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  <front>
    <journal-meta />
    <article-meta>
      <title-group>
        <article-title>Implementing Vision Transformers in Dermatological Practice: A Web Application for Melanoma Screening</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Daniele Sirico</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Giuseppe Accardo</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Valentina Esposito</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>Data Jam srl, Centro Direzionale Isola F8</institution>
          ,
          <addr-line>Via F. Lauria, Naples, 80143</addr-line>
          ,
          <country country="IT">Italy</country>
        </aff>
      </contrib-group>
      <abstract>
        <p>In this study, we introduce a pioneering web-based application designed to enhance melanoma detection accuracy through the innovative use of a Vision Transformer (ViT) model. Leveraging the power of advanced deep learning architectures, our application processes dermatological images to identify potential melanomas with a precision previously unattainable in conventional screening methods. The development process involved finetuning the ViT model on a diverse dataset of dermatoscopic images, ensuring robustness and reliability across a wide range of images. The web application is intuitively designed, allowing for easy access and use by dermatologists and potentially by the general public for preliminary screening purposes. This research not only underscores the viability of ViT models in medical imaging but also ofers a practical tool for early melanoma detection, thereby contributing to better clinical outcomes and facilitating early treatment interventions.</p>
      </abstract>
      <kwd-group>
        <kwd>eol&gt;AI</kwd>
        <kwd>Melanoma</kwd>
        <kwd>Computer Vision</kwd>
        <kwd>Vision Trasformer</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>1. Introduction</title>
      <p>and the general public, facilitating widespread screening
and awareness.</p>
      <p>
        The early diagnosis of melanoma, a highly aggressive Such web applications can transform smartphones and
form of skin cancer, is crucial for improving patient personal computers into powerful tools for preliminary
outcomes [
        <xref ref-type="bibr" rid="ref1 ref2 ref3">1, 2, 3</xref>
        ]. When detected at an early stage, screening, empowering individuals to seek professional
melanoma can often be treated efectively, significantly advice at the earliest suspicion of melanoma. This
apreducing mortality rates [
        <xref ref-type="bibr" rid="ref1">1</xref>
        ]. However, the challenge proach to healthcare leverages the ubiquity of
internetlies in the timely and accurate identification of potential connected devices to bridge the gap between advanced
melanomas among a vast array of skin lesions, which diagnostic technologies and end-users [
        <xref ref-type="bibr" rid="ref10">10</xref>
        ]. The ease of
requires a high level of expertise and experience. In this use and accessibility of these applications are critical
faccontext, the application of artificial intelligence (AI) in tors in their adoption and efectiveness, enabling timely
medical imaging has emerged as a groundbreaking ad- intervention and potentially saving lives. In sum, the
convancement [
        <xref ref-type="bibr" rid="ref4 ref5">4, 5</xref>
        ]. AI, particularly deep learning models, vergence of AI in medical imaging and user-friendly web
has shown remarkable success in enhancing the accuracy applications marks a pivotal moment in the fight against
and eficiency of diagnostic processes in various medical melanoma, ofering new horizons for early detection and
ifelds [
        <xref ref-type="bibr" rid="ref6 ref7">6, 7</xref>
        ], including dermatology [
        <xref ref-type="bibr" rid="ref8">8</xref>
        ]. treatment.
      </p>
      <p>
        The integration of AI into medical imaging for To date, the ABCDE method is the standard
apmelanoma detection allows for the analysis of derma- proach used by medical professionals for the
diagnotological images with a level of detail and precision that sis of melanoma, emphasizing the evaluation of lesions
surpasses human capability [
        <xref ref-type="bibr" rid="ref9">9</xref>
        ]. This not only aids der- based on Asymmetry, Border irregularity, Color
variamatologists in making more informed decisions but also tion, Diameter larger than 6mm, and Evolution. Despite
has the potential to democratize access to high-quality its widespread adoption and utility in raising awareness,
diagnostic services, especially in under-resourced areas. this method’s subjective nature can lead to variability in
Furthermore, the advent of user-friendly web applica- diagnostic accuracy, potentially overlooking early-stage
tions for medical purposes represents a significant leap melanomas or prompting unnecessary biopsies of
beforward. Applications built on platforms like Streamlit of- nign lesions [
        <xref ref-type="bibr" rid="ref1">1</xref>
        ]. In response, Artificial Intelligence,
esfer an accessible interface for both medical professionals pecially through deep learning algorithms, presents a
significant advancement by providing an objective and
Ital-IA 2024: 4th National Conference on Artificial Intelligence, orga- precise analysis far surpassing the traditional methods.
nized by CINI, May 29-30, 2024, Naples, Italy By incorporating AI-driven diagnostic capabilities into a
* Corresponding author. user-friendly web application, the project aims not only
† These authors contributed equally. to enhance diagnostic precision but also to make
sophis($G.dAgc.sciarricdoo@); avl.emsapvoisviato.i@t(aDlm.Saivriicvoa).i;tg(iV.a.cEcsaprdoosi@toa)lmaviva.it ticated melanoma screening tools accessible to a wider
0000-0002-2760-9209 (D. Sirico) population. This initiative marks a crucial step forward in
© 2024 Copyright for this paper by its authors. Use permitted under Creative Commons License improving early detection rates and patient outcomes by
Attribution 4.0 International (CC BY 4.0).
bridging the gap between traditional diagnostic methods in real-world diagnostic applications.
and the potential of modern technology [
        <xref ref-type="bibr" rid="ref11 ref12">11, 12</xref>
        ]. In addition to the dataset preparation from ISIC 2019
      </p>
      <p>
        In this study, we have developed a comprehensive and ISIC 2020, the fine-tuned model was subsequently
dataset derived from the ISIC (International Skin Imaging tested on an entirely diferent dataset, MEDNODE [
        <xref ref-type="bibr" rid="ref18">18</xref>
        ],
Collaboration) Challenge datasets of 2019-2020. Utiliz- to assess its generalization capability and performance in
ing this dataset, we have fine-tuned the pre-trained Vi- real-world scenarios. This step was crucial for validating
sion Transformer (ViT) Large model provided by Google the efectiveness of our fine-tuning process and ensuring
[
        <xref ref-type="bibr" rid="ref13">13</xref>
        ], with the specific objective of classifying dermato- that the model could accurately classify melanoma across
logical images into two distinct categories: "Melanoma" diverse datasets. The MEDNODE dataset, distinct in its
and "Non-Melanoma". The model has been meticulously composition and image characteristics, provided a
chaladapted to the unique characteristics of dermatological lenging environment to evaluate the model’s robustness
imagery. While the ViT model inherently possesses a and adaptability. This further testing underscores the
broad capability for image recognition owing to its ex- model’s potential for application in a wide range of
clinitensive initial training on diverse data, our fine-tuning cal settings, demonstrating its ability to maintain high
process has significantly enhanced its accuracy and sen- levels of accuracy and sensitivity in detecting melanoma,
sitivity to the specific features of skin lesion images. This even when confronted with data significantly diferent
targeted refinement improves the model’s diagnostic pre- from that on which it was trained. This cross-dataset
cision, making it a highly efective tool for distinguishing validation is a critical aspect of our research, confirming
between melanoma and non-melanoma cases. By lever- the model’s utility as a reliable tool in the early detection
aging the cutting-edge ViT architecture and tailoring it of melanoma, potentially revolutionizing dermatological
to the nuances of dermatological conditions, we aim to diagnostics.
advance the field of medical imaging and ofer a more
accurate, AI-driven approach to melanoma detection.
      </p>
    </sec>
    <sec id="sec-2">
      <title>3. Fine Tuning and Validation</title>
    </sec>
    <sec id="sec-3">
      <title>2. Dataset Preparation</title>
      <sec id="sec-3-1">
        <title>3.1. Fine Tuning</title>
        <p>
          In this work, we have constructed a dataset starting The concept of transfer learning, applied to the context
from the data of the ISIC Challenges of 2019 [
          <xref ref-type="bibr" rid="ref14 ref15 ref16">14, 15, 16</xref>
          ] of melanoma detection using Google’s pre-trained Vision
and 2020 [
          <xref ref-type="bibr" rid="ref17">17</xref>
          ], with which we fine-tuned Google’s pre- Transformer (ViT) Large model, leverages a model
develtrained Vision Transformer (ViT) Large model, aiming oped for general vision tasks and adapts it to the specific
to distinguish between two classes: "Melanoma" and "No challenge of identifying melanoma in dermatological
imMelanoma". The model has been specifically adapted to ages. This approach benefits from the original model’s
the characteristics of dermatological images. Although learning capabilities, significantly reducing the time and
the network already possesses a broad capacity for recog- resources needed for training from scratch. Thanks to its
nition due to its prior training, fine-tuning allows us to prior training, the model can be optimized to recognize
refine its precision and sensitivity to the peculiarities the specific features of melanoma with greater eficiency.
of skin lesions, thereby improving the accuracy of diag- During the fine-tuning process, the already pre-trained
noses. ViT Large model from Google is further optimized for
        </p>
        <p>For the dataset preparation, with the objective of melanoma detection. In this phase, the model is
specifiachieving balanced classes between Melanoma and No cally adapted to the characteristics of dermatological
imMelanoma, images were extracted from ISIC 2019 and ages. Although the network already has a broad
recogniISIC 2020. The resulting dataset comprises 8,223 training tion capability thanks to its previous training, fine-tuning
images and 1,450 test images, witnessing a significant allows for the refinement of its precision and
sensitivincrease in the sample size, especially in the number of ity to the peculiarities of skin lesions, thus enhancing
images within the Melanoma class of interest (3,890 No diagnostic accuracy.</p>
        <p>Melanoma, 4,333 Melanoma). This dataset was synthe- The development environment utilized for training
sized from images sourced from ISIC 2019 and ISIC 2020. the model features the following specifications in AWS
Specifically, the “Melanoma” class benefited from con- Environment: p3.2xlarge, Intel(R) Xeon(R) CPU E5-2686
tributions from both datasets, while the “No-Melanoma” v4 @ 2.30GHz, 64GB RAM, Graphics Card: Tesla
V100class was formed using images exclusively from ISIC 2019. SXM2 with 16GB of VRAM.</p>
        <p>This balanced approach ensures a more equitable distri- For the inference phase, no specific dedicated
hardbution of classes, enhancing the model’s ability to learn ware with GPU is required. This flexibility in hardware
and accurately diferentiate between Melanoma and No requirements for inference ensures that the fine-tuned
Melanoma, which is crucial for the model’s performance model can be deployed in a wide range of environments,
making it accessible for clinical use without the need for
high-performance computing resources.</p>
      </sec>
      <sec id="sec-3-2">
        <title>3.2. Validation on ISIC Test Set</title>
        <p>The results obtained from the model on the test set, as
detailed in Table 1, underscore its adeptness in
distinguishing between melanoma and non-melanoma lesions,
showcasing substantial precision, recall, and F1-score Figure 1: Diagnostic Performance of the Vision Transformer
metrics across both categories. For the "No Melanoma" Model for Melanoma Detection on ISIC test set. On the left,
class, precision was marked at 0.86, with a recall of 0.83 the confusion matrix illustrates the model’s accuracy in
clasand an F1-score of 0.85, across a support of 677 cases. sifying 1: ’Melanoma’ and 0: ’No Melanoma’ cases, with the
This high level of accuracy in identifying non-melanoma number of true positives, true negatives, false positives, and
instances indicates a strong balance between the preci- fCahlsaerancetgearitsitviecs).cOurnvet.he right, the ROC (Receiver Operating
sion and recall, reflecting the model’s eficiency in
minimizing false positives while efectively recognizing true
negatives.</p>
        <p>Conversely, the "Melanoma" class demonstrated pre- ize melanoma screening and diagnosis through the
incision and recall scores of 0.86 and 0.88, respectively, tegration of cutting-edge AI technologies into clinical
achieving an F1-score of 0.87 over 773 instances. These practices, thereby enhancing diagnostic accuracy and
metrics highlight the model’s capability in reliably detect- facilitating improved patient care.
ing melanoma lesions, with the elevated recall indicating
a particular strength in reducing false negatives—crucial 3.3. Validation on MEDNODE Dataset
for melanoma screening where the cost of missing a
positive diagnosis is exceedingly high. The model’s performance on the MEDNODE dataset, as</p>
        <p>The consistency in precision across both classes, paired detailed in Table 2, reflects its diagnostic precision in
with the balanced F1-scores, attests to the model’s robust- distinguishing between melanoma and non-melanoma
ness, suggesting its potential as a dependable tool in the cases. With a precision of 0.83 and a recall of 0.98 for "No
diagnostic toolkit. Such performance, detailed in Table 1, Melanoma," the model demonstrates a high capability in
afirms the advanced AI models, like the Vision Trans- correctly identifying non-melanoma cases, as evidenced
former’s, significant role in dermatological diagnostics. by an F1-score of 0.90 across 100 instances. This high</p>
        <p>Further insight into the model’s performance is pro- recall rate is crucial, indicating the model’s strength in
vided by Figure 1, which depicts the confusion matrix minimizing the risk of false negatives in non-melanoma
and the ROC curve for the model’s predictions. The con- diagnoses, which is vital for avoiding unnecessary further
fusion matrix visually illustrates the model’s accuracy testing and anxiety for patients.
in classifying the test cases, ofering a clear depiction Conversely, for the "Melanoma" category, the
preciof the true positive and negative rates, alongside the in- sion stands at an impressive 0.96, showing the model’s
stances of false positives and negatives. The ROC curve, reliability in its melanoma predictions. However, the
reaccompanying this matrix, further elucidates the model’s call of 0.71 highlights a potential area for improvement
diagnostic ability across diferent thresholds, showcas- in capturing all true melanoma cases, with an F1-score of
ing its exceptional capability to balance sensitivity and 0.82 across 70 instances reflecting the balance between
specificity efectively. Together, Table 1 and Figure 1 precision and the need to improve recall.
ofer a comprehensive overview of the model’s diagnos- Figure 2 provides further insight into these results
tic performance, highlighting its potential to revolution- through a visual representation. The left side of the
figure features the confusion matrix, illustrating the model’s
taining high diagnostic accuracy, the model paves the
way for broader clinical adoption, ofering a promising
tool for early melanoma detection and thereby improving
patient outcomes through timely and accurate diagnoses.</p>
      </sec>
    </sec>
    <sec id="sec-4">
      <title>4. Streamlit WebApp</title>
    </sec>
    <sec id="sec-5">
      <title>5. Conclusion</title>
      <p>visualizes the diagnostic results, including the probabil- AI-driven diagnostics accessible to a broad audience.
ity of melanoma presence. This section exemplifies the In essence, this work illustrates the synergy between
critical role of data visualization in making complex AI cutting-edge AI technology and user-centric application
analyses accessible and understandable to users, facilitat- design in addressing the critical healthcare challenge of
ing an informed interpretation of the results. early melanoma detection. By marrying the technical</p>
      <p>The emphasis on data visualization and ease of use prowess of Vision Transformers with the accessibility
within the Streamlit application not only democratizes and clarity provided by Streamlit, this initiative paves
access to advanced melanoma detection tools but also sig- the way for future advancements in the field of
medinificantly enhances the user experience. By translating cal imaging and diagnosis. It stands as a testament to
sophisticated AI diagnostics into intuitive visual outputs, the potential of AI to not only revolutionize
diagnosthe application bridges the gap between complex medical tic processes but also to empower individuals with the
data and actionable insights, making it an invaluable tool tools and knowledge necessary for early detection and
in the early detection of melanoma. intervention, ultimately contributing to better healthcare
outcomes and the broader goal of reducing
melanomarelated mortality.</p>
      <p>In conclusion, this article has presented a comprehensive
exploration of an innovative web application developed
for the early detection of melanoma, leveraging the
advanced capabilities of Vision Transformers (ViTs) and
the intuitive platform of Streamlit. The initial stages
of this work involved the meticulous construction of
a dataset from the ISIC Challenges of 2019 and 2020,
followed by the fine-tuning of a pre-trained ViT Large
model from Google, with the dual objectives of
distinguishing between "Melanoma" and "No Melanoma" cases
and adapting the model to the unique characteristics of
dermatological images. This process was underscored
by the strategic preparation of the dataset to ensure
balanced classes, thereby enhancing the model’s learning
and predictive accuracy.</p>
      <p>Subsequent testing on the distinct MEDNODE dataset
confirmed the model’s robustness and adaptability,
demonstrating significant diagnostic precision across
varying conditions. The application of transfer learning
techniques further exemplified the utility of leveraging
existing AI models for specialized tasks, reducing both
the time and resources required for model development
from scratch. The deployment environment,
characterized by high-performance computing resources,
facilitated the model’s training and validation phases, while
the streamlined requirements for the inference phase
underscored the model’s practical applicability in diverse
clinical settings.</p>
      <p>The Streamlit-based web application represents a
significant stride towards democratizing access to advanced
diagnostic tools. By ofering an intuitive interface for
uploading and analyzing dermatological images, coupled
with real-time presentation of diagnostic results, the
application emphasizes the critical role of data visualization
in enhancing user engagement and understanding. Each
segment of the application, from providing background
on melanoma detection to visualizing AI-generated
predictions, is designed to make the complex process of</p>
    </sec>
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