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  <front>
    <journal-meta />
    <article-meta>
      <title-group>
        <article-title>An Ontological Representation of Money with a View Toward Economic Determinants of Health</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Matt Diller</string-name>
          <email>diller17@ufl.edu</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>William R. Hogan</string-name>
          <email>hoganwr@ufl.edu</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>Department of Health Outcomes and Biomedical Informatics, University of Florida</institution>
          ,
          <addr-line>Gainesville, FL</addr-line>
          ,
          <country country="US">USA</country>
        </aff>
      </contrib-group>
      <abstract>
        <p>Money plays a large role in people's access to healthcare and to health-related resources, such as food, education, and housing. Because of this and its association with mortality and various health outcomes, identifying risks due to financial instability are of key importance to researchers and clinicians. While biomedical ontologies are often used to build structured datasets to enable sharing and integration of health-related data, the semantic representation of money and income, as well as other economic determinants of health (EDH), are limited. As such, identifying and filling gaps in existing ontological representations of income are needed. In this paper, we describe our approach to representing a key aspect of income and other EDHmoney. We reviewed existing representations of money and financial transactions in publicly available biomedical ontologies for potential reuse and identified their strengths and weaknesses. Since we did not find any classes that sufficiently represent money or financial transactions for general use, we extended the Ontology of Medically Related Social Entities (OMRSE) by creating 7 new classes and importing four classes to represent money, financial obligations, four of the essential types of processes money is used in, and currency. We explain why our approach to representing 'money' has the advantage of being broadly applicable to both modern and historic forms of money that exist as bank accounts, currency, or consist of objects that have a secondary use as money (e.g., cigarettes).</p>
      </abstract>
      <kwd-group>
        <kwd>1 money</kwd>
        <kwd>social-determinants of health</kwd>
        <kwd>economic-determinants of health</kwd>
        <kwd>economics</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>1. Introduction</title>
      <p>
        The relationship between money and health is
complex. In countries without free or universal
healthcare, like the United States, people need
money to purchase healthcare services and
medication. The amount of money they have
therefore can affect greatly their ability to obtain
necessary care. Additionally, having a higher
income is associated with various other factors
such as better schools, nutrition, recreational
resources, and housing, all of which also have
documented associations with health outcomes
(
        <xref ref-type="bibr" rid="ref1">1</xref>
        ). Indeed, in regions with noticeable disparities
in income, studies have shown a link between
income distribution and rates of mortality (
        <xref ref-type="bibr" rid="ref2 ref3">2,3</xref>
        ).
      </p>
      <sec id="sec-1-1">
        <title>The importance of income in healthcare has</title>
        <p>
          motivated some to develop tools that assess
patient risk using social and economic
determinants of health, such as the Protocol for
Responding to and Assessing Patient Assets,
Risks, and Experiences (PRAPARE) Screening
Tool (
          <xref ref-type="bibr" rid="ref4">4</xref>
          ). The PRAPARE Screening Tool is a
standardized assessment of patient risk that
includes income- and money-related questions,
like “What is your family’s total combined
income?” and “In the past year, have you or any
family members you live with been unable to get
[Food/Clothing/Utilities/Healthcare/Child
Care/Phone/etc.] when it was really needed?".
        </p>
        <p>
          Therefore, if biomedical ontologies are to be
used to integrate health data with social and
economic data for researchers and clinicians, they
will need to be equipped with representations of
income, and with it, money. However,
representing the latter is not an easy task. Despite
coming in various forms, such as cash or coins,
money in the modern world is widely considered
to be a social construct (
          <xref ref-type="bibr" rid="ref5 ref6 ref7 ref8">5–8</xref>
          ). In fact, according to
modern theories, money is a type of debt (
          <xref ref-type="bibr" rid="ref10 ref9">9,10</xref>
          ) in
the sense that it represents the good faith of
another party to settle its debt. For example, a
banknote that has been issued by the United States
(US) Federal Reserve represents an obligation (an
IOU, so to speak) the US government has to
whoever possesses the banknote to recognize it as
a means of paying for taxes, fines, or US
securities. For the person who possesses the
banknote, that piece of money will represent a
claim that they have against the US government.
Thus, each debt necessarily has an associated
debtor and creditor. Indeed, such theories underly
much of how modern monetary policy is
conceptualized and conducted, and have been
adopted by major financial institutions around the
world, such as the US Federal Reserve and
International Monetary Fund (
          <xref ref-type="bibr" rid="ref11 ref12">11,12</xref>
          ). As such,
these institutions widely consider highly liquid
assets like checking deposits and traveler’s
checks, in addition to currency, to be money. Due
to technological innovation over time, they have
also come to categorize slightly less liquid assets
that can easily be converted into currency or
moved to a checking account, such as a savings
account and small time deposits, as money.
Lastly, money in modern economics and finance
is typically viewed as being created by both
governments and commercial banks since the
former can create and issue currency and the latter
can issue loans that are then deposited into
checking accounts.
        </p>
        <p>
          Although each of these forms of money differ
in substance (e.g., currency is something that is
material, while checking deposit accounts are
immaterial) and in how they’re created, they are
traditionally considered to have four “functions”
(
          <xref ref-type="bibr" rid="ref13">13</xref>
          ). We note that the term “function of money”
is an economic—not an ontological—term of art.
From here on, when we talk about “functions” of
money, we are borrowing the economic usage of
the term until we develop an account of money
and our ontological theory of these “functions”.
We note for now that these “functions” of money
are not at all functions as defined by upper-level
ontologies such as Basic Formal Ontology. The
first function of money is as a medium of
exchange, which is what allows money to be
exchanged for goods and services. Its second
function is the measure of value function, which
enables money to serve as a standard unit of
measure when assessing a numeric value of a
good or service. Third, money functions as a
standard of deferred payment, which means that it
is widely used to value and settle debts. The fourth
and final function is the store of value function
that provides a high level of assurance that money
will retain its value over time after being stored
for retrieval later.
        </p>
        <p>
          With this knowledge in mind, we reviewed
past attempts at representations of money in
publicly available Web Ontology Language
(OWL 2) ontologies, with the intention of reusing
classes where possible and creating our own
classes where needed in the Ontology of
Medically Related Social Entities (OMRSE) (
          <xref ref-type="bibr" rid="ref14">14</xref>
          ).
OMRSE is an appropriate home for these terms
given that money and its functions are
quintessential social entities and are highly
medically relevant as a social determinant of
health. Through the efforts described in this paper,
anyone can reuse the classes that we developed to
assert that any type of material entity is money or
holds value (e.g., gold).
        </p>
      </sec>
    </sec>
    <sec id="sec-2">
      <title>2. Methods</title>
      <sec id="sec-2-1">
        <title>For this project, we extended OMRSE to</title>
        <p>
          include money-related classes that can be used to
richly and expressively represent various EDH.
OMRSE (
          <xref ref-type="bibr" rid="ref14">14</xref>
          ) is an open source, mid-level domain
ontology for representing social entities that are
relevant to health. It is developed and maintained
using the OBO Ontology Development Kit
(ODK) (
          <xref ref-type="bibr" rid="ref15">15</xref>
          ) and can be found at
https://github.com/ufbmi/OMRSE. OMRSE is an
OBO Foundry library ontology (
          <xref ref-type="bibr" rid="ref16">16</xref>
          ), and it
imports the Basic Formal Ontology (BFO) (
          <xref ref-type="bibr" rid="ref17">17</xref>
          )
for its top level to enable interoperability with
other BFO-aligned ontologies.
        </p>
        <p>
          Our first steps were to identify and review any
and all classes in existing OBO-aligned
ontologies that are used to represent money and
financial entities relevant to EDH. To accomplish
this, we performed a search of three online
databases for viewing and downloading the
content of ontologies: the OBO Foundry’s
Ontobee (
          <xref ref-type="bibr" rid="ref18">18</xref>
          ), the European Bioinformatics
Institute’s (EMBL-EBI) Ontology Lookup
Service (OLS) (
          <xref ref-type="bibr" rid="ref19">19</xref>
          ), and the National Center for
Biotechnology Information’s (NCBI) BioPortal
(
          <xref ref-type="bibr" rid="ref20">20</xref>
          ). For each database, we manually performed a
keyword search for ontology classes using the
following search terms: “money”, “finance”,
“financial”, and “transaction.”
referent of the OMRSE class is distinct from the
referent of a related, existing class (possibly with
the same label), typically being more general (i.e.,
being more inclusive of a range of types of
entities).
        </p>
        <p>
          We reviewed any classes that were identified
through each search if they had English label and
definition annotations. In addition, we relied on
our knowledge of other ontologies to identify
further classes for reuse. In reviewing each
identified class, we looked at the quality of its
definition before deciding to import it. To assess
the quality of each definition, we took into
account whether they included the four traditional
functions of money: medium of exchange,
measure of value, standard of deferred payment,
and store of value (
          <xref ref-type="bibr" rid="ref13">13</xref>
          ). We also looked at whether
a definition was broad enough to include ancient
and modern forms of commodity money,
representation money, and fiat money. Our
motivations for assessing the definitions along
these criteria were to ensure that they are domain
independent and accurate enough to capture the
characteristics of money that make it such a vital
social entity for everyday life. Any class that was
determined to be of sufficient quality was
imported using the ODK’s custom imports
template workflow, which uses a ROBOT filter
based approach to import classes (
          <xref ref-type="bibr" rid="ref21 ref22">21,22</xref>
          ). Terms
we did not find equivalent classes for in existing
ontologies were defined according to the
principles of ontological realism (
          <xref ref-type="bibr" rid="ref23">23</xref>
          ) and added
to OMRSE using the Protégé ontology editing
tool (
          <xref ref-type="bibr" rid="ref24">24</xref>
          ).
        </p>
      </sec>
    </sec>
    <sec id="sec-3">
      <title>3. Results</title>
      <sec id="sec-3-1">
        <title>Our review of existing representations of</title>
        <p>
          money in ontologies indexed in Ontobee,
BioPortal, and OLS returned several potential
candidates for reuse, however none of them met
our quality criteria. We did, however, end up
reusing three classes from the Document Acts
Ontology (d-acts)—‘social act’, ‘claimant role’
and ‘duty holder role’—in our representation of
money and debt obligations. We also imported
‘predicted data item’ from the Ontology of
Biomedical Investigations (OBI) (
          <xref ref-type="bibr" rid="ref25">25</xref>
          ). Because
money and social entities related to it are within
the scope of OMRSE, if we could not reuse an
existing class, we created a new class in OMRSE
with a distinct definition. In nearly every case, due
to various deficiencies of existing classes, the
        </p>
      </sec>
      <sec id="sec-3-2">
        <title>In total, we created 7 new classes in OMRSE</title>
        <p>and imported four classes from OBO ontologies
to represent money, the functions of money, the
processes through which those functions are
utilized, debt obligations, and currency. We also
created textual definitions for each of the 7 new
OMRSE classes.</p>
      </sec>
    </sec>
    <sec id="sec-4">
      <title>3.1. Review of Current</title>
    </sec>
    <sec id="sec-5">
      <title>Representations of Money OWL</title>
      <p>Through our searches of Ontobee, BioPortal,
and OLS, we identified several potential terms for
reuse. After removing duplicates and classes with
no textual definition, we were left with two
classes representing ‘money’ and two classes
representing ‘financial transaction’. We also
discovered two classes representing ‘payment’
and one class representing ‘selling’.</p>
      <p>
        The first class that represents ‘money’ that we
identified comes from the Gender, Sex, and
Sexual Orientation (GSSO) Ontology (
        <xref ref-type="bibr" rid="ref26">26</xref>
        ). This
ontology was designed to support the annotation
of data related to various social groups and
identities that relate to gender, sex, and sexual
orientation and uses BFO for its top-level
hierarchy. GSSO defines ‘money’ as “Any item or
verifiable record that is generally accepted as
payment for goods and services and repayment of
debts, such as taxes, in a particular country or
socio-economic context.” This definition captures
many of the essential characteristics of money (in
fact, it is the most comprehensive definition we
found), however it fails to define money as a debt
itself and in so doing fails to capture the
associated claim that the owner of that money
possesses. The definition also leaves out any
mention of money being a standard of value or a
store of value. GSSO also contains a class
representing ‘financial transaction’, which it
defines as “An agreement, or communication,
carried out between a buyer and a seller to
exchange an asset for payment.” Some financial
transactions, such as payments of debt, however,
do not involve the exchange of an asset in return
for a sum of money paid. Another example is the
provision of services as opposed to an asset. We
therefore also deemed this definition as too
narrow for our needs.
payments involved in medical care. As such, we
did not import it due to its very narrow scope.
      </p>
      <p>
        The second class we identified that represents
‘money’ comes from the National Cancer Institute
Thesaurus (NCIt), which was originally
developed by the National Cancer Institute to
support the sharing and interoperability of data
between each of its subdivisions and is now
widely used by public and private organizations
around the world (
        <xref ref-type="bibr" rid="ref27">27</xref>
        ). It contains a class labeled
‘Money’ (C88415) that is defined as “The official
currency issued by a government or national
bank.” We deemed this definition to be too narrow
to justify reusing it since it excludes forms of
money not issued by a government entity that may
be used by groups of people today, such as by
various indigenous tribes throughout the world, or
forms of money that predate modern governments
and state entities, or even checking accounts. In
fact, the class definition more closely resembles
definitions in modern economics for ‘currency’
(
        <xref ref-type="bibr" rid="ref12 ref6 ref7 ref8">6–8,12</xref>
        ), and indeed ‘Currency’ is listed as an
exact synonym. NCIt also contains a class for
‘Payment’ (C25371), which it circularly defines
as “A sum of money paid.” Unfortunately, this
definition is uninformative as to what the class
represents, so we did not reuse it.
      </p>
      <p>
        Our search also led us to identify a class in the
Informed Consent Ontology (ICO), labeled ‘act of
selling’ (ICO:0000423). ICO is an ontology
aligned with BFO that describes itself as an
ontology for representing informed consent and
related processes in medicine (
        <xref ref-type="bibr" rid="ref28">28</xref>
        ). Its definition
of ‘act of selling’ is defined as “A planned process
in which goods or services are exchanged for
money.” However, goods and services are not the
only entities that one can sell—one can also sell
various types of financial assets or liabilities that
likely cannot be accurately described as being
either a good or a service (e.g., debts are often sold
to debt collectors). As such, we did not end up
reusing this class.
      </p>
      <p>
        Lastly, we found a class labeled ‘monetary
payment’ in the Behaviour Change Intervention
Ontology (BCIO), which aims to model
interventions involving changes to human
behavior and the various methods used to evaluate
them (
        <xref ref-type="bibr" rid="ref29">29</xref>
        ). This class (BCIO:010131) is defined as
“A payment of person source that is money,
vouchers or valued objects given to the source for
delivering the intervention.” It is obvious from
this definition that this class refers to only those
      </p>
    </sec>
    <sec id="sec-6">
      <title>3.2. Development of Classes for</title>
    </sec>
    <sec id="sec-7">
      <title>Debt and Money</title>
      <p>
        When we originally set out to define both
‘debt’ and ‘money’, we immediately ruled out
‘occurrent’ (BFO:0000003) as a possible parent
class since neither debt nor money are things that
can be divided into temporal parts. To distinguish
money from other types of debt, our first
inclination was to explicitly represent the four
functions of money as BFO roles. In BFO, roles
are defined as “A realizable entity that (
        <xref ref-type="bibr" rid="ref1">1</xref>
        ) exists
because the bearer is in some special physical,
social, or institutional set of circumstances in
which the bearer does not have to be, and (
        <xref ref-type="bibr" rid="ref2">2</xref>
        ) is
not such that, if this realizable entity ceases to
exist, then the physical make-up of the bearer is
thereby changed” (
        <xref ref-type="bibr" rid="ref17">17</xref>
        ). As such, it inherits from
its parent class—‘realizable entity’
(BFO:0000017)—the characteristic of inhering in
independent continuants that are not spatial
regions. Since we would want to assert that money
is any debt that is the bearer of all four roles,
simultaneously, this limits the options in BFO for
a parent class for both ‘debt’ and ‘money’ to the
following: ‘continuant fiat boundary’
(BFO:0000140), ‘site’ (BFO:0000029),
‘immaterial entity’ (BFO:0000141), and ‘material
entity’ (BFO:0000040). We immediately ruled
out ‘continuant fiat boundary’ and ‘site’ as
possible parent classes, as debt and money are
obviously neither boundaries nor sites. From this,
we also ruled out ‘immaterial entity’ as a parent
class since it is defined as “An independent
continuant that contains no material entities as
parts. Immaterial entities divide into two major
subgroups: (
        <xref ref-type="bibr" rid="ref1">1</xref>
        ) boundaries and sites, and (
        <xref ref-type="bibr" rid="ref2">2</xref>
        )
spatial regions” (
        <xref ref-type="bibr" rid="ref17">17</xref>
        ). Additionally, because
money, and therefore debts, can exist as digital
records in a commercial bank’s databases (i.e.,
checking deposit accounts) without those
databases or other hardware that are used to store
records and process transactions ever being usable
as money, we ruled out ‘material entity’ as a
possible parent class.
      </p>
      <p>
        Indeed, it is this fact that debts and money can
exist both in multiple material and digital forms
that led us to further rule out ‘specifically
dependent continuant’ (BFO:0000020) and
identify ‘generically dependent continuant’
(BFO:0000031) as a possible parent class. Our
decision to eliminate ‘specifically dependent
continuant’ (SDC), which is defined as “A
continuant entity that depends on precisely one
independent continuant for its existence” (
        <xref ref-type="bibr" rid="ref17">17</xref>
        ),
stems from the fact that the money in one’s
checking account can inhere in one database today
and then after a bank acquisition be moved to a
different database tomorrow. This left us with
‘generically dependent continuant’ (GDC), which
BFO defines as “A continuant that is dependent
on one or other independent continuants and can
migrate from one bearer to another through a
process of copying” (
        <xref ref-type="bibr" rid="ref17">17</xref>
        ). This aspect of being
migratable made this class a promising candidate
since multiple records of a particular debt or
multiple copies of a particular denomination of
currency can exist at once. BFO also describes
GDCs as being concretized in an SDC that itself
inheres in an independent continuant. An example
of this is the instance of a Coca-Cola logo—itself
a copyable pattern that can exist in multiple
bearers, and thus is a GDC—being concretized as
the patterns of ink—an SDC, or more specifically
a quality (BFO:0000019)—on a plastic bottle.
      </p>
      <p>However, there is more to be said about debts
and money than just being copyable, although we
note here that there are socially built-in
constraints to restrict—and in the case of paper
and coin-based currency, prohibit—creating
unauthorized copies. For one, all debts involve at
least one party to whom the debt is owed (i.e., the
creditor) and at least one party that owes the debt
(i.e., the debtor). Following from past work in the
Document Acts Ontology (d-acts), we propose
that a creditor can be represented as a human or
organization that bears a claimant role
(IAO:210013), which is defined as “A deontic
role that inheres in an agent A, that mutually
depends on the existence of a duty holder role
borne by agent B, and that specifies B doing or
abstaining from C, or providing or surrendering C
to A.” Similarly, we can represent a debtor as a
human or organization that is the bearer of a duty
holder role (IAO:210016), which d-acts defines as
“A deontic role that inheres in an agent A, that
mutually depends on the existence of a claimant
role borne by agent B, and that specifies A doing
or abstaining from some action C, or providing or
surrendering C to B.” Additionally, money is a
type of debt that can be used as a medium of
exchange, a standard of deferred payment, a store
of value, and a standard of value. With this in
mind, we define ‘debt obligation’ and ‘money’ as
follows:
debt obligation =def. A directive information
entity that prescribes that something will be
transferred from some human or organization
that is the bearer of a duty holder role to
another human or organization that is the
bearer of a claimant role.
money =def. A debt obligation between two
parties that has part a scalar value
specification and whose concretizations
indicate that their bearers can be used in a
financial transaction or payment of debt, or as
a measure of the value of some entity in a
financial valuation process or prospective
financial valuation process.</p>
      <p>We identified ‘directive information entity’
(IAO:0000033), which IAO defines as “An
information content entity whose concretizations
indicate to their bearer how to realize them in a
process,” as the best parent class for ‘debt
obligation’. We justify this by nothing that
concretizations of debt obligations, including
money, indicate how the associated duty holder
and claimant roles can be realized—a simple
paper record of a debt will contain concretizations
that explain how the debt is to be paid, a piece of
currency concretizes an obligation the issuing
government has to recognize it as payment for
taxes or treasury bonds, and the online record of
your checking deposit account as its appears on a
computer screen concretizes an obligation a
commercial bank has to provide you with funds
upon request. For money, we state in the
definition that its concretizations indicate that its
bearer can be used in a financial transaction (i.e.,
as a medium of exchange) or a payment of debt
(i.e., as a standard of deferred payment), or in a
financial valuation process (i.e., as a standard of
value) or prospective valuation process (i.e., as a
store of value) as a measure of the value of some
entity, such as another debt, a material object, or
a service. These concretizations are instantiated as
qualities, such as the patterns of ink that are
printed on a US banknote or the shape, color, and
size of material entities that are used as
commodities (e.g., cigarettes in prisoners-of-war
camps (30)). Lastly, we define ‘money’ as having
a scalar value specification as a part, which the
Ontology for Biomedical Investigations (OBI)
defines as “A value specification that consists of
two parts: a numeral and a unit label.” Although it
is easy to see how currency can have a scalar value
specification, in that the number printed on the
coin or banknote represents that value
specification, it is less obvious for commodities
that are used as money, such as cigarettes. For this
type of money, we believe that the scalar value
specification will take a value of “1” to indicate
that that instance of money represents one unit, or
it will derive this value from other commodities of
the same type (e.g., a hand-rolled cigarette might
be worth two Red Cross cigarettes, and thus it will
have a scalar value specification equal to two Red
Cross cigarettes). We additionally define
‘financial transaction’, ‘payment of debt’,
‘financial valuation process’, and ‘prospective
financial valuation process’ as follows:
•
•
•
•
financial transaction =def. A planned process
whereby one participant partly or completely
fulfills an obligation to another participant by
transferring ownership of some other debt
obligation, which is typically money.
payment of debt =def. A planned process
whereby ownership of some entity of value is
transferred by one participant to another to
fulfill some obligation, on their behalf, after
some service is performed or the ownership of
some entity is exchanged.
financial valuation process =def. A planned
process that has as specified output some
scalar measurement datum that is about an
entity—such as a material good or a service—
and is measured in terms of the quantity of
some other material entity.
prospective financial valuation process =def.
A planned process that has as specified output
some predicted value that is about an entity—
such as a material good or a service—and is
measured in terms of the quantity of some
material entity at some point in the future.</p>
      <p>For ‘financial transaction’, we do not say in
the definition that some quantity of money is
transferred from one participant to the other to
allow for other types of things to be used in place
of money. For example, credit cards are not
considered money because the resulting credits
are debt that the owner of the card owes to a credit
card company. Similarly, payments of debt can be
settled and things can be valued with items other
than money, which is why we did not specify in
our definitions of ‘payment of debt’, ‘financial
valuation process’, and ‘prospective financial
valuation process’ that only money may be used.
In addition, although ‘financial valuation process’
and ‘prospective financial valuation process’ are
very similar processes—indeed, one might be led
to think that the latter could be a subclass of the
former—it is important to note that the data items
that are output from them are a bit different. For
‘financial valuation process’, the data item that is
referenced in the definition is the Information
Artifact Ontology’s (IAO) ‘scalar measurement
datum’ (IAO:0000032) (31), whereas
‘prospective financial valuation process’
references OBI’s ‘predicted value’
(OBI:0001934).
3.3.</p>
    </sec>
    <sec id="sec-8">
      <title>Defining Currency</title>
      <p>
        Lastly, we define ‘currency’ since it is one of
the most common forms of money in the modern
era. Currency is commonly known as anything
that has been declared to be an acceptable means
of settling debts, including taxes, and an
acceptable medium of exchange by a government
entity (
        <xref ref-type="bibr" rid="ref12 ref6 ref7 ref8">6–8,12</xref>
        ). Currencies are physically made
and issued by government or government
sanctioned institutions, such as the United States
Federal Reserve (
        <xref ref-type="bibr" rid="ref11">11</xref>
        ). As such, we define
‘currency’ as “A material entity that is the bearer
of a concretization of money and is created by
some governmental organization or on behalf of
some governmental organization that has
authorized its creation.”
      </p>
    </sec>
    <sec id="sec-9">
      <title>4. Discussion</title>
      <p>There is a current need in biomedical
ontologies to represent EDH due to an increased
interest in their role in determining health
outcomes and contributing to health disparities. In
this paper, we reviewed several existing
representations in OWL ontologies for money and
financial transactions, but found none that were
broadly reusable based on our needs. The most
common reason, and one that was nearly
ubiquitous for each class identified, was that the
definition was too narrow in its scope. In the
majority of cases, this was due to the definition
omitting some aspect of what the term represents
that would make it generally applicable. In one
instance, (i.e., NCIt’s ‘Payment’) the class
definition was not informative.</p>
      <p>To fill this gap in the representation of
money- and finance-related entities, we created 7
new classes in OMRSE and imported an
additional four. These four imported classes were
not identified through the ontology database
search, but rather came from our familiarity with
existing OBO Foundry ontologies, such as OBI
and d-acts. We believe this highlights the value of
multi-collaborative efforts, like the OBO
Foundry, in developing ontologies that are
interoperable and specialized for a well-defined
domain. Of the 7 new classes, one represents
money, one represents debt obligations, one
represents currency, and four represent the
processes in which money can be used as a
medium of exchange, a payment of debt, or to
value other things. Our definitions are intended to
be domain-independent and are based on
established definitions from within economics so
that they are applicable to domains within and
outside of biomedicine. Because OMRSE uses
BFO for its top-level hierarchy, these classes can
be easily reused within other BFO-aligned
ontologies.</p>
      <p>As we’ve stated, our motivation for this work
stems from a broader need to represent EDH and
the data that are collected on them, such as
income, wealth, and the ability to pay for
resources like food, utilities, clothing, and
housing. Although explicitly representing this
information and the non-money-related entities
that they’re about (e.g., clothing items or food) is
future work, we believe the classes we’ve
proposed are necessary prerequisites and thus a
required starting point, to do so. For instance, we
would use our ‘money’ class to define ‘past year
income data item’ as “A data item that is about the
sum of the value of monies that a person or
household or organization acquired in a past
yearlong interval.”</p>
      <p>
        This work is not without limitations. Because
we classify ‘money’ as a debt, in line with modern
definitions of ‘money’ in finance and economics,
it is possible that there are older monetary systems
for which this definition does not apply. While a
comprehensive review of monetary systems
throughout history is beyond the scope of this
paper, we do note that this definition is
nevertheless consistent with many historic forms
of money, such as Babylonian clay tablets, tally
sticks, and cigarettes in World War II prison
camps (
        <xref ref-type="bibr" rid="ref9">9,30</xref>
        ). We also did not represent various
entities used as money, such as checks or bonds,
or financial assets, such as stocks, that would be
useful for more comprehensibly representing
financial transactions and wealth, respectively.
Such additions will be included as future work in
OMRSE as needed by various use cases for
representing EDH and possibly other
medicallyrelevant social entities.
      </p>
      <p>Additional future work to extend our
representation of money and finances will aim to
more completely represent other entities that are
used as money, digital transactions, financial
assets, and finance-related processes that are
relevant to medicine. We also are developing
classes in OMRSE to represent other EDH, such
as occupation and education, as well as intimate
partner violence.</p>
    </sec>
    <sec id="sec-10">
      <title>5. Acknowledgements</title>
      <p>This project is sponsored in part by the
University of Florida Clinical and Translational
Science Institute, which is supported in part by the
NIH National Center for Advancing Translational
Sciences under award number UL1TR001427.
The content is solely the responsibility of the
authors and does not necessarily represent the
official views of the National Institutes of Health.</p>
    </sec>
    <sec id="sec-11">
      <title>6. References</title>
      <p>[30] R.A. Radford, The Economic Organisation
of a P.O.W. Camp, Economica 12 (1945)
189–201.
[31] W. Ceusters, An information artifact
ontology perspective on data collections and
associated representational artifacts. In:
Quality of Life Through Quality of
Information, Proceedings of MIE2012, 2012.</p>
    </sec>
  </body>
  <back>
    <ref-list>
      <ref id="ref1">
        <mixed-citation>
          [1]
          <string-name>
            <given-names>N.E.</given-names>
            <surname>Adler</surname>
          </string-name>
          ,
          <string-name>
            <given-names>K.</given-names>
            <surname>Newman</surname>
          </string-name>
          , Socioeconomic Disparities In Health: Pathways And Policies,
          <source>Health Aff 21</source>
          (
          <year>2002</year>
          )
          <fpage>60</fpage>
          -
          <lpage>76</lpage>
          .
        </mixed-citation>
      </ref>
      <ref id="ref2">
        <mixed-citation>
          [2]
          <string-name>
            <given-names>J.W.</given-names>
            <surname>Lynch</surname>
          </string-name>
          ,
          <string-name>
            <given-names>G.A.</given-names>
            <surname>Kaplan</surname>
          </string-name>
          ,
          <string-name>
            <given-names>E.R.</given-names>
            <surname>Pamuk</surname>
          </string-name>
          ,
          <string-name>
            <given-names>R.D.</given-names>
            <surname>Cohen</surname>
          </string-name>
          ,
          <string-name>
            <given-names>K.E.</given-names>
            <surname>Heck</surname>
          </string-name>
          ,
          <string-name>
            <given-names>J.L.</given-names>
            <surname>Balfour</surname>
          </string-name>
          ,
          <string-name>
            <given-names>I.H.</given-names>
            <surname>Yen</surname>
          </string-name>
          , “
          <article-title>Income inequality and mortality in metropolitan areas of the United States</article-title>
          .”
          <source>Am J Public Health</source>
          <volume>88</volume>
          (
          <year>1998</year>
          ):
          <fpage>1074</fpage>
          -
          <lpage>1080</lpage>
          .
        </mixed-citation>
      </ref>
      <ref id="ref3">
        <mixed-citation>
          [3]
          <string-name>
            <given-names>N.</given-names>
            <surname>Kondo</surname>
          </string-name>
          , G. Sembajwe,
          <string-name>
            <given-names>I. Kawachi</given-names>
            , R.N. van
            <surname>Dam</surname>
          </string-name>
          ,
          <string-name>
            <given-names>S.V.</given-names>
            <surname>Subramanian</surname>
          </string-name>
          ,
          <string-name>
            <given-names>Z.</given-names>
            <surname>Yamagata</surname>
          </string-name>
          , “
          <article-title>Income inequality, mortality, and self rated health: meta-analysis of multilevel studies</article-title>
          .
          <source>” BMJ</source>
          .
          <volume>339</volume>
          (
          <year>2009</year>
          ):
          <fpage>b4471</fpage>
          .
        </mixed-citation>
      </ref>
      <ref id="ref4">
        <mixed-citation>
          <article-title>[4] NACHC, PRAPARE</article-title>
          . URL: https://www.nachc.org/research-anddata/prapare/
        </mixed-citation>
      </ref>
      <ref id="ref5">
        <mixed-citation>
          [5]
          <string-name>
            <given-names>U.</given-names>
            <surname>Mäki</surname>
          </string-name>
          ,
          <source>Reflections on the Ontology of Money. J Soc Ontol</source>
          .
          <volume>6</volume>
          (
          <year>2020</year>
          )
          <fpage>245</fpage>
          -
          <lpage>263</lpage>
          .
        </mixed-citation>
      </ref>
      <ref id="ref6">
        <mixed-citation>
          [6]
          <string-name>
            <given-names>R.G.</given-names>
            <surname>Hubbard</surname>
          </string-name>
          , Macroeconomics, 3rd ed.,
          <string-name>
            <surname>Prentice</surname>
            <given-names>Hall</given-names>
          </string-name>
          , Boston, MA,
          <year>2010</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref7">
        <mixed-citation>
          [7]
          <string-name>
            <given-names>N.G.</given-names>
            <surname>Mankiw</surname>
          </string-name>
          , Macroeconomics, 8th ed., Worth Publishers, New York, NY,
          <year>2013</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref8">
        <mixed-citation>
          [8]
          <string-name>
            <given-names>P.R.</given-names>
            <surname>Krugman</surname>
          </string-name>
          ,
          <string-name>
            <surname>R Wells</surname>
          </string-name>
          ,
          <source>Essentials of Economics</source>
          , 4th ed., Worth Publishers, New York, NY,
          <year>2017</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref9">
        <mixed-citation>
          [9]
          <string-name>
            <given-names>A.M.</given-names>
            <surname>Innes</surname>
          </string-name>
          . What Is Money?,
          <string-name>
            <surname>Bank Law</surname>
            <given-names>J</given-names>
          </string-name>
          ,
          <volume>24</volume>
          (
          <year>1913</year>
          )
          <fpage>419</fpage>
          -
          <lpage>421</lpage>
        </mixed-citation>
      </ref>
      <ref id="ref10">
        <mixed-citation>
          [10]
          <string-name>
            <surname>A.M. Innes</surname>
          </string-name>
          ,
          <source>The Credit Theory of Money</source>
          ,
          <source>Bank Law J</source>
          <volume>31</volume>
          (
          <year>1914</year>
          )
          <fpage>151</fpage>
          -
          <lpage>168</lpage>
        </mixed-citation>
      </ref>
      <ref id="ref11">
        <mixed-citation>
          [11]
          <article-title>Board of Governors of the Federal Reserve System, Currency</article-title>
          and
          <string-name>
            <given-names>Coin</given-names>
            <surname>Services</surname>
          </string-name>
          , URL: https://www.federalreserve.gov/paymentsyst ems/coin_about.htm
        </mixed-citation>
      </ref>
      <ref id="ref12">
        <mixed-citation>
          [12]
          <string-name>
            <surname>IMF</surname>
          </string-name>
          .
          <article-title>Classification of Financial Assets and Liabilities</article-title>
          , in: Monetary and Financial Statistics Manual &amp; Compilation Guide,
          <source>International Monetary Fund</source>
          ,
          <year>2016</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref13">
        <mixed-citation>
          [13]
          <string-name>
            <given-names>W.S.</given-names>
            <surname>Jevons</surname>
          </string-name>
          . XVI:
          <article-title>Representative Money</article-title>
          .
          <source>Money and the Mechanism of Exchange</source>
          .
          <year>1875</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref14">
        <mixed-citation>
          [14]
          <string-name>
            <given-names>A.</given-names>
            <surname>Hicks</surname>
          </string-name>
          ,
          <string-name>
            <given-names>J.</given-names>
            <surname>Hanna</surname>
          </string-name>
          ,
          <string-name>
            <given-names>D.</given-names>
            <surname>Welch</surname>
          </string-name>
          ,
          <string-name>
            <given-names>M.</given-names>
            <surname>Brochhausen</surname>
          </string-name>
          ,
          <string-name>
            <given-names>W.R.</given-names>
            <surname>Hogan</surname>
          </string-name>
          ,
          <article-title>The ontology of medically related social entities: recent developments</article-title>
          .
          <source>J Biomed Semant</source>
          <volume>7</volume>
          (
          <year>2016</year>
          ).
        </mixed-citation>
      </ref>
      <ref id="ref15">
        <mixed-citation>
          [15]
          <string-name>
            <given-names>N.</given-names>
            <surname>Matentzoglu</surname>
          </string-name>
          ,
          <string-name>
            <given-names>C.</given-names>
            <surname>Mungall</surname>
          </string-name>
          , D. GoutteGattat, Ontology Development Kit,
          <year>2021</year>
          . URL: https://github.com/INCATools/ontologydevelopment-kit
        </mixed-citation>
      </ref>
      <ref id="ref16">
        <mixed-citation>
          [16]
          <string-name>
            <given-names>B.</given-names>
            <surname>Smith</surname>
          </string-name>
          ,
          <string-name>
            <given-names>M.</given-names>
            <surname>Ashburner</surname>
          </string-name>
          ,
          <string-name>
            <given-names>C.</given-names>
            <surname>Rosse</surname>
          </string-name>
          ,
          <string-name>
            <given-names>J.</given-names>
            <surname>Bard</surname>
          </string-name>
          ,
          <string-name>
            <given-names>W.</given-names>
            <surname>Bug</surname>
          </string-name>
          ,
          <string-name>
            <given-names>W</given-names>
            <surname>Ceusters</surname>
          </string-name>
          ,
          <string-name>
            <given-names>L.J.</given-names>
            <surname>Goldberg</surname>
          </string-name>
          ,
          <string-name>
            <given-names>K.</given-names>
            <surname>Eilbeck</surname>
          </string-name>
          ,
          <string-name>
            <given-names>A.</given-names>
            <surname>Ireland</surname>
          </string-name>
          ,
          <string-name>
            <given-names>C.J.</given-names>
            <surname>Mungall</surname>
          </string-name>
          , OBI Consortium,
          <string-name>
            <given-names>N.</given-names>
            <surname>Leontis</surname>
          </string-name>
          ,
          <string-name>
            <given-names>P.</given-names>
            <surname>Rocca-Serra</surname>
          </string-name>
          ,
          <string-name>
            <given-names>A.</given-names>
            <surname>Ruttenberg</surname>
          </string-name>
          ,
          <string-name>
            <given-names>S.</given-names>
            <surname>Sansone</surname>
          </string-name>
          ,
          <string-name>
            <given-names>R.H.</given-names>
            <surname>Scheuermann</surname>
          </string-name>
          ,
          <string-name>
            <given-names>N.</given-names>
            <surname>Shah</surname>
          </string-name>
          ,
          <string-name>
            <given-names>P.L.</given-names>
            <surname>Whetzel</surname>
          </string-name>
          ,
          <string-name>
            <given-names>S.</given-names>
            <surname>Lewis</surname>
          </string-name>
          , ”
          <article-title>The OBO Foundry: coordinated evolution of ontologies to support biomedical data integration</article-title>
          .
          <source>” Nat Biotechnol</source>
          <volume>25</volume>
          (
          <year>2007</year>
          ):
          <fpage>1251</fpage>
          -
          <lpage>1255</lpage>
          .
        </mixed-citation>
      </ref>
      <ref id="ref17">
        <mixed-citation>
          [17]
          <string-name>
            <given-names>R.</given-names>
            <surname>Arp</surname>
          </string-name>
          ,
          <string-name>
            <given-names>B.</given-names>
            <surname>Smith</surname>
          </string-name>
          ,
          <string-name>
            <given-names>A.D.</given-names>
            <surname>Spear</surname>
          </string-name>
          ,
          <article-title>Building Ontologies with Basic Formal Ontology</article-title>
          , The MIT Press,
          <year>2015</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref18">
        <mixed-citation>
          [18]
          <string-name>
            <given-names>E.</given-names>
            <surname>Ong</surname>
          </string-name>
          ,
          <string-name>
            <given-names>Z.</given-names>
            <surname>Xiang</surname>
          </string-name>
          ,
          <string-name>
            <given-names>B.</given-names>
            <surname>Zhao</surname>
          </string-name>
          ,
          <string-name>
            <given-names>Y.</given-names>
            <surname>Liu</surname>
          </string-name>
          ,
          <string-name>
            <given-names>Y.</given-names>
            <surname>Lin</surname>
          </string-name>
          ,
          <string-name>
            <given-names>J.</given-names>
            <surname>Zheng</surname>
          </string-name>
          ,
          <string-name>
            <given-names>C.</given-names>
            <surname>Mungall</surname>
          </string-name>
          ,
          <string-name>
            <given-names>M.</given-names>
            <surname>Courtot</surname>
          </string-name>
          ,
          <string-name>
            <given-names>A.</given-names>
            <surname>Ruttenberg</surname>
          </string-name>
          ,
          <string-name>
            <given-names>Y.</given-names>
            <surname>He</surname>
          </string-name>
          ,
          <article-title>Ontobee: A linked ontology data server to support ontology term dereferencing, linkage</article-title>
          ,
          <source>query and integration Nucleic Acids Research</source>
          <volume>45</volume>
          (
          <year>2017</year>
          )
          <fpage>D347</fpage>
          -
          <lpage>D352</lpage>
          . URL: https://academic.oup.com/nar/article/45/D1/ D347/2770665
        </mixed-citation>
      </ref>
      <ref id="ref19">
        <mixed-citation>
          [19]
          <string-name>
            <given-names>S.</given-names>
            <surname>Jupp</surname>
          </string-name>
          ,
          <string-name>
            <given-names>T.</given-names>
            <surname>Burdett</surname>
          </string-name>
          ,
          <string-name>
            <given-names>C.</given-names>
            <surname>Leroy</surname>
          </string-name>
          ,
          <string-name>
            <given-names>H.</given-names>
            <surname>Parkinson</surname>
          </string-name>
          ,
          <article-title>A new Ontology Lookup Service at EMBLEBI</article-title>
          , in: SWAT4LS,
          <year>2015</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref20">
        <mixed-citation>
          [20]
          <string-name>
            <given-names>N.F.</given-names>
            <surname>Noy</surname>
          </string-name>
          ,
          <string-name>
            <given-names>N.H.</given-names>
            <surname>Shah</surname>
          </string-name>
          ,
          <string-name>
            <given-names>P.L.</given-names>
            <surname>Whetzel</surname>
          </string-name>
          ,
          <string-name>
            <given-names>B.</given-names>
            <surname>Dai</surname>
          </string-name>
          ,
          <string-name>
            <given-names>M.</given-names>
            <surname>Dorf</surname>
          </string-name>
          ,
          <string-name>
            <given-names>N.</given-names>
            <surname>Griffith</surname>
          </string-name>
          ,
          <string-name>
            <given-names>C.</given-names>
            <surname>Jonquet</surname>
          </string-name>
          ,
          <string-name>
            <given-names>D.L.</given-names>
            <surname>Rubin</surname>
          </string-name>
          ,
          <string-name>
            <given-names>M.</given-names>
            <surname>Storey</surname>
          </string-name>
          ,
          <string-name>
            <given-names>C.G.</given-names>
            <surname>Chute</surname>
          </string-name>
          ,
          <string-name>
            <given-names>M.A.</given-names>
            <surname>Musen</surname>
          </string-name>
          ,
          <article-title>BioPortal: ontologies and integrated data resources at the click of a mouse Nucleic Acids Res 37 (</article-title>
          <year>2009</year>
          )
          <fpage>W170</fpage>
          -
          <lpage>173</lpage>
          .
        </mixed-citation>
      </ref>
      <ref id="ref21">
        <mixed-citation>[21] robot, Filter. URL: http://robot.obolibrary.org/filter.html</mixed-citation>
      </ref>
      <ref id="ref22">
        <mixed-citation>
          [22]
          <string-name>
            <given-names>R.C</given-names>
            .
            <surname>Jackson</surname>
          </string-name>
          ,
          <string-name>
            <given-names>J.P.</given-names>
            <surname>Balhoff</surname>
          </string-name>
          ,
          <string-name>
            <given-names>E.</given-names>
            <surname>Douglass</surname>
          </string-name>
          ,
          <string-name>
            <given-names>N.L.</given-names>
            <surname>Harris</surname>
          </string-name>
          ,
          <string-name>
            <given-names>C.J.</given-names>
            <surname>Mungall</surname>
          </string-name>
          ,
          <string-name>
            <given-names>J.A.</given-names>
            <surname>Overton</surname>
          </string-name>
          ,
          <article-title>ROBOT: A Tool for Automating Ontology Workflows</article-title>
          .
          <source>BMC Bioinformatics</source>
          <volume>20</volume>
          (
          <year>2019</year>
          ). URL: https://link.springer.com/epdf/10.1186/s128 59-
          <fpage>019</fpage>
          -3002-3
        </mixed-citation>
      </ref>
      <ref id="ref23">
        <mixed-citation>
          [23]
          <string-name>
            <given-names>B.</given-names>
            <surname>Smith</surname>
          </string-name>
          ,
          <string-name>
            <given-names>W.</given-names>
            <surname>Ceusters</surname>
          </string-name>
          ,
          <article-title>Ontological realism: A methodology for coordinated evolution of scientific ontologies</article-title>
          .
          <source>Appl Ontol</source>
          <volume>5</volume>
          (
          <year>2010</year>
          )
          <fpage>139</fpage>
          -
          <lpage>188</lpage>
          .
        </mixed-citation>
      </ref>
      <ref id="ref24">
        <mixed-citation>
          [24]
          <string-name>
            <given-names>M.A.</given-names>
            <surname>Musen</surname>
          </string-name>
          ,
          <article-title>The Protégé Project: A Look Back and a Look Forward</article-title>
          .
          <source>AI Matters</source>
          .
          <volume>1</volume>
          (
          <issue>2015</issue>
          )
          <fpage>4</fpage>
          -
          <lpage>12</lpage>
          .
        </mixed-citation>
      </ref>
      <ref id="ref25">
        <mixed-citation>
          [25]
          <string-name>
            <given-names>A.</given-names>
            <surname>Bandrowski</surname>
          </string-name>
          ,
          <string-name>
            <given-names>R.</given-names>
            <surname>Brinkman</surname>
          </string-name>
          ,
          <string-name>
            <given-names>M.</given-names>
            <surname>Brochhausen</surname>
          </string-name>
          ,
          <string-name>
            <given-names>M.H.</given-names>
            <surname>Brush</surname>
          </string-name>
          ,
          <string-name>
            <given-names>B.</given-names>
            <surname>Bug</surname>
          </string-name>
          ,
          <string-name>
            <given-names>M.C.</given-names>
            <surname>Chibucos</surname>
          </string-name>
          ,
          <string-name>
            <given-names>K.</given-names>
            <surname>Clancy</surname>
          </string-name>
          ,
          <string-name>
            <given-names>M.</given-names>
            <surname>Courtot</surname>
          </string-name>
          ,
          <string-name>
            <given-names>D.</given-names>
            <surname>Derom</surname>
          </string-name>
          ,
          <string-name>
            <given-names>M.</given-names>
            <surname>Dumontier</surname>
          </string-name>
          ,
          <string-name>
            <given-names>L.</given-names>
            <surname>Fan</surname>
          </string-name>
          ,
          <string-name>
            <given-names>J.</given-names>
            <surname>Fostel</surname>
          </string-name>
          ,
          <string-name>
            <given-names>G.</given-names>
            <surname>Fragoso</surname>
          </string-name>
          ,
          <string-name>
            <given-names>F.</given-names>
            <surname>Gibson</surname>
          </string-name>
          ,
          <string-name>
            <given-names>A.</given-names>
            <surname>Gonzalez-Beltran</surname>
          </string-name>
          ,
          <string-name>
            <given-names>M.A.</given-names>
            <surname>Haendel</surname>
          </string-name>
          ,
          <string-name>
            <given-names>Y.</given-names>
            <surname>He</surname>
          </string-name>
          ,
          <string-name>
            <given-names>M.</given-names>
            <surname>Heiskanen</surname>
          </string-name>
          ,
          <string-name>
            <given-names>T.</given-names>
            <surname>Hernandez-Boussard</surname>
          </string-name>
          ,
          <string-name>
            <given-names>M.</given-names>
            <surname>Jensen</surname>
          </string-name>
          ,
          <string-name>
            <given-names>Y.</given-names>
            <surname>Lin</surname>
          </string-name>
          ,
          <string-name>
            <given-names>A.L.</given-names>
            <surname>Lister</surname>
          </string-name>
          ,
          <string-name>
            <given-names>P.</given-names>
            <surname>Lord</surname>
          </string-name>
          ,
          <string-name>
            <given-names>J.</given-names>
            <surname>Malone</surname>
          </string-name>
          , E. Manduchi,
          <string-name>
            <given-names>M.</given-names>
            <surname>McGee</surname>
          </string-name>
          ,
          <string-name>
            <given-names>N.</given-names>
            <surname>Morrison</surname>
          </string-name>
          ,
          <string-name>
            <given-names>J.A.</given-names>
            <surname>Overton</surname>
          </string-name>
          ,
          <string-name>
            <given-names>H.</given-names>
            <surname>Parkinson</surname>
          </string-name>
          ,
          <string-name>
            <given-names>B.</given-names>
            <surname>Peters</surname>
          </string-name>
          ,
          <string-name>
            <given-names>P.</given-names>
            <surname>Rocca-Serra</surname>
          </string-name>
          ,
          <string-name>
            <given-names>A.</given-names>
            <surname>Ruttenberg</surname>
          </string-name>
          ,
          <string-name>
            <given-names>S.A.</given-names>
            <surname>Sansone</surname>
          </string-name>
          ,
          <string-name>
            <given-names>R.H.</given-names>
            <surname>Scheuermann</surname>
          </string-name>
          ,
          <string-name>
            <given-names>D.</given-names>
            <surname>Schober</surname>
          </string-name>
          ,
          <string-name>
            <given-names>B.</given-names>
            <surname>Smith</surname>
          </string-name>
          ,
          <string-name>
            <given-names>L.N.</given-names>
            <surname>Soldatova</surname>
          </string-name>
          ,
          <string-name>
            <given-names>C.J. Stoeckert</given-names>
            <surname>Jr</surname>
          </string-name>
          ,
          <string-name>
            <given-names>C.F.</given-names>
            <surname>Taylor</surname>
          </string-name>
          , C. Torniai,
          <string-name>
            <given-names>J.A.</given-names>
            <surname>Turner</surname>
          </string-name>
          ,
          <string-name>
            <given-names>R.</given-names>
            <surname>Vita</surname>
          </string-name>
          ,
          <string-name>
            <given-names>P.L.</given-names>
            <surname>Whetzel</surname>
          </string-name>
          ,
          <string-name>
            <given-names>J.</given-names>
            <surname>Zheng</surname>
          </string-name>
          ,
          <article-title>The Ontology for Biomedical Investigations</article-title>
          .
          <source>PLoS One</source>
          <volume>11</volume>
          (
          <year>2016</year>
          ). doi:
          <volume>10</volume>
          .1371/journal.pone.
          <volume>0154556</volume>
          .
        </mixed-citation>
      </ref>
      <ref id="ref26">
        <mixed-citation>
          [26]
          <string-name>
            <given-names>C.</given-names>
            <surname>Kronk</surname>
          </string-name>
          ,
          <string-name>
            <given-names>G.Q.</given-names>
            <surname>Tran</surname>
          </string-name>
          , D.T.Y. Wu,
          <article-title>Creating a Queer Ontology: The Gender, Sex, and Sexual Orientation (GSSO) Ontology</article-title>
          .
          <source>Stud Health Technol Inform</source>
          <volume>264</volume>
          (
          <year>2019</year>
          )
          <fpage>208</fpage>
          -
          <lpage>212</lpage>
          . URL: https://pubmed.ncbi.nlm.nih.gov/31437915/
        </mixed-citation>
      </ref>
      <ref id="ref27">
        <mixed-citation>
          [27]
          <string-name>
            <given-names>National</given-names>
            <surname>Cancer</surname>
          </string-name>
          <string-name>
            <surname>Institute</surname>
          </string-name>
          , NCI Thesaurus. URL: https://ncithesaurus.nci.nih.gov/ncitbrowser/
        </mixed-citation>
      </ref>
      <ref id="ref28">
        <mixed-citation>
          [28]
          <string-name>
            <given-names>Y.</given-names>
            <surname>Lin</surname>
          </string-name>
          ,
          <string-name>
            <given-names>M.R.</given-names>
            <surname>Harris</surname>
          </string-name>
          ,
          <string-name>
            <given-names>F.J.</given-names>
            <surname>Manion</surname>
          </string-name>
          ,
          <string-name>
            <given-names>E.</given-names>
            <surname>Eisenhauer</surname>
          </string-name>
          ,
          <string-name>
            <given-names>B.</given-names>
            <surname>Zhao</surname>
          </string-name>
          ,
          <string-name>
            <given-names>W.</given-names>
            <surname>Shi</surname>
          </string-name>
          ,
          <string-name>
            <given-names>A.</given-names>
            <surname>Karnovsky</surname>
          </string-name>
          ,
          <string-name>
            <given-names>Y.</given-names>
            <surname>He</surname>
          </string-name>
          ,
          <article-title>Development of a BFO-Based Informed Consent Ontology (ICO)</article-title>
          .
          <source>In: CEUR, Proceedings of the 5th International Conference on Biomedical Ontology</source>
          ,
          <year>2014</year>
          . URL: http://ceur-ws.
          <source>org/</source>
          Vol-
          <volume>1327</volume>
          /#
          <fpage>4</fpage>
        </mixed-citation>
      </ref>
      <ref id="ref29">
        <mixed-citation>
          [29]
          <string-name>
            <given-names>E.</given-names>
            <surname>Norris</surname>
          </string-name>
          ,
          <string-name>
            <surname>M.M. Marques</surname>
            ,
            <given-names>A.N.</given-names>
          </string-name>
          <string-name>
            <surname>Finnerty</surname>
            ,
            <given-names>A.J.</given-names>
          </string-name>
          <string-name>
            <surname>Wright</surname>
            ,
            <given-names>R.</given-names>
          </string-name>
          <string-name>
            <surname>West</surname>
            ,
            <given-names>J.</given-names>
          </string-name>
          <string-name>
            <surname>Hastings</surname>
            ,
            <given-names>P.</given-names>
          </string-name>
          <string-name>
            <surname>Williams</surname>
            ,
            <given-names>R.N.</given-names>
          </string-name>
          <string-name>
            <surname>Carey</surname>
            ,
            <given-names>M.P.</given-names>
          </string-name>
          <string-name>
            <surname>Kelly</surname>
            ,
            <given-names>M.</given-names>
          </string-name>
          <string-name>
            <surname>Johnston</surname>
            ,
            <given-names>S.</given-names>
          </string-name>
          <string-name>
            <surname>Michie</surname>
          </string-name>
          ,
          <article-title>Development of an Intervention Setting Ontology for behaviour change: Specifying where interventions take place</article-title>
          .
          <source>Wellcome Open Res</source>
          <volume>5</volume>
          (
          <year>2020</year>
          ).
        </mixed-citation>
      </ref>
    </ref-list>
  </back>
</article>