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  <front>
    <journal-meta>
      <journal-title-group>
        <journal-title>HC@AIxIA</journal-title>
      </journal-title-group>
      <issn pub-type="ppub">1613-0073</issn>
    </journal-meta>
    <article-meta>
      <title-group>
        <article-title>Assessing the Validity of a Functional Status Knowledge Graph in a Large-Scale Living Lab</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Mauro Dragoni</string-name>
          <email>dragoni@fbk.eu</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Gianluca Apriceno</string-name>
          <email>apriceno@fbk.eu</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Tania Bailoni</string-name>
          <email>tbailoni@fbk.eu</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Workshop</string-name>
        </contrib>
        <contrib contrib-type="editor">
          <string-name>Knowledge Graph, Digital Health, Large-scale Living Lab</string-name>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>Fondazione Bruno Kessler</institution>
          ,
          <addr-line>Via Sommarive 18, Povo, 38213</addr-line>
          ,
          <country country="IT">Italy</country>
        </aff>
      </contrib-group>
      <pub-date>
        <year>2024</year>
      </pub-date>
      <volume>3</volume>
      <fpage>25</fpage>
      <lpage>28</lpage>
      <abstract>
        <p>Functional Status Information describes physical and mental wellness at the whole-person level. Collecting and analyzing this information is critical to address the needs for caring for an aging global population, and to provide efective care for individuals with chronic conditions, multi-morbidity, and disability. Knowledge Graphs represent a suitable way for meaning in a complete and structured way all information related to people's Functional Status Information and reasoning over them to build tailored coaching solutions supporting them in daily life for conducting a healthy living. In this paper, we describe the integration of our Functional Status Knowledge Graph, namely FuS-KG, into a real-world application run within a large-scale living lab involving more than 4,000 people. We provide the road map of this experience including the challenges, the platform's architecture, the focus on the knowledge layer, and the evaluation and insights observed.</p>
      </abstract>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>1. Introduction</title>
      <p>There is a growing trend of developing virtual health and well-being assistants to support lifestyle and
disease management, partly due to the growing societal need for managing health and preventing illness.
To improve an individual’s situation, a change of behavior is typically necessary, which puts focus on how
a digital coach can act in collaboration with the individual to support the individual’s ambition to improve
their health through behavior change, e.g., by adhering to medical guidelines or treatment protocols,
increasing physical activity, changing nutrition habits, reducing stress or intake of toxic substances. As a
basis for deciding how to act, the digital coach may explore the Functional Status Information (FSI) of
monitored individuals.</p>
      <p>A necessary foundation for a medical and health-related system’s reasoning, decision-making, and
acting is (i) the medical knowledge that the digital coach utilizes, (ii) the theories and knowledge about
how humans form motivation and change behavior as well as manage physical, social, and psychological
barriers, and (iii) the FSI (data) about the individual as well as the individuals’ narrative about their
behavior change journey, information that needs to be treated following ethical guidelines and regulations.
Moreover, the realization of such systems relies on the integration of efective, eficient, and ethical
strategies for adapting behavior in a situation depending on the individual’s context, personal preferences,
and needs (e.g., displaying motivational messages that are tailored to each individual’s resources and
current situation).</p>
      <p>A proper representation of this information requires a strategy able to mitigate the diversity of the
information managed and a conceptual model enabling the exploitation of such information by preserving,
at the same time, the privacy aspects. Knowledge Graphs (KGs) are a valid way to provide an efective
representation of FSI and to connect such information with users’ records (e.g., electronic health records)
to enable the design of AI-based systems implementing the coaching paradigm for avoiding Functional
Status (FS) deterioration in target users.</p>
      <p>CEUR</p>
      <p>ceur-ws.org</p>
      <p>In this paper, we present the experience concerning the adoption into a real-world setting of a brand new
KG, namely FuS-KG, supporting the representation of FSI and its exploitation to manage the generation
of healthy recommendations for citizens.</p>
      <p>Our experience is split into the three major steps presented in the remainder of the paper and summarized
below. First, the construction of FuS-KG (Section 3), which represents the first original contribution
of this work. Second, the integration of FuS-KG into a real-world digital health platform (Section 4),
namely Salute+, is provided for completeness of understanding, but it must not be considered an original
contribution of this paper. Third, the validation of the FuS-KG-enhanced Salute+ platform within a
large-scale living lab involving more than 4,000 users within the Trentino territory (Section 6), which is
the second original contribution of this work demonstrating the efectiveness of the proposed solution.</p>
    </sec>
    <sec id="sec-2">
      <title>2. Related Work</title>
      <p>Understanding the FS of a person is a key step toward tailoring precise interventions and providing
services to improve an individual’s health status and maximize functional independence in daily activities.
However, managing health often poses diferent challenges, related to healthcare systems being unable
to provide adequate support to individuals with chronic illnesses or disabilities due to the scarcity of
resources. The National Committee on Vital and Health Statistics (NVHCS) states that understanding
the FS is necessary to achieve optimal health outcomes 1. The evaluation of the FS is characterized by
a clinician-patient interaction to get insights into patients’ lifestyles, together with standardized tests.
Nevertheless, these assessments provide merely a snapshot of an individual’s health status, while efective
behavior change for health improvements is a long-term process. Consequently, a gap exists between an
individual’s health objectives and the ‘‘infrequent’’ health assessments conducted in healthcare settings,
which may prevent the delivery of high-quality care. Therefore, frequent data collection is required to
bridge this gap and ensure continual support.</p>
      <p>
        Physicians and researchers have conducted a few studies on elderly people that led to the identification
of the risk factors able to detect those most susceptible to functional decline [
        <xref ref-type="bibr" rid="ref1 ref2 ref3">1, 2, 3</xref>
        ]. Nonetheless, FSI is
underutilized, limiting its potential impact [
        <xref ref-type="bibr" rid="ref4">4</xref>
        ].
      </p>
      <p>
        One of the reasons may be that many physicians do not fully recognize the significance of this
information [
        <xref ref-type="bibr" rid="ref5 ref6">5, 6, 7, 8</xref>
        ]. Indeed, even when informed about a patient’s health status, only a minority alter patient
management accordingly.
      </p>
      <p>
        Studies based on self-reports of functional performance and early decline show successful prediction
of actual performance and decline [9, 10]. However, researchers note these reports capture only a fraction
of the problems [
        <xref ref-type="bibr" rid="ref3">3</xref>
        ]. Consequently, there is a need for innovative methods to assess FS, including
nonintrusive approaches that evaluate the patient’s functional performance, in both normal and abnormal
conditions, without relying solely on physician-patient interaction. For example, in [11] sensor-based
systems can detect a decline in daily activities, thus facilitating tailored interventions. Given the increasing
elderly population, such systems are crucial for early detection and intervention to prevent functional
deterioration and reduce the decline of functional ability.
      </p>
      <p>FuS-KG enables the investigation of this research field aiming to facilitate the development of
AIpowered systems capable of helping individuals monitor their FS and prevent function decline. The
adoption of FuS-KG in real-world scenarios is strongly connected to the design of behavior change
solutions since, given the detection of declining FS, the knowledge modeled within FuS-KG can be
exploited to perform reasoning operations for discovering possible behavior change trajectory with the
aims of improving the overall FS of a person. Concerning this point, FuS-KG fills a gap in the
state-ofthe-art since, as described below, to the best of our knowledge, KGs covering the whole FS landscape
have not been proposed yet.</p>
      <p>An example of a recent collaborative efort to develop observable and replicable interventions for
influencing behavior and health can be found in the behavioral change techniques taxonomy outlined
by [12]. This taxonomy facilitates the consolidation of knowledge regarding behavior and behavior change,
promoting the sharing and reuse of useful sources of behavior knowledge. Additionally, we note that, as
far as we are aware, at present there is no publicly accessible conceptual classification that conceptualizes
barriers to behavior change.</p>
      <p>An important taxonomy to mention is the human behavior taxonomy developed by the World Health
Organization 2 (WHO) [13]. This taxonomy, rooted in the WHO’s expertise and the International
Classification of Functioning (ICF), Disability, and Health, provides detailed class definitions based heavily
on the U.S. National Cancer Institute (NCI) Thesaurus, as well as the Oxford English Dictionary [14].
Another important efort aimed at understanding human behavior is the Semantic Mining of Activity,
Social and Health Data (SMASH) [15]. This project focuses on predicting human behavior and providing
explanations for these predictions.</p>
      <p>The Health Behavior Change Ontology (HBCO) was developed for a project to establish automated
dialogues between a psychologist and a user to provide behavioral counseling [16]. While the HBCO
ontology has enhanced the connection between theoretical and practical aspects, there are limited practical
implementations available. In turn, there is currently a lack of specific strategies for deploying a reusable
behavior change ontology in practice.</p>
      <p>Since our conceptualization has to align with the individual undergoing behavioral change, it is
fundamental to explore ontologies specifically modeling users, encompassing their profiles, characteristics,
and sometimes their behavior. For example, the General User Model Ontology (GUMO) [17] (included
in our ontology), the User Navigation Ontology (UNO) [18] and the Ontology of Personal Information
Management (OntoPIM) [19].</p>
      <p>Moreover, to cover the domain of physical activity behavior, notable examples of behavior ontologies
related to physical activity or exercise are the Ontology of Physical Exercises 3 and the HeLiS ontology [20]</p>
      <p>Finally, the use of KGs in the design of AI-based systems providing coaching has been researched and
evaluated. [21] describes a knowledge-based solution implemented in a system providing personalized
healthy lifestyle recommendations to users which was applied and evaluated in a real-world scenario. The
article highlights the already mentioned lack of structured knowledge publicly available but also provides
evidence of the feasibility of the proposed solution in a real-world setting based both on performance
evaluation and eficacy.</p>
    </sec>
    <sec id="sec-3">
      <title>3. Building FuS-KG</title>
      <p>The development of FuS-KG addressed a list of requirements aiming to satisfy the need to provide a KG
able to describe the domain of FS as-is and to support the conceptualization of an interoperable digital
twin of people using applications exploiting FuS-KG. This way, FuS-KG enables the possibility to perform
reasoning operations on such a digital twin also for predictive purposes by simulating possible future
undesired behaviors and, in turn, by generating recommendations persuading the users to avoid them.</p>
      <p>As we discussed in Section 2, ontologies available in domains connected with wellness and healthy
lifestyle have been designed with diferent aims. For example, ontologies concerning the physical activity
domain are created with a focus on classifying data without connecting each activity with potential
problems or benefits associated with the whole FS of a user. Similarly, the same happened with ontologies
concerning foods. FuS-KG has been built with a focus on the connection between diferent dimensions
related to people’s health representing their complete FS. The development of our ontology has been
driven by the following requirements:</p>
      <p>Requirement 1 (REQ1). The KG must conceptualize the food domain at a fine-grained level. This
means that the whole knowledge chain from defining each nutrient to modeling complex recipes must be
supported.</p>
      <p>Requirement 2 (REQ2). The KG must provide a comprehensive list of activities that a person can
perform. For each activity, it must be provided the knowledge required to understand the efort necessary
2https://www.who.int/classifications/drafticfpracticalmanual.pdf
3https://bioportal.bioontology.org/ontologies/OPE/?p=summary
to complete the activity to enable the inference of how much of each food defined under REQ1 is necessary
to fulfill the activity.</p>
      <p>Requirement 3 (REQ3). The KG must include the model of the barriers that may afect a person and
how such barriers obstacle the fulfillment of specific activities, the consumption of specific foods, or, in
general, the following of specific guidelines.</p>
      <p>Requirement 4 (REQ4). The KG must support the modeling of multi-modal knowledge since a
MMKG may be exploited to better support users’ education tasks and enable knowledge injection tasks
into large foundational models. Hence, the KG must include a multi-modal knowledge representation,
e.g., images of recipes and videos of how to execute activities.</p>
      <p>Requirement 5 (REQ5). Knowledge modeled under the requirements REQ1, REQ2, REQ3, and REQ4
must be associated with knowledge and data gathered from users’ input. Hence, the KG must include the
appropriate set of concepts to enable the definition of a user model and to support the linking between
such a user model and the domain knowledge defined through the requirements mentioned above.</p>
      <p>Requirement 6 (REQ6). A KG usable for creating a behavior change solution requires a set of
guidelines driving the behavior change intervention. A reasoner can exploit such guidelines to detect
situations where a user is not adhering to them. To enable this feature the KG must define the conceptual
knowledge that: (i) enables the modeling of such guidelines; (ii) defines how they can be associated with
the domain knowledge covered by the KG; and, (iii) allows their linking with a user profile.</p>
      <p>Requirement 7 (REQ7). The requirements discussed above refer to the notion of time in diferent ways.
For example, the merge of REQ2 and REQ4 concerning the modeling of an activity and how to perform it,
requires the modeling of the diferent steps and their temporal order. Similarly, both requirements REQ5
and REQ6 need the notion of time associated with the knowledge gathered by the user and when users’
data should be checked, respectively. Hence, the KG must include temporal knowledge to support the
requirements above and enable temporal reasoning over the users’ collected knowledge.</p>
      <p>Requirement 8 (REQ8). Working with such diferent domains may lead to building a very large KG.
Hence, the KG must be designed with a modular structure to ease its management and maintenance.</p>
      <p>The process for building FuS-KG followed a combination of the Modular Ontology Modeling
(MOMo) [22] and the METHONTOLOGY [23] methodologies. The rationale behind applying them in
tandem is that in the first phase, we worked on the modularization aspect given the expected size of FuS-KG
and the purpose of easing the possible reuse of only parts of the knowledge modeled. Then, we moved to
the conceptualization of each module. The choice of METHONTOLOGY was driven by the necessity
of adopting a lifecycle split into well-defined steps. Moreover, the development of FuS-KG requires the
involvement of the experts in situ. Thus, the adoption of a methodology having a clear definition of
the tasks to perform was preferred. Other methodologies, like DILIGENT [24] and NeOn [25], were
considered before starting the construction of FuS-KG. However, the characteristics of such methodologies,
like the emphasis on decentralized engineering, did not fit well our scenario.</p>
      <p>The overall process involved four knowledge engineers and three domain experts from the Trentino
Healthcare Department. More precisely, three knowledge engineers and two domain experts participated
in the ontology modeling stages (hereafter, the modeling team). While, the remaining knowledge engineer
and domain expert were in charge of evaluating the ontology (hereafter, the evaluators).</p>
      <p>Due to limited space, we do not provide a detailed description of each phase, but we limit ourselves to
reporting the most relevant activities of the construction process.</p>
      <sec id="sec-3-1">
        <title>3.1. Modules Definition</title>
        <p>As mentioned above, the first step focused on the application of the MoMo methodology to define FuS-KG
modules. This step aims to address REQ8. This step was necessary since the amount of knowledge
created by starting from the selected unstructured sources was huge. Hence, to ease the maintenance
of FuS-KG, the split into a set of modules was a mandatory step. Figure 1 provides an overview of the
modules composing the current version of FuS-KG.</p>
        <p>The knowledge contained in each module is the following:</p>
        <p>• core: this module includes the upper level of FuS-KG, i.e., the set of abstract concepts defining the
main type of knowledge covered by FuS-KG.
• food: this modules imports the core module and it contains all the knowledge about the BasicFood,
ComposedFood, and Nutrient. As BasicFood, we mean those foods for which fine-grained nutritional
information is provided within the sources we adopted to build FuS-KG (e.g., Bread). Then, as
ComposedFood, we mean those foods that are aggregations of instances of BasicFood but for
which fine-grained nutritional information is available as well (e.s., Tomato Sauce). While Nutrient
represents the specific nutritional information associated with a BasicFood.
• recipes: this module imports the diseases and (indirectly) the food module since a Recipe is defined
as a group of BasicFood each with the associated quantity. This module includes a set of
submodules containing (i) the list of the recipes collected from the diferent sources (we created one
sub-module for each source); and, (ii) the alignments between the diferent sources (i.e., we preserve
the fact that a recipe may be defined within more than one of the sources we used).
• diseases: this module imports the food module and it models the association between each BasicFood
and nutritional-wise Disease. Each association is modeled through a DiseaseRiskLevel entity
associating to each pair BasicFood-Disease a risk level.
• activity: this module imports the core module and it includes the taxonomy of all activities covered
by FuS-KG together with the knowledge related to the efort required to fulfill each activity. The
efort is represented through the Metabolic Equivalent of Task (MET) coeficient and the calories
required to perform 1 minute of each activity for each kilogram of body weight.
• barrier: this module imports the core module and it contains the type of barriers defined within the</p>
        <p>SIS manual and how these barriers may afect the fulfillment of specific activities.
• multi-modal: this module imports the recipes and activity modules. The module contains, when
available within the adopted sources, the multi-modal knowledge associated with specific Recipe
and Activity. In particular, the current version of FuS-KG contains knowledge about image and
video modalities.
• temporal: this module imports the recipes and activity modules. Then, this module is split into
two sub-modules. The first one defines the temporal intervals that may be of interest to model
the guidelines (e.g., Day, Meal). While the second one contains the knowledge related to steps to
prepare a specific Recipe or perform a specific Activity.
• guidelines: this module imports the barrier and temporal modules. This module aims to model
behavioral guidelines that may be associated with users to support reasoning tasks about possible
recommendations related to the user data that can be collected [26].
• user: this module imports the guidelines module. This way, the user module may access the full
knowledge of FuS-KG to enable the storage of any type of data that can be collected in several ways
(e.g., sensors or mobile applications).</p>
      </sec>
      <sec id="sec-3-2">
        <title>3.2. Modules Conceptualization</title>
        <p>FuS-KG aims to provide a conceptualization with a high granularity level. For example, for each recipe
modeled within FuS-KG, we provided its composition to the micro-nutrient level. Thanks to this granularity
level, we favor the integration of FuS-KG into several solutions going from simple mobile applications to
expert systems.</p>
        <p>The acquisition of the knowledge necessary for building FuS-KG has been done in two steps: (i) the
discussion with domain experts for deciding how to model the core entities of FuS-KG (i.e., abstract classes
and properties); and, (ii) the acquisition, analysis, and processing of unstructured resources containing
information to include in FuS-KG.</p>
        <p>The first step consisted of defining the set of entities addressing the list of requirements described above.
Here, the modeling team started from the conceptual model built to create the HeLiS ontology [27] since
it provides the basic elements to start satisfying requirements REQ1, REQ2, REQ5, and REQ6. Then,
such a conceptual model has been extended with further entities defined by the modeling team to cover
the remaining requirements, i.e., REQ3, REQ4, and REQ7. This way, the final description of the core
FuS-KG conceptual model defines the barrier domain and it has been equipped with the capabilities of
accepting knowledge related to both multi-modal resources and temporal information about entities.</p>
        <p>The second step consisted of identifying the sources for building and populating FuS-KG. In particular,
such sources were related to the following domains: food, activity, and barriers. The HeLiS ontology has
been used as a starting point to build the T-Box of FuS-KG. Concerning the food domain, we imported
into the FuS-KG schema, the model of the recipes already defined within the HeLiS ontology, i.e., (i) the
archives of the Italian Minister of Agriculture 4 and the Italian Epidemiological department 5; and, (ii) the
Turconi’s atlas [28]. Then, we selected the following four (1 structured and 3 unstructured) further sources
concerning the food and nutrition domain: (i) the USDA database 6, enriching the lists of basic foods
and nutrients provided by the HeLiS ontology; (ii) the Recipe1M 7 dataset, which provides both images
and step-wise description of recipes; (iii) the Tasty 8 dataset, which provides descriptions and videos of
recipe preparations; and, (iv) the RecipeDb 9 dataset, which provides a comprehensive set of recipes still
missing in FuS-KG. During the acquisition of such information, we also worked on the alignment between
the INRAN and USDA models to have a common representation of basic foods and nutrients. This way, it
was possible to reconcile the diferent sources exploited to build FuS-KG.</p>
        <p>Concerning the activity domain, we started from the Compendium of Physical Activities 10 to create
the taxonomy of physical activities and model all information concerning the associated efort. Finally,
concerning the barrier domain, we relied on the Supported Intensity Scale (SIS) manual 11 that provided
all the knowledge necessary to model barriers used to measure the functional status of a person. Here,
we integrated object properties defining which barriers may afect the capability of fulfilling specific
activities.</p>
        <p>As a final step, we focused on the refinement of the conceptual model adopted within FuS-KG and the
definition of the ontology design patterns (ODP) [ 29] to adopt. From the ODP catalog 12, we adopted
several patterns, in particular: the logical patterns Tree and N-Ary Relation, the alignment pattern Class
Equivalence, and the content patterns Parameter, Time Interval, Action, Classification .
4http://nut.entecra.it/
5http://www.bda-ieo.it/
6https://fdc.nal.usda.gov/
7http://pic2recipe.csail.mit.edu/
8https://cvml.comp.nus.edu.sg/tasty/
9https://cosylab.iiitd.edu.in/recipedb/
10https://pacompendium.com/
11https://www.aaidd.org/sis
12http://ontologydesignpatterns.org/wiki/Community:ListPatterns</p>
        <p>Finally, the main metrics related to the content of FuS-KG are summarized to give an overview of
its size: 588 Concepts, 128 Object Properties, 49 Data Properties, 58 Annotation Properties, 1879205
Individuals, and 8668859 Axioms.</p>
      </sec>
    </sec>
    <sec id="sec-4">
      <title>4. Integration Into the Salute+ Platform</title>
      <p>FuS-KG has been integrated into the Salute+ platform to enable its usage. In this section, we provide
a brief description of how FuS-KG has been integrated and the role it plays. This part is reported for
completeness of the in-use experience described in this paper, but it is not an original contribution of
this work. The reader may refer to [26] for a more in-depth description of the general architecture of the
platform and about the message generation pipeline.</p>
      <p>The Salute+ platform is composed of the four layers shown in Figure 2. The Input Layer, is responsible
for storing events that trigger the platform activities and accounts for the system’s ability to sense the
context of interaction. These events are of two types: (i) data input, where data are sent from the Input
Layer to the Knowledge Layer, and (ii) context communication, where contextual information is sent from
the Input Layer to the Communication Layer that may exploit this information for communication purposes.
The Knowledge Layer encompasses the FuS-KG resource described in Section 3. The Communication
Layer exploits the output of the Knowledge Layer (i.e., reasoning operations) for choosing the language
strategies to include in the natural language-generated messages, and focuses on the tasks of selecting the
arguments to include in the message, to order them, and to choose the right wording for each argument.
More information is provided below, but a detailed description of this layer is out of the scope of this paper.
Finally, the Output Layer closes the loop by providing the generated message to users. It represents the
many devices that can receive the data produced by the Communication Layer and conveys the physical
feedback to users.</p>
      <p>FuS-KG is exploited for monitoring the functional status of a user through its integration into a
SPARQLbased reasoner. Such a reasoner is used for detecting undesired situations within users’ behaviors. When
inconsistencies between the data provided by a user and the associated guidelines are detected, the reasoner
generates an individual of type UndesiredEvent that is then exploited by the CommunicationLayer to
generate feedback to users. The reasoner activity can be triggered in two ways. Firstly, each time a new,
or updated, data package is provided by a user (or acquired by an IoT device), the reasoner processes the
new, or updated, information. Secondly, at the end of a specific timespan (e.g., the end of a day, or the end
of a week), the reasoner checks data concerning the behavior of each user included in the system in such a
timespan. In the latter case, the reasoner works on a collection of data labeled with a timestamp valid within
the considered timespan. The integrated reasoner relies on the architecture implemented in RDFpro [30].
RDFpro has been chosen for two main reasons. Firstly, the architecture of RDFpro allows the integration
of custom methods into reasoning operations (i) for performing mathematical calculations on users’ data
and (ii) for exploiting real-time information acquired from external sources without materializing them
within the knowledge repository. Secondly, as reported in [30], eficient analysis performed on RDFpro
demonstrated the suitability of this reasoner compared with other state-of-the-art reasoners in a real-time
scenario. In this work, RDFpro has been adapted and extended to better fit the needs of the proposed
solution. The extension consisted of the integration of new methods supporting the real-time stream
reasoning of sensor data. This way, we were able to support the real-time processing of users’ data more
eficiently.</p>
    </sec>
    <sec id="sec-5">
      <title>5. Large-scale Living Lab: The Salute+ Project</title>
      <p>As introduced in Section 1, this work is part of the Salute+ 13 project. The project is a set of innovative
interventions/initiatives aimed at ofering the general population and specific categories of subjects,
13https://trentinosalutedigitale.com/blog/portfolio/trentinosalute/
diferent functions to create a context favorable to healthy choices through concrete opportunities and tools
to counteract the risk factors for the onset of chronic diseases such as poor nutrition and a sedentary lifestyle.
This project is part of a set of citizen health promotion initiatives run by Trentino Salute 4.0 14. Within
this framework, we ran a territorial living lab that enrolled 4,274 citizens using the mobile application
integrated within the Salute+ platform for seven weeks.</p>
      <p>The enrollment of the users was voluntary and no incentives were adopted. Indeed, all the users were
already motivated to participate in the study. All involved users have been equipped with smart bands
that synchronize information about steps and physical activity data with our system. However, users were
asked to insert a report of performed activities also manually to validate the synchronized information.
Part of future work is to reduce the efort in the acquisition of physical activity information.</p>
      <p>This study represented the first large-scale living lab in Trentino concerning the adoption of
knowledgeequipped AI tools supporting health prevention. The Trentino Salute 4.0 aims at extending the adoption
of the Salute+ solution to at least 30,000 citizens of the Province of Trento before the end of 2024 and to
open the adoption of this platform at the Italian National level during the two years 2025-2026.</p>
      <p>For completeness, Table 1 shows the main demographic information concerning the citizens involved
in the evaluation proposed in this work. We want to highlight that in this living lab, all users presented a
healthy status since in this first pilot, we decided not to accept people afected by chronic or other diseases.</p>
      <p>Dimension
Gender
Age
Education
Type of Occupation</p>
      <p>Property
Male
Female
25-35
36-45
46-55
56-65
High-school or lower
University Degree
Sedentary
Active Indoor
Active Outdoor</p>
    </sec>
    <sec id="sec-6">
      <title>6. Evaluation</title>
      <p>In this Section, we report the evaluation activities we performed on the Salute+ solution during the
forty-nine days timespan of the large-scale living lab described in Section 5. The results observed from
the collected data are presented in Section 6.1. While Section 6.2 discusses the key lessons learned from
this experience.</p>
      <sec id="sec-6-1">
        <title>6.1. Results</title>
        <p>This user study consisted of providing a group of users with a mobile application we created based
on the services included in the Salute+ solution. In particular, we measure the efectiveness of the
recommendations generated through the use of FuS-KG and we compared them with the results we
reported in [26] where a non-randomized experiments setup [31] was conducted with a Control Group
received predefined canned text messages and an Intervention Group received messages created with the
same methodology adopted in the Salute+ by relying on the HeLiS ontology instead of FuS-KG.</p>
        <p>The sets of guidelines implemented in this living lab were the same as used in the baselines allowing a
fair comparison of the results:
• MEAL-Rules (related to single meals) that check the correct quantity of a specific food category
to be consumed in a single meal. Users were asked to insert 4 meals every day: breakfast, lunch,
snack, and dinner.
• DAY-Rules (related to a single day) that check the maximum (or minimum) quantity (or portion) of
a specific food category that can (or should) be daily consumed.
• WEEK-Rules (related to a single week) that check the maximum (or minimum) quantity (or portion)
of a specific food category that can (or should) be weekly consumed.</p>
        <p>Figures 4, 5, and 6 present the evolution of the average number of undesired events per user detected
concerning the MEAL-Rules, DAY-Rules, and WEEK-Rules sets, respectively. The green lines represent
the trends of the Control Group, the blue lines represent the trends of the Intervention Group received
recommendations generated by using the HeLiS ontology, and, finally, the red lines represent the trends
observed on the users who adopted the Salute+ solution.</p>
        <p>As mentioned above, MEAL-Rules are verified every time a user enters a meal within the system;
DAY-Rules are verified at the end of the day; while WEEK-Rules are verified at the end of each week. The
increasing gap between the green lines and the others demonstrates the positive impact of the
knowledgebased generated recommendations sent to users. We can observe how the average number of detected
undesired events for the MEAL-Rules is below 1.0 after the first 7 weeks of the project. We can also
appreciate how the recommendations generated by using FuS-KG led to a better drop of the detected
undesired events compared to the ones generated by using HeLiS. A positive result has been obtained
also for the DAY-Rules and the WEEK-Rules. However, we can observe how for the DAY-Rules the
blue and red lines remained close for the entire timespan and, even if the FuS-KG group obtained a
better drop, the improvement is not significant. This is a point of attention that triggered a more in-depth
analysis of the data by combining the results observed for the MEAL-Rules with the ones observed for
the DAY-Rules since it is expected that an improvement in the quality of single meals, an improvement
should be observed also for the entire day. Instead, the fact that MEAL-Rules are more focused on
food quantity and DAY-Rules are more focused on food categories highlighted how users found more
easy-to-follow guidelines about the amount of food to consume during a single meal instead of distributing
food categories appropriately during the entire day. This result will drive the analysis of how to refine the
recommendations associated with DAY-Rules.</p>
        <p>For completeness, we report in Table 2 the drop values of the observed undesired events at the beginning
and at the end of the 7-week timespan of the living lab.</p>
        <p>QB-Rules
DAY-Rules
WEEK-Rules</p>
        <p>FuS-KG Group
85.06%
63.48%
53.02%</p>
        <p>HeLiS Group
76.63%
62.18%
40.12%</p>
        <p>Control Group
50.00%
41.98%
6.68%</p>
      </sec>
      <sec id="sec-6-2">
        <title>6.2. Lessons Learned</title>
        <p>The integration of FuS-KG within the Salute+ platform and the large-scale living lab we ran, provided
interesting insights, summarized in the four major lessons learned reported below, that can drive future
enhancement of the overall solution.</p>
        <p>Reasoning efectiveness. The efectiveness of the reasoner was one of the most sensitive aspects of
our living lab given the unpredictability of the number of contemporary reasoning tasks that could be
launched. However, the work performed on the optimization of rules design and rules evaluation schedule
allowed us to maintain the time for each reasoning task below 6 seconds making the interaction with the
users acceptable for a real-time context. The rule analysis and optimization process was performed in two
steps. In the first one, we designed a few complex rules for covering all monitoring activities. On the one
hand, we were able to cover several constraints with one rule. But, on the other hand, the computational
time required for evaluating these rules was high. Hence, in the second one, we opted for splitting the
rules in more simpler ones and, at the same time, scheduling their evaluation depending on their timing
property. This strategy led to an improvement in the overall reasoning performance and allowed us to have
easier control of the overall reasoning process (exactness of the Violation instances, debugging operations,
etc.). In the scenario addressed by the current deployment of Salute+, reasoning operations are performed
on sets of triple describing only users’ specific events.</p>
        <p>User perception about personalization. The second lesson is related to the actual perception that the
users involved in our large-scale living lab had about the personalization capabilities of the proposed
solution. To this extent, we organized a focus group at the end of the living lab with a subset of the
users who participated in it. We decided on the size of 30 users for the focus group. The users were
selected based on their diferent levels of violation drops. This way, it was possible to interview users
registered a diferent levels of adherence to the guidelines. The aim was to collect qualitative feedback
about the personalization perception of the generated recommendation by asking the users when the
system succeeded and when it can be improved concerning the content of the recommendations. Besides
the generally positive feedback received, during the discussion, we discovered that several users perceived
the combination of some rules as very hard to follow and the Salute+ platform has been perceived as not
very efective in explaining appropriately why such rules should be followed. All users who reported
this issue agreed that the Salute+ system should be able to detect scenarios in which some of the rules
cannot be followed by users and to automatically the user profile accordingly. This suggestion will be
discussed with the domain experts to better understand, for instance, if a priority mechanism on rules can
be integrated to discriminate scenarios in which the Salute+ system should discard some UndesiredEvent
individuals.</p>
        <p>Abandon rate. Further considerations can be made about the abandon rate of the system, a too-pushy
notification system could have a high abandon rate. In our case, the percentage of the users who used
the Salute+ mobile application for the entire monitoring period (i.e., seven weeks) was 87% and no
complaints about the notifications were raised during the focus group. A common request to increase the
engagement of the application was the possibility of better exploiting the geographical information that
can be acquired through smartphone sensors. This information was considered relevant for motivating
people to change habits within some real-life situations, for example not to stop at a vendor machine
during a walk. Suggested examples of the exploitation of geographical information include the possibility
of sending alerts about close healthy nutrition shops, restaurants cooking recipes that are compliant with
users’ goals, sports events related to preferred users’ habits, etc. These suggestions will lead the next
version of the personalization component of Salute+ to improve the perception that the system is providing
enhanced real-time support to users.</p>
        <p>Long-term adoption. At the end of the large-scale living lab, a discussion about the long-term adoption
of the Salute+ was necessary with a focus on FuS-KG given the efort required to keep the KG updated and
the vision of making it a reference point for the research community. We discussed this aspect through the
analysis of three main perspectives: (i) the availability and reusability of FuS-KG; (ii) the sustainability
plan; and, (iii) the maintenance plan.</p>
        <p>Concerning availability and reusability, FuS-KG is licensed under the Creative Commons
AttributionNonCommercial-ShareAlike 4.0 15. It is available for download from the FuS-KG website 16 and,
addi15https://creativecommons.org/licenses/by-nc-sa/4.0/
16https://w3id.org/fuskg
tionally, we have created a GitHub repository 17 to ease version control and issue tracking of the resource.
The choice of publishing the KG open-source is to foster its adoption within the community enabling also
the collection of feedback about its conceptualization to refine it. Moreover, by increasing its adoption,
sustainability will benefit as well.</p>
        <p>Concerning sustainability, as mentioned in the previous section, the presented ontology is the result
of collaborative work between several experts in the context of the framework Trentino Salute 4.0. The
main goals of this framework are to ‘‘combine eforts of employers, employees, and society to improve
the mental and physical health and well-being of citizens’’, which is a long-term objective aligned with
the Sustainable Development Goal 3 (i.e., ‘‘Ensure healthy lives and promote well-being for all at all
ages’’) of the United Nations, and it aims at preventing the onset of chronic diseases related to an incorrect
lifestyle through organizational interventions directed to citizens. The overall sustainability plan for
the continuous update and expansion of the FuS-KG ontology is granted by this framework since it is
considered a strategic asset within the AI Strategy of the Trentino Local Government.</p>
        <p>Finally, concerning the maintenance perspective, we opted to create a collaborative environment on
GitHub enabling the research community to collaborate in refining and expanding FuS-KG. This way,
through the Issues facility all community members may open new discussions concerning specific aspects
related to FuS-KG ranging from integrating new information sources to suggesting novel modeling
patterns.</p>
      </sec>
    </sec>
    <sec id="sec-7">
      <title>7. Conclusions and Future Work</title>
      <p>In this paper, we presented the modeling pathway of FuS-KG and how it has been integrated into the Salute+
platform representing a real-world solution aiming to support the promotion of healthy lifestyles to citizens.
We discussed the role of FuS-KG within the Salute+ platform and we presented the results observed within
a large-scale living lab in the Trentino territory involving more the 4,200 users. Results demonstrated
the possibility of adopting the system in real-world scenarios, and the reported lessons learned provide
insights for future developments to improve overall eficiency, thus allowing the deployment of the Salute+
platform in more challenging environments.
[7] D. R. Calkins, L. V. Rubenstein, P. D. Cleary, A. R. Davies, A. M. Jette, A. Fink, J. Kosecof, R. T.</p>
      <p>Young, R. H. Brook, T. L. Delbanco, Functional disability screening of ambulatory patients, Journal
of General Internal Medicine 9 (1994) 590–592.
[8] E. J. Cassell, Doctoring: The nature of primary care medicine, Oxford University Press, USA, 2002.
[9] L. P. Fried, Y. Young, G. Rubin, K. Bandeen-Roche, W. I. C. R. Group, et al., Self-reported preclinical
disability identifies older women with early declines in performance and early disease, Journal of
clinical epidemiology 54 (2001) 889–901.
[10] B. J. Wakefield, J. E. Holman, Functional trajectories associated with hospitalization in older adults,</p>
      <p>Western Journal of Nursing Research 29 (2007) 161–177.
[11] G. L. Alexander, M. Rantz, M. Skubic, M. A. Aud, B. Wakefield, E. Florea, A. Paul,
Sensor systems for monitoring functional status in assisted living facility residents,
Research in Gerontological Nursing 1 (2008) 238–244. URL: https://journals.healio.
com/doi/abs/10.3928/19404921-20081001-01. doi:10.3928/19404921- 20081001- 01.
arXiv:https://journals.healio.com/doi/pdf/10.3928/19404921-20081001-01.
[12] S. Michie, R. N. Carey, M. Johnston, A. J. Rothman, M. de Bruin, M. P. Kelly, L. E. Connell, From
Theory-Inspired to Theory-Based Interventions: A Protocol for Developing and Testing a
Methodology for Linking Behaviour Change Techniques to Theoretical Mechanisms of Action, Annals
of Behavioral Medicine 52 (2017) 501–512. URL: https://doi.org/10.1007/s12160-016-9816-6.
doi:10.1007/s12160- 016- 9816- 6.
arXiv:https://academic.oup.com/abm/articlepdf/52/6/501/27619577/s12160-016-9816-6.pdf.
[13] K. R. T. Larsen, S. Michie, E. Hekler, B. Gibson, D. Spruijt-Metz, D. Ahern, H. Cole-Lewis, R. Ellis,
B. Hesse, R. Moser, J. C. Yi, Behavior change interventions: the potential of ontologies for advancing
science and practice, Journal of Behavioral Medicine 40 (2016) 6–22.
[14] J. Weisz, M. Y. Ng, S. Bearman, Odd couple? reenvisioning the relation between science and
practice in the dissemination-implementation era, Clinical Psychological Science 2 (2014) 58 – 74.
[15] N. Phan, D. Dou, H. Wang, D. Kil, B. Piniewski, Ontology-based deep learning for human behavior
prediction with explanations in health social networks, Information Sciences 384 (2017) 298–313.
URL: https://www.sciencedirect.com/science/article/pii/S0020025516306090. doi:https://doi.
org/10.1016/j.ins.2016.08.038.
[16] T. W. Bickmore, D. Schulman, C. L. Sidner, A reusable framework for health counseling dialogue
systems based on a behavioral medicine ontology, Journal of Biomedical Informatics 44 (2011)
183–197. URL: https://www.sciencedirect.com/science/article/pii/S1532046411000025. doi:https:
//doi.org/10.1016/j.jbi.2010.12.006.
[17] D. Heckmann, T. Schwartz, B. Brandherm, M. Schmitz, M. Wilamowitz-Moellendorf, Gumo - the
general user model ontology, 2005, pp. 428–432.
[18] P. Kikiras, V. Tsetsos, S. Hadjiefthymiades, Ontology-based user modeling for pedestrian navigation
systems, in: ECAI 2006 Workshop on Ubiquitous User Modeling (UbiqUM), Riva del Garda, 2006.
[19] A. Katifori, M. Golemati, C. Vassilakis, G. Lepouras, C. Halatsis, Creating an ontology for the user
profile: Method and applications, in: RCIS, 2007.
[20] M. Dragoni, T. Bailoni, R. Maimone, C. Eccher, Helis: An ontology for supporting healthy lifestyles,
in: International Semantic Web Conference (2), volume 11137 of Lecture Notes in Computer Science,
Springer, 2018, pp. 53–69.
[21] M. Dragoni, M. Rospocher, T. Bailoni, R. Maimone, C. Eccher, Semantic technologies for healthy
lifestyle monitoring, in: The Semantic Web – ISWC 2018: 17th International Semantic Web
Conference, Monterey, CA, USA, October 8–12, 2018, Proceedings, Part II, Springer-Verlag, Berlin,
Heidelberg, 2018, p. 307–324. URL: https://doi.org/10.1007/978-3-030-00668-6_19. doi:10.1007/
978- 3- 030- 00668- 6\_19.
[22] C. Shimizu, K. Hammar, P. Hitzler, Modular ontology modeling, Semantic Web 14 (2023) 459–489.</p>
      <p>URL: https://doi.org/10.3233/SW-222886. doi:10.3233/SW- 222886.
[23] M. Fernández-López, A. Gómez-Pérez, N. Juristo, Methontology: from ontological art towards
ontological engineering, in: Proc. Symposium on Ontological Engineering of AAAI, 1997.
[24] H. S. Pinto, S. Staab, C. Tempich, DILIGENT: towards a fine-grained methodology for distributed,
loosely-controlled and evolving engineering of ontologies, in: R. L. de Mántaras, L. Saitta (Eds.),
Proceedings of the 16th Eureopean Conference on Artificial Intelligence, ECAI’2004, including
Prestigious Applicants of Intelligent Systems, PAIS 2004, Valencia, Spain, August 22-27, 2004, IOS
Press, 2004, pp. 393–397.
[25] M. C. Suárez-Figueroa, NeOn methodology for building ontology networks: specification, scheduling
and reuse, Ph.D. thesis, Technical University of Madrid, 2012. URL: http://d-nb.info/1029370028.
[26] M. Dragoni, I. Donadello, C. Eccher, Explainable AI meets persuasiveness: Translating reasoning
results into behavioral change advice, Artif. Intell. Medicine 105 (2020) 101840. URL: https:
//doi.org/10.1016/j.artmed.2020.101840. doi:10.1016/J.ARTMED.2020.101840.
[27] M. Dragoni, T. Bailoni, R. Maimone, C. Eccher, Helis: An ontology for supporting healthy lifestyles,
in: D. Vrandecic, K. Bontcheva, M. C. Suárez-Figueroa, V. Presutti, I. Celino, M. Sabou, L. Kafee,
E. Simperl (Eds.), The Semantic Web - ISWC 2018 - 17th International Semantic Web Conference,
Monterey, CA, USA, October 8-12, 2018, Proceedings, Part II, volume 11137 of Lecture Notes in
Computer Science, Springer, 2018, pp. 53–69. URL: https://doi.org/10.1007/978-3-030-00668-6_4.
doi:10.1007/978- 3- 030- 00668- 6\_4.
[28] G. Turconi, C. Roggi, Atlante fotografico alimentare. Uno strumento per le indagini nutrizionali,</p>
      <p>EMSI, 2007.
[29] P. Hitzler, A. Gangemi, K. Janowicz, A. Krisnadhi, V. Presutti (Eds.), Ontology Engineering with
Ontology Design Patterns - Foundations and Applications, volume 25 of Studies on the Semantic
Web, IOS Press, 2016.
[30] F. Corcoglioniti, M. Rospocher, M. Mostarda, M. Amadori, Processing billions of RDF triples on a
single machine using streaming and sorting, in: ACM SAC, 2015, pp. 368–375.
[31] A. Harris, J. C. McGregor, E. Perencevich, J. Furuno, J. Zhu, D. E. Peterson, J. Finkelstein, Position
paper: The use and interpretation of quasi-experimental studies in medical informatics, Journal of
the American Medical Informatics Association : JAMIA 13-1 (2006) 16–23.</p>
    </sec>
  </body>
  <back>
    <ref-list>
      <ref id="ref1">
        <mixed-citation>
          [1]
          <string-name>
            <given-names>L. P.</given-names>
            <surname>Fried</surname>
          </string-name>
          ,
          <string-name>
            <given-names>K.</given-names>
            <surname>Bandeen-Roche</surname>
          </string-name>
          ,
          <string-name>
            <given-names>P.</given-names>
            <surname>Chaves</surname>
          </string-name>
          ,
          <string-name>
            <given-names>B. A.</given-names>
            <surname>Johnson</surname>
          </string-name>
          , et al.,
          <article-title>Preclinical mobility disability predicts incident mobility disability in older women</article-title>
          ,
          <source>Journals of Gerontology-Biological Sciences and Medical Sciences</source>
          <volume>55</volume>
          (
          <year>2000</year>
          )
          <article-title>M43</article-title>
          .
        </mixed-citation>
      </ref>
      <ref id="ref2">
        <mixed-citation>
          [2]
          <string-name>
            <given-names>G.</given-names>
            <surname>Onder</surname>
          </string-name>
          ,
          <string-name>
            <given-names>B. W.</given-names>
            <surname>Penninx</surname>
          </string-name>
          ,
          <string-name>
            <given-names>L.</given-names>
            <surname>Ferrucci</surname>
          </string-name>
          ,
          <string-name>
            <given-names>L. P.</given-names>
            <surname>Fried</surname>
          </string-name>
          ,
          <string-name>
            <given-names>J. M.</given-names>
            <surname>Guralnik</surname>
          </string-name>
          ,
          <string-name>
            <given-names>M.</given-names>
            <surname>Pahor</surname>
          </string-name>
          ,
          <article-title>Measures of physical performance and risk for progressive and catastrophic disability: results from the women's health and aging study</article-title>
          ,
          <source>The Journals of Gerontology Series A: Biological Sciences and Medical Sciences</source>
          <volume>60</volume>
          (
          <year>2005</year>
          )
          <fpage>74</fpage>
          -
          <lpage>79</lpage>
          .
        </mixed-citation>
      </ref>
      <ref id="ref3">
        <mixed-citation>
          [3]
          <string-name>
            <given-names>F. D.</given-names>
            <surname>Wolinsky</surname>
          </string-name>
          ,
          <string-name>
            <given-names>D. K.</given-names>
            <surname>Miller</surname>
          </string-name>
          ,
          <string-name>
            <given-names>E. M.</given-names>
            <surname>Andresen</surname>
          </string-name>
          ,
          <string-name>
            <given-names>T. K.</given-names>
            <surname>Malmstrom</surname>
          </string-name>
          ,
          <string-name>
            <given-names>J. P.</given-names>
            <surname>Miller</surname>
          </string-name>
          ,
          <article-title>Further evidence for the importance of subclinical functional limitation and subclinical disability assessment in gerontology and geriatrics</article-title>
          ,
          <source>The Journals of Gerontology Series B: Psychological Sciences and Social Sciences</source>
          <volume>60</volume>
          (
          <year>2005</year>
          )
          <fpage>S146</fpage>
          -
          <lpage>S151</lpage>
          .
        </mixed-citation>
      </ref>
      <ref id="ref4">
        <mixed-citation>
          [4]
          <string-name>
            <surname>I. LI</surname>
          </string-name>
          , G. MS,
          <article-title>Capturing and classifying functional status information in administrative databases</article-title>
          ,
          <source>Health Care Financ Rev</source>
          <volume>3</volume>
          (
          <year>2003</year>
          )
          <fpage>61</fpage>
          -
          <lpage>76</lpage>
          . URL: https://pubmed.ncbi.nlm.nih.gov/12894635/.
        </mixed-citation>
      </ref>
      <ref id="ref5">
        <mixed-citation>
          [5]
          <string-name>
            <given-names>E.</given-names>
            <surname>Nelson</surname>
          </string-name>
          ,
          <string-name>
            <given-names>B.</given-names>
            <surname>Conger</surname>
          </string-name>
          ,
          <string-name>
            <given-names>R.</given-names>
            <surname>Douglass</surname>
          </string-name>
          ,
          <string-name>
            <given-names>D.</given-names>
            <surname>Gephart</surname>
          </string-name>
          ,
          <string-name>
            <given-names>J.</given-names>
            <surname>Kirk</surname>
          </string-name>
          ,
          <string-name>
            <given-names>R.</given-names>
            <surname>Page</surname>
          </string-name>
          ,
          <string-name>
            <given-names>A.</given-names>
            <surname>Clark</surname>
          </string-name>
          ,
          <string-name>
            <given-names>K.</given-names>
            <surname>Johnson</surname>
          </string-name>
          ,
          <string-name>
            <given-names>K.</given-names>
            <surname>Stone</surname>
          </string-name>
          ,
          <string-name>
            <given-names>J.</given-names>
            <surname>Wasson</surname>
          </string-name>
          , et al.,
          <article-title>Functional health status levels of primary care patients</article-title>
          ,
          <source>Jama</source>
          <volume>249</volume>
          (
          <year>1983</year>
          )
          <fpage>3331</fpage>
          -
          <lpage>3338</lpage>
          .
        </mixed-citation>
      </ref>
      <ref id="ref6">
        <mixed-citation>
          [6]
          <string-name>
            <given-names>D. R.</given-names>
            <surname>Calkins</surname>
          </string-name>
          ,
          <string-name>
            <given-names>L. V.</given-names>
            <surname>Rubenstein</surname>
          </string-name>
          ,
          <string-name>
            <given-names>P. D.</given-names>
            <surname>Cleary</surname>
          </string-name>
          ,
          <string-name>
            <given-names>A. R.</given-names>
            <surname>Davies</surname>
          </string-name>
          ,
          <string-name>
            <given-names>A. M.</given-names>
            <surname>Jette</surname>
          </string-name>
          ,
          <string-name>
            <given-names>A.</given-names>
            <surname>Fink</surname>
          </string-name>
          ,
          <string-name>
            <given-names>J.</given-names>
            <surname>Kosecof</surname>
          </string-name>
          , R. T. Young,
          <string-name>
            <given-names>R. H.</given-names>
            <surname>Brook</surname>
          </string-name>
          ,
          <string-name>
            <given-names>T. L.</given-names>
            <surname>Delbanco</surname>
          </string-name>
          ,
          <article-title>Failure of physicians to recognize functional disability in ambulatory patients</article-title>
          ,
          <source>Annals of internal medicine 114</source>
          (
          <year>1991</year>
          )
          <fpage>451</fpage>
          -
          <lpage>454</lpage>
          .
        </mixed-citation>
      </ref>
    </ref-list>
  </back>
</article>