The ICyberPhys-2025 focuses on all technical and practical aspects of the latest research and results of international scientists and practitioners related to Intelligent Systems, Green Technologies, Smart City & Smart House, IoT-Systems, Computer & Cyberphysical Systems, Security and Protection of Computer & Cyberphysical Systems. This workshop provides opportunities to exchange new ideas, to establish business or research relations and to find global partners for future collaboration. I hope that the workshop results make a significant contribution to the development of intelligent and cyberphysical systems in Ukraine. 2nd International Workshop on Intelligent & CyberPhysical Systems (ICyberPhyS-2025) received 51 submissions from Ukraine and the world. All papers were evaluated by two or three reviewers. Based on the reviews, a rating of papers was compiled. Papers with a positive average scores were accepted for presentation at the Workshop. According to the decision of the International Program Committee, 21 papers were accepted for presentation at the workshop. So, final acceptance rate is 41%. We would like to thank the members of International Program Committee and Organizing Committee, and external reviewers for their excellent and tireless work. We sincerely thank everyone for a fruitful work and interesting presentations! We hope that the workshop results make a significant contribution to the development of intelligent information technologies, and information security systems in Ukraine and in the world.