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    <article-meta>
      <title-group>
        <article-title>Technology Assisted Review Systems: Current and Future Directions</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Giorgio Maria Di Nunzio</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>Department of Information Engineering, University of Padua, Italy</institution>
          ,
          <addr-line>Via Gradenigo 6a, 35131, Padova</addr-line>
          ,
          <country country="IT">Italy</country>
        </aff>
      </contrib-group>
      <abstract>
        <p>Technology-Assisted Review (TAR) systems are becoming indispensable in domains demanding extensive document screening with high precision, notably in eDiscovery and systematic biomedical reviews. Recent advancements in machine learning, particularly the emergence of Large Language Models (LLMs), have expanded the capabilities of TAR systems, enabling them to handle voluminous text data more eficiently and accurately. Despite these strides, significant challenges remain, including the development of efective stopping criteria, availability of high-quality domain-specific datasets, and robust evaluation metrics to ensure reproducibility and defensibility in high-stakes applications. This paper surveys recent trends and emerging methodologies in TAR, with an emphasis on approaches aimed at improving document relevance screening, query generation, and validation protocols across active learning (AL) and reinforcement learning (RL) frameworks. We examine the utilization of LLMs for Boolean query refinement and abstract screening, particularly in enhancing systematic review workflows. Additionally, we discuss the role of specialized datasets and data-driven approaches in addressing the unique requirements of TAR systems in fields like biomedical research and eDiscovery.</p>
      </abstract>
      <kwd-group>
        <kwd>eol&gt;Technology Assisted Review Systems</kwd>
        <kwd>eDiscovery</kwd>
        <kwd>Systematic Reviews</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>1. Introduction</title>
      <p>
        Technology-Assisted Review (TAR) systems are increasingly essential in domains where extensive
document screening and high precision are paramount, such as eDiscovery and systematic review in
biomedical research [
        <xref ref-type="bibr" rid="ref1 ref2 ref3 ref4">1, 2, 3, 4</xref>
        ]. The advent of advanced machine learning techniques, particularly
Large Language Models (LLMs), has expanded the potential of TAR systems, enabling them to handle
large volumes of text more eficiently and accurately than before. Despite these advancements, key
challenges persist, including the need for reliable stopping rules, high-quality domain-specific datasets,
and robust evaluation metrics to ensure reproducibility and defensibility in high-stakes applications.
      </p>
      <p>This paper presents a survey on recent trends and emerging methodologies in TAR, focusing on
techniques and frameworks aimed at enhancing document relevance screening, query formation, and
validation protocols across various active learning (AL) and reinforcement learning (RL) settings. We
review recent innovations in leveraging LLMs for Boolean query training and abstract screening,
shedding light on how these models can improve systematic review workflows through more efective
query generation and precision in relevance assessment. Additionally, we examine the role of specialized
datasets and data-driven approaches, underscoring their importance in addressing TAR challenges
specific to biomedical research and eDiscovery.</p>
      <p>Beyond the technical advancements in model design and data handling, the survey explores the
critical issue of evaluation metrics and reproducibility in TAR systems. By analyzing diferent metrics,
including precision-at-recall and task-aligned model selection, we aim to provide insights into best
practices that enhance TAR system reliability. Our discussion extends to established protocols and
3rd Workshop on Augmented Intelligence for Technology-Assisted Review Systems (ALTARS 2024): Evaluation Metrics and Protocols
for eDiscovery and Systematic Review Systems. March 28, 2024, Glasgow, UK.
* Corresponding author.
$ giorgiomaria.dinunzio@unipd.it (G. M. Di Nunzio)
 https://www.dei.unipd.it/~dinunzio/ (G. M. Di Nunzio)
0000-0002-0877-7063 (G. M. Di Nunzio)</p>
      <p>© 2024 Copyright for this paper by its authors. Use permitted under Creative Commons License Attribution 4.0 International (CC BY 4.0).
frameworks that support the implementation of TAR in complex legal environments, where concerns
about consistency, privacy, and defensibility are paramount.</p>
      <p>Finally, we conduct a comparative analysis of current TAR tools, with attention to feedback
mechanisms and dense retrieval models that improve document screening prioritization. By reviewing these
tools across varying TAR contexts, we highlight both the strengths and areas for further improvement,
contributing to the field’s ongoing eforts to refine TAR systems for greater accuracy and applicability.</p>
      <p>This survey ofers a comprehensive view of the current landscape and future directions for TAR
systems, providing a foundation for practitioners and researchers aiming to harness advanced technologies
for enhanced document screening eficiency and precision in systematic reviews and eDiscovery.</p>
      <sec id="sec-1-1">
        <title>1.1. Methodology</title>
        <p>
          In this review of the current state of the art of technology assisted review systems, we focus on the last
year of research papers presented in international conferences and journals. Given the nature of this
work which had the goal to bring the most recent material for a discussion at the third workshop on
Augmented Intelligence for Technology Assisted Review Systems (ALTARS 2024) [
          <xref ref-type="bibr" rid="ref3">3</xref>
          ], we decided to
search on Google Scholar all the paper in 2024 that contained the string "technology assisted review".
After filtering work that did not fit our goal and our criteria (international conference and journals), we
ended up with 16 research papers.
        </p>
        <p>
          We would also like to mention a work that is not included in the following sections but that we
consider an important element for a broader perspective on the past, present, and future of TAR systems.
It is the work presented by [
          <xref ref-type="bibr" rid="ref5">5</xref>
          ] ofer a foundational survey that synthesizes AI-driven methods for
systematic review (SR) automation, covering NLP, ML, and DL applications across SR stages. Their
study includes an analysis of 52 works, showing most eforts center on automating screening, with less
focus on the search, data extraction, and risk of bias assessment. To enhance this overview, the authors
conducted an online survey among SR practitioners and researchers, gathering practical insights on
current practices, challenges, and future needs.
        </p>
        <p>The survey results, paired with literature analysis, expose key gaps—such as limited use of large
language models (LLMs), lack of multilingual datasets, and insuficient integration of image processing.
Saeidmehr et al. propose future directions, including expanding AI to new SR stages, incorporating
domain knowledge, developing language-agnostic models, and enhancing data extraction from visual
data in scientific publications. Their survey thus serves as a dual resource: equipping researchers
with an understanding of AI in SR automation and guiding computer scientists to innovate within this
evolving field. This work will serve as our foundation for assessing and advancing the methods and
protocols for AI-enhanced SR automation.</p>
      </sec>
    </sec>
    <sec id="sec-2">
      <title>2. Current State-of-the-Art</title>
      <sec id="sec-2-1">
        <title>2.1. Large Language Models (LLMs) and Boolean Query Training</title>
        <p>In this section, we discuss innovative methods for leveraging LLMs to improve the eficiency of
document relevance screening in systematic reviews. Two significant studies contribute to this field, each
emphasizing unique aspects of query formation and question-answering frameworks in LLMs.</p>
        <p>
          First, the work by [
          <xref ref-type="bibr" rid="ref6">6</xref>
          ] focuses on utilizing LLMs to generate structured Boolean queries that resemble
those used by systematic reviewers. Their methodology involves creating a dataset with natural
language review descriptions paired with Boolean searches, allowing for the training and evaluation of
LLMs like MistralInstruct-7b to map these descriptions efectively. Empirical evaluations and librarian
interviews reveal that while the model demonstrates promising results, it is not yet fully ready for
integration into review workflows. Medical librarians provided valuable feedback, suggesting further
improvements to the dataset, including fields like population and intervention, which could enhance
performance. The study emphasizes the importance of continuous engagement with expert librarians,
as well as review methodologists and students, to better understand user needs. These interactions
could inform improvements, such as post-processing integration and database compatibility, facilitating
simultaneous query refinement and abstract screening.
        </p>
        <p>
          The other work authored by [
          <xref ref-type="bibr" rid="ref7">7</xref>
          ] introduce an LLM-driven question-answering framework specifically
designed to automate abstract screening in a zero-shot setting. Their approach represents a pioneering
method for transforming selection criteria into binary questions, scoring answers using LLMs, re-ranking
based on question and criteria, and ultimately prioritizing studies for review. By applying LLMs to screen
abstracts according to predefined inclusion and exclusion criteria, they achieve substantial eficiency
improvements in reference prioritization. GPT-3.5, for instance, demonstrates a high capability for
managing mixed criteria, accurately processing complex queries to isolate relevant studies. Comparative
analyses across diferent LLMs underscore the potential for model diversity to enhance accuracy,
suggesting that each model’s strengths could be selectively harnessed to improve screening outcomes.
        </p>
        <p>These studies suggest a promising future for integrating LLMs into systematic review workflows.
By generating high-quality queries and facilitating precise abstract screening, these models hold
significant potential for improving the speed and accuracy of systematic review processes, though
further refinement and stakeholder feedback are necessary to optimize their utility.</p>
      </sec>
      <sec id="sec-2-2">
        <title>2.2. Stopping Rules in Technology-Assisted Review (TAR)</title>
        <p>The "Stopping Rules in Technology-Assisted Review (TAR)" section explores innovative approaches for
determining when to halt document screening in TAR, addressing both reinforcement learning (RL)
and heuristic methods tailored to diferent active learning settings.</p>
        <p>
          In [
          <xref ref-type="bibr" rid="ref8">8</xref>
          ], the authors introduce RLStop, a pioneering TAR stopping rule grounded in reinforcement
learning. The RLStop approach is designed to assist reviewers in deciding whether to continue screening
documents or halt when a predefined target recall is met. The RL model treats each decision as a sequence,
examining ranked documents in batches to assess recall levels collectively. Once a batch’s relevance
judgments are obtained, the RL agent determines if screening should proceed or stop. Empirical tests
demonstrate RLStop’s substantial workload reduction in comparison to existing methods, as it efectively
identifies stopping points across multiple datasets and recall levels. While this approach shows notable
promise, RLStop requires training data from previous relevance screenings and specific recall level
configurations, which limits its applicability in settings without such resources. Future research will
address these constraints, potentially enhancing RLStop’s adaptability across diverse TAR environments.
        </p>
        <p>The paper written by [9] propose SAFE, a conservative stopping heuristic that merges various
heuristics to prevent early termination and missed relevant records. SAFE’s procedure is composed of
four steps: generating a training set, applying active learning, expanding the search with a diferent
model, and quality evaluation. SAFE is designed to balance the risks of continued screening with the
probability of missing relevant data, thus supporting reviewers in making data-driven stopping decisions.
Notably, SAFE aligns with PRISMA 2020 and Open Science standards to ensure AI transparency and
reproducibility. Unlike RL-based approaches, SAFE is suitable for active learning-assisted screening and
can adapt to diferent review types, such as updating systematic reviews. The method is accessible to
non-experts, making it a practical tool for researchers across varied fields. However, SAFE may not be
universally applicable and is limited to specific datasets and active learning models, calling for further
research to generalize its use.</p>
        <p>In [10], the authors introduce a stopping strategy called SAL within the context of Active Learning
(AL) workflows in TAR. They tackle the critical "when-to-stop" issue, which balances the need for
costefective annotation with reaching a desired recall level, by adapting the Saerens–Latinne–Decaestecker
(SLD) algorithm to TAR processes. This approach efectively addresses earlier limitations noted in prior
works by improving stopping precision, particularly for medium to high recall targets (0.8 and 0.9).
However, for higher recall levels, SAL may halt prematurely, which Molinari et al. address with the
refined SALR  , achieving a more balanced trade-of without significantly escalating annotation costs.
Future work on SAL aims to explore more nuanced methods to prevent recall overestimation and to
test its compatibility with additional sampling techniques, potentially enhancing its application across
varied TAR and eDiscovery tasks. Integrating SAL and SALR into TAR workflows exemplifies how
strategic stopping decisions can optimize both cost and recall, addressing the critical question of "when
to stop" eficiently in large-scale annotation settings.</p>
        <p>Finally, [11] examines an alternative target-based method inspired by Cormack and Grossman’s
“reliability score,” which measures the likelihood of reaching suficient recall within TAR. Their approach
involves setting a target recall level and using a reliability score to guide when to stop screening. This
algorithm leverages mathematical formulas to gauge performance and allows stopping when all target
records are retrieved or resources are exhausted. Their results indicate strong reliability, with both
theoretical and practical validations, though future work is needed to refine the algorithm for broader
application. This target-based method enhances the precision of stopping rules, providing reviewers
with quantifiable stopping criteria based on recall probability, though it is limited by initial assumptions
regarding the distribution of relevant records.</p>
        <p>These approaches ofer varied yet complementary stopping solutions, from RL-based strategies for
adaptive decisions to heuristic and reliability-score-based methods that prioritize transparency and
performance. In this regard, these papers contribute valuable tools for optimizing document screening
in TAR.</p>
      </sec>
      <sec id="sec-2-3">
        <title>2.3. Dataset and Data-Driven Approaches</title>
        <p>In this section, we explore specialized datasets for Technology-Assisted Reviews in biomedical research
and simulation-based studies focusing on active learning (AL) models for identifying elusive documents
in systematic reviews.</p>
        <p>In [12], the authors introduce FASS-BSLR, a dataset tailored to support TAR in biomedical systematic
literature reviews (SLRs), with a focus on Covid-19. This dataset includes 111 biomedical SLRs, their
relevant studies, and Boolean queries derived from PubMed based on titles and keywords. It also
incorporates Boolean queries generated by generative language models, including a subset crafted by
experts, known as Set-B, to enable eficient searches. The authors also explore the use of ChatGPT
for generating Boolean queries (referred to as CGT) and demonstrate its eficacy over traditional and
automated search methods. Specifically, CGT significantly outperforms other models on most metrics
in FASS-BSLR, except when measured at rank 1000, where manual queries show slight advantages. A
distinctive contribution of the paper is its assessment of CGT’s performance in scenarios with varying
numbers of seed documents; results indicate that even a small number of seed documents substantially
enhance CGT’s efectiveness. This study ofers a comprehensive dataset and an innovative Boolean
query generation method, laying a foundation for further TAR research in the biomedical domain.</p>
        <p>[13] addresses the challenges of identifying hard-to-find documents within AL frameworks. Their
simulation study assesses how diferent AL models and levels of prior knowledge influence the "Time to
Discovery" (TD) for elusive relevant documents. The study highlights that certain models, particularly
those combining random forests and support vector machines, perform better at reducing TD for these
hard-to-find documents. Conversely, other AL models exhibit variability in finding these challenging
papers, with TD fluctuating significantly across simulations, indicating inconsistency in model
performance. The findings suggest that documents with higher TD values vary significantly across diferent
AL models, hinting at content-based factors—like title and abstract characteristics—that may afect
discoverability. The authors advocate for future research focused on analyzing these content features to
understand why certain relevant documents remain challenging to locate, which could inform model
improvements and better data preprocessing techniques.</p>
        <p>These works provide valuable insights for dataset development and model optimization in TAR, with
FASS-BSLR facilitating systematic review searches and AL models potentially addressing challenges in
retrieving elusive papers. These approaches underscore the importance of both high-quality,
domainspecific datasets and targeted model adjustments to enhance TAR outcomes.</p>
      </sec>
      <sec id="sec-2-4">
        <title>2.4. Evaluation Metrics and Reproducibility</title>
        <p>To enhance TAR methodologies, understanding the impact of various evaluation metrics and ensuring
reproducibility in research are crucial elements. Diferent evaluation metrics, as well as validation
protocols used in reproducibility studies, directly shape TAR performance outcomes, model reliability,
and their defensibility in high-stakes settings like eDiscovery and systematic review screening.</p>
        <p>In [14], the authors emphasize the importance of balanced evaluation metrics, particularly introducing
normalized Precision at Recall (nP@r%) and a variant, snP@r%. Their work illustrates that while recall is
a key measure, nP@r% - the product of precision and true negative rate - provides a more comprehensive
metric that aligns with high-recall TAR scenarios. The authors argue that nP@r% and snP@r% are less
afected by dataset characteristics, making them more suitable for assessing TAR system performance,
particularly where both precision and the exclusion of false positives are critical. This robustness
allows for more accurate benchmarking of IR models and supports more eficient decision-making
for document screening, especially in cases where incorrect retrieval could have legal or financial
implications.</p>
        <p>On the reproducibility front, [15] explores the challenges in replicating results across diferent TAR
tasks, finding that while a “Goldilocks epoch” for pretraining BERT-based models often enhances
TAR outcomes, the exact optimal epoch can vary significantly depending on the dataset and
preprocessing. In the study, the authors underscore the limitations of “domain-mismatch” between general
pre-trained models (like BERT) and specific tasks, and highlights BioLinkBERT as a domain-optimized
alternative that performs well without further pre-training, suggesting that simpler, task-aligned models
can efectively enhance reproducibility and reduce computational demands. This study supports a
transparent, domain-sensitive model selection as a more efective approach than exhaustive model
tuning, especially for medical and scientific literature reviews where reproducibility is essential for
reliable results.</p>
        <p>Finally, [16] examines the efectiveness of proprietary TAR tools and their associated validation
protocols, particularly focusing on the Elusion test, a common method for estimating recall. Their
study, conducted with live litigation data, reveals that certain vendor software can be less efective than
open-source algorithms like Continuous Active Learning in real-world applications. Additionally, they
critique the Elusion test for its tendency to yield inconsistent recall results, potentially undermining
defensibility in legal contexts. This highlights the need for reproducible, transparent validation practices
to ensure reliability and prevent overestimation of recall in professional eDiscovery.</p>
        <p>The papers presented in this section show the importance of tailored evaluation metrics, reproducible
model pipelines, and reliable validation practices for robust TAR system performance. By focusing on
metrics like nP@r%, task-aligned model selection, and defensible validation protocols, the TAR field can
better support accuracy and reliability in real-world applications, from biomedical research to litigation.</p>
      </sec>
      <sec id="sec-2-5">
        <title>2.5. Protocols and Frameworks for TAR Implementation</title>
        <p>In this section, we present studies that cover established protocols in TAR, especially those used in
e-discovery, focusing on categorization, validation methods, and challenges in legal contexts.</p>
        <p>[17] introduce an error-tolerant TAR protocol that incorporates accountability mechanisms by
designing a label-verification process within the Continuous Active Learning (CAL) framework. Their
work addresses challenges within non-realizable classification cases, where no perfect classifier exists,
by accommodating potential human errors in labeling and detecting strategic mislabeling attempts by
parties in litigation. This approach adapts secure multi-party computation concepts, aiming to balance
high recall with minimized disclosure of non-responsive documents, which is especially important for
preserving privacy and confidentiality. Notably, this label-verification protocol detects errors with high
probability and provides a way to counteract attempts at misclassification, enhancing both accuracy
and accountability in eDiscovery settings.</p>
        <p>In [18], the authors investigate categorization eficiency within large-scale eDiscovery, focusing
on the trade-of between using numerous specific Requests for Production (RFPs) versus broader
composite categories (CCs). Conducted within a complex litigation case, their study reveals that
while more granular RFPs aim for precision, they can reduce reviewer speed and consistency, creating
ineficiencies in document categorization. Reviewers showed variability in assigning documents to
categories, suggesting that automated categorization may ofer a more reliable alternative. This research
underscores the need for balance in categorization strategies, as excessive specificity may hinder
consistent review outcomes.</p>
        <p>The authors in [19] propose an enhancement in systematic review protocols, advocating for a "spiral
approach" that leverages machine learning more efectively in staged review processes. Traditionally,
systematic reviews follow the PRISMA two-stage protocol, beginning with title/abstract screening before
progressing to full-text retrieval. However, the authors suggest that integrating full-text retrieval earlier
enables machine learning to operate on more comprehensive data sooner, enhancing the eficiency and
precision of reviews. They also recommend that machine learning classifiers in systematic reviews
favor logistic regression, with TF-IDF for feature extraction and probability-based query prioritization.
This approach aims to address the limitations of sequential filtering and optimize TAR workflows
by incorporating full-text screening earlier, thus maximizing the utility of machine learning without
increasing workload. The integration of a protocol that maintains contextualization while improving
eficiency aligns with the goal of optimizing TAR performance, particularly when large data collections
are involved.</p>
        <p>These studies highlight the nuances of implementing TAR protocols in complex legal environments,
where balancing recall, privacy, and consistency is critical to maintaining defensibility and eficiency in
document review.</p>
      </sec>
      <sec id="sec-2-6">
        <title>2.6. Comparison and Performance Analysis of TAR Tools</title>
        <p>In this section, we address the variability in performance across TAR tools, highlighting the role of
feedback mechanisms and dense retrieval models in improving screening prioritization for systematic
review automation.</p>
        <p>[20] underscores the challenge of achieving reliable recall and precision when transitioning from
paper-based to electronic document reviews. They propose that TAR methods should strive to meet the
hypothetical standard of a "reasonable reviewer," with recall and precision evaluated relative to this
benchmark. The authors note significant variance in recall and precision estimates across diferent
review teams, attributing discrepancies to low prevalence rates and the random ordering of documents.</p>
        <p>[21] investigates dense retrieval models, specifically BERT-based retrievers, for TAR screening
prioritization. Unlike traditional methods, this approach benefits from iterative, explicit relevance
feedback from reviewers without requiring frequent re-fine-tuning, thus improving eficiency. Their
results indicate that dense retrieval with feedback can match or exceed specialized prioritization methods
in efectiveness, ofering a more eficient alternative by eliminating the need for constant retraining.</p>
      </sec>
    </sec>
    <sec id="sec-3">
      <title>3. Conclusions</title>
      <p>In this survey, we have explored recent advancements and critical areas in TAR systems, particularly
focusing on methods for optimizing document screening in medical systematic reviews and eDiscovery.
Through an analysis of emerging technologies, including Large Language Models (LLMs), stopping rule
mechanisms, data-driven approaches, and robust evaluation metrics, we have outlined the multifaceted
nature of TAR research and development.</p>
      <p>Specifically, we reviewed the role of LLMs in Boolean query training and relevance screening, where
recent studies show the promise of these models in generating high-quality queries and accurately
ifltering abstracts. On the other hand, the research on stopping rules demonstrated the importance
of both reinforcement learning (RL) and heuristic methods in determining optimal points for halting
document review, which remains a critical eficiency factor in TAR workflows.</p>
      <p>We further explored the significance of evaluation metrics and reproducibility in TAR systems,
emphasizing metrics and defensible validation protocols that can uphold accuracy and reliability.
Lastly, we examined protocols for implementing TAR in legal contexts and conducted a comparative
performance analysis of popular TAR tools, revealing the role of feedback and dense retrieval models in
enhancing screening prioritization.</p>
      <p>The analysis has highlighted several directions for future research in this field. For example, while
LLMs have shown potential in query formation and relevance screening, future studies should explore
ways to refine these models with domain-specific knowledge bases. This would further improve
the precision and contextual relevance of document screening in specialized areas such as legal and
biomedical research. In addition, developing adaptive, context-sensitive stopping criteria will be crucial
for maximizing TAR eficiency without compromising accuracy. This might involve hybrid models that
combine heuristic transparency with RL adaptability, allowing more flexible application across diverse
TAR settings. Of course, the optimization of the models as well as the evaluation of the heuristics need
the creation of standardized, high-quality datasets tailored to TAR applications remains a critical need.
Openly accessible and annotated datasets would greatly facilitate model benchmarking, training, and
reproducibility, while also enabling fair performance comparisons across diferent TAR approaches.
Ensuring that TAR models perform consistently across diferent domains and use cases requires the
development of more granular evaluation metrics and reproducibility protocols. This includes creating
metrics that reflect both task-specific requirements and broader model reliability, as well as validation
techniques that can standardize the TAR evaluation process.
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