=Paper=
{{Paper
|id=Vol-3805/ICBO-2022_paper_6701
|storemode=property
|title=The Ontology of Adverse Events in 2022
|pdfUrl=https://ceur-ws.org/Vol-3805/ICBO-2022_paper_6701.pdf
|volume=Vol-3805
|authors=Qiuyue Yang,Jun Su,Xue Zhang,Yongqun He, Jiangan Xie
|dblpUrl=https://dblp.org/rec/conf/icbo/YangSZHX22
}}
==The Ontology of Adverse Events in 2022==
<pdf width="1500px">https://ceur-ws.org/Vol-3805/ICBO-2022_paper_6701.pdf</pdf>
<pre>
                         The Ontology of Adverse Events in 2022
                         Qiuyue Yang1, Jun Sun1, Xue Zhang1, Yongqun He2, and Jiangan Xie2
                         1
                                School of Bioinformatics, Chongqing University of Posts and Telecommunications, Chongqing, China
                         2
                                University of Michigan Medical School, Ann Arbor, MI, USA.


                                              Abstract
                                              The Ontology of Adverse Events (OAE) was launched in 2014 to define, standardize and
                                              integrate various adverse events (AEs) arising subsequent to medical interventions (such as
                                              vaccination, drug administration, and surgery). The AE term system of OAE has grown
                                              steadily since OAE has successfully been applied in many adverse event studies. Here, we
                                              present recent major extensions of the OAE for patient anatomic regions and clinical
                                              outcomes (e.g., symptoms, signs, and abnormal process). Up to now, OAE has 10,829 terms
                                              with unique identifiers, including 10,589 classes, 120 object properties, 3 datatype properties,
                                              113 annotation properties, and 4 instances. Compared to the 3,088 ontology terms included in
                                              the last OAE publication in 2014, 7,741 new terms (over twofold more terms) have been
                                              added to OAE, which representing significant progress of the ontology. We have also
                                              reviewed recent studies using OAE for representing and classifying the adverse events
                                              associated with specific medical interventions (e.g., drug administration and vaccination). The
                                              OAE ontological framework provides a platform for systematic representation and analysis of
                                              adverse events and of the factors (e.g., vaccination route and age) important for determining
                                              their clinical outcomes.


                                              Keywords
                                              Ontology, adverse event, medical intervention, OAE, Ontology of Adverse Events


                     ICBO 2022, September 25-28, 2022, Ann Arbor, MI, USA
                     EMAIL: xjahardy@hotmail.com (A. 1); yongqunh@med.umich.edu (A. 2)
                     ORCID: 0000-0003-0958-3364 (A. 1); 0000-0001-9189-9661 (A. 2)
                                         2022 Copyright for this paper by its authors. Use permitted under Creative
                                       Commons License Attribution 4.0 International (CC BY 4.0).

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