic Graphical User Interface (GUI)
dethe realm of machines. pends on the task being presented to the patients. The</p>
      <p>The work by Palmer et al., 2017 [13] attempts to man- GUIs for two tasks (of the four) are presented in Figure
age aphasia rehabilitation by addressing the following 1 and Figure 2. The figures show a tablet emulator with
questions: (i) What do people with aphasia want to talk the interface visible to the patients. These figures show
about? and (ii) What words and topics are selected for prac- a virtual therapist who serves as a guide to the patients
tice by aphasic patients? The authors select 100 patients throughout this therapy experience. The tasks are
prerepresenting diferent geographical locations across the sented as questions that the patient answers to progress.
UK, age brackets, genders, and exhibiting varying de- The gamified aspect of the framework is implemented
grees of capabilities on the Comprehensive Aphasia Test by including a computerized rival that aids in
demon[14]. The patients are then requested to select 100 words strating the workings of the game and also serves as a
each that they identify as important to them in their benchmark for the patients to compare their performance
daily lives. The words are then categorized by the topics against. We have implemented additional components of
and their frequency of occurrence. The authors claim uncertainty and randomness into the framework. These
that such quantitative analysis could minimize the time include elements such as a random probability generator
needed for preparing patient-specific therapy material to determine whether to award points for correctly
anand might improve the eficiency of the rehabilitation. swering a task. Including these aspects should make the</p>
      <p>Gu et al., 2020 [15] explored the possibility of inte- rehabilitation experience more engaging.
grating the behavioral and brain variables obtained from
post-stroke aphasia patients with machine learning
algorithms to categorize and predict the responsiveness to</p>
      <sec id="sec-1-1">
        <title>3.2. Tasks for rehabilitation</title>
        <sec id="sec-1-1-1">
          <title>Currently, we plan on integrating four tasks that are in</title>
          <p>volved in the traditional therapy for aphasia. These tasks
focus on improving individual aspects of language
ranging from single-word level to sentence-level complexity.
These tasks also focus on improving skills such as
retrieving a desired word, coherent speech, and fluency.
An overview of the planned tasks is provided here:
• Comprehension:</p>
          <p>This activity helps the patient at a single-word
level and strengthens the word-object mapping.
The patient is provided with two images and an
audio prompt. The patient has to select the
image corresponding to the spoken word prompt.
The GUI for this exercise is depicted in Figure
1. As a demonstration, the computerized rival
exhibits how to answer this task with several
audio prompts. As the computerized rival is
implemented to select the correct options with a preset
probability, it is also possible for the rival to
commit errors. This uncertainty aids in exhibiting to
the patients, how not to solve the task. Success
and failure of the rival are appropriately indicated
by providing video (via gifs) and audio (via
notiifcation tone) feedback. After this demonstration,
the patient is provided the audio prompt to solve
the task. Identical video and audio feedback are
provided to the patient to inform them how they
perform the task.
• Repetition:</p>
          <p>
            This activity helps improve the patient’s ability to
understand spoken words and produce coherent
speech. The patient is provided with an audio
input in this task. The patient has to then
reproduce that particular word by speaking. In this
task, the patient might answer in several ways.
The patient might repeat the name correctly. The
patient can also incorrectly repeat the given word.
It is also possible that the patient might hesitate
before answering or produce incoherent speech.
It is therefore imperative to use a speech
recognition system and corresponding evaluation metric
that handles the listed cases robustly. We plan to
record the patient’s speech and use speech
recognition systems similar to [
            <xref ref-type="bibr" rid="ref7 ref8">7, 8, 9</xref>
            ] to assess the
patient response.
• Naming:
          </p>
          <p>This task aims to improve the patient’s ability
to retrieve words from their vocabulary and
produce coherent speech. In this task, the patient
is provided a visual prompt as seen in Figure 2.
The patient has to speak the name of the object.
As the patient output modality is similar to the
previous task (audio/speech), it would be logical
to use a similar processing methodology. The
speech systems we select to use should be able to
determine if the patient’s speech corresponds to
the given prompt or not.
• Multi-word comprehension:</p>
          <p>This task helps to improve the patient’s ability
to understand the context of a given situation,
formulate their thoughts, and articulate them in
words. In this task, the patient is given an input
image similar to the one shown in Figure 3 and
is asked questions about this image. The patient
should then answer the questions based on what
they observe in this image. For instance, for the
depicted image, the patient might be asked to
answer questions such as:
(i) What do you see in this image?
(ii) How many people are in this image?
(iii) What is kept on the table?
(iv) Could you point to the {lamp, windows,
table, chair}?</p>
        </sec>
        <sec id="sec-1-1-2">
          <title>The answer provided by the patient will naturally de</title>
          <p>pend on the type of question being asked. For instance,
for (i) and (iii), the answer might be descriptive, whereas
it might primarily be numeric for (ii). Also, it is possible
that for (iv), the patient might either answer verbally,
with gestures, or point to the relevant entity in the image.
This necessitates a robust evaluation strategy for this
task.</p>
        </sec>
      </sec>
      <sec id="sec-1-2">
        <title>3.3. Adaptive dificulty adjustment</title>
        <sec id="sec-1-2-1">
          <title>In addition to the tasks discussed above, we plan to in</title>
          <p>corporate the principle of adaptive dificulty adjustment
into our framework. This idea has been explored in video
games to tune the dificulty level of the game based on the
skill and performance of the player [18, 19, 20, 21, 22, 23].
If the player finds the game too dificult, the game
dificulty is lowered. However, if the player finds the game
too easy, the dificulty level is increased. This concept
has been visualized in Figure 4. The optimum zone of
operation where the player is engaged and upgrades their
skill is in the flow zone . Anywhere other than this zone
would make the game either too dificult/too easy or not
substantially rewarding for the player.</p>
          <p>
            This principle can be utilized in aphasia rehabilitation
tasks as well [
            <xref ref-type="bibr" rid="ref4">4</xref>
            ]. If the patient finds the given task too
dificult, the patient might be frustrated. To avoid this,
the dificulty level of the task should be lowered. Once
the patient is comfortable, the dificulty level can be
gradually increased. This is done to avoid the situation in
which the patient finds the tasks too easy to solve and
loses interest. Many approaches exist to implement the
adaptive dificulty adjustment as is discussed in [ 23, 24].
Additional research will be conducted to identify which
adaptive dificulty adjustment approaches are suitable to
integrate into our framework. It also needs to be
determined, which parameters are necessary for implementing
the chosen algorithm. Quantities such as the patient’s
response time, the dificulty level of the task being solved,
and the patient’s performance/score in the tasks of
varying dificulties among others can be utilized to tune the
dynamic dificulty algorithm correspondingly. Naturally,
the choice of these parameters depends on the selection
of the algorithm.
          </p>
        </sec>
      </sec>
      <sec id="sec-1-3">
        <title>3.4. Acquisition of a new language</title>
        <p>The framework discussed in previous sections can
theoretically be used by healthy individuals who want to
learn a new language. Starting from a single-word level
complexity, the subject aiming to learn a new language
can acquire the ability to understand the situational
context with the aid of multi-modal data such as images,
audio, and videos. To this end, the framework must be
expanded to support multiple languages. This process
will involve acquiring audio data of spoken words, and a
description of visual data in the target language among
other upgrades. These modifications can be implemented
by harnessing the power of generative AI as is explored
in the works of [11].</p>
      </sec>
    </sec>
    <sec id="sec-2">
      <title>4. Discussions and Future Work</title>
      <p>In this section, we discuss the state of implementation
of the ideas discussed in this paper. Additionally, we
provide the potential research directions to be explored.
• Implementation of tasks: The discussions
concluded above provide a high-level overview of the
task description. The implementation of these
tasks is in progress. The first iteration of the
comprehension task is implemented and the
subsequent tasks will be targeted in the future.
• Evaluation criteria: For the comprehension
task, the accuracy of the patient response can
be used as the evaluation metric. The patient’s
response can be either correct or incorrect and
the accuracy can be quantified by calculating the
number of correct responses to the total number
of responses. For the subsequent tasks, we have
to identify suitable metrics. As we discussed
earlier, the patient’s response for these tasks might
also include hesitation, long pauses, and
incoherent words. We plan on categorizing the patient
responses into two categories: correct and
incorrect. For initial iterations, we will follow a broad
definition of correctness to allow patients to
familiarize themselves. The patient responses will
not be strictly evaluated and deviation from the
ground truth will be allowed. However, as the
therapy progresses, this definition of correctness
will be made stricter, and fewer errors will be
allowed. The selection of evaluation metrics will be
based on the speech recognition system we use
to implement these tasks.
• Adaptive dificulty adjustment: This aspect
will be implemented in the future. As discussed,
we have yet to identify a suitable algorithm to
integrate into our framework. Additionally, we
have to select the necessary patient parameters
that can be used to tune the dificulty level.</p>
      <p>Additional aspects can be implemented to improve
the framework in the future. As explored in [11], the
image training material for rehabilitation tasks can be
generated using a text-to-image model. This will vastly
reduce the time needed to procure the data and be a
lowcost alternative. Another possibility can be to explore
deep learning models that can generate speech from text.
This will further aid in the creation of the rehabilitation
material.</p>
    </sec>
    <sec id="sec-3">
      <title>5. Conclusion</title>
      <p>Advances in machine learning and generative artificial
intelligence can be used to create training material for
rehabilitation. Also, implementing concepts from the
domain of game design such as adaptive dificulty
adjustment algorithms into our proposed therapy framework
can make it engaging and rewarding. Finally, the scope
of the rehabilitation framework can be extended with
upgrades for additional languages. This will make the
framework useful for healthy individuals who want to
acquire a new language.</p>
    </sec>
    <sec id="sec-4">
      <title>Acknowledgments</title>
      <sec id="sec-4-1">
        <title>We acknowledge support from the Federal Ministry of Education and Research (BMBF) under grant number 13GW0481C.</title>
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