A Secure Data Repository Integrating Huge Volumes of Digital Contents as a Semantic Web Norio Kobayashi1 , Yuko Makita1 , Eli Kaminuma1 , Shuji Kawaguchi1 , Yuko Yoshida1 , Yoshiki Mochizuki1 , Akihiro Matsushima1 , Manabu Ishii1 , Ryo Umetsu1 , Satomi Asano1 , Naohiko Heida1 , Tetsuya Sakurai2 , Takashi Kuromori2 , Kazuo Shinozaki2 , and Tetsuro Toyoda1 1 Bioinformatics And Systems Engineering division (BASE), RIKEN, JAPAN toyoda@base.riken.jp?? 2 Plant Sciences Center (PSC), RIKEN, JAPAN 1 Abstract Recent omics sciences are strongly supported by the advances in various detec- tion technologies, such as the next generations high-throughput sequencers, high- resolution imaging devices and remote-sensing technologies. The obtained data, the processed data and knowledge extracted from the data are huge, heterolo- gous, complex and interconnected, and preventing us from sharing or depositing all of the data to the public databases. We have developed a semantic-web-based data repository by using the Semantic Web Folders (SWF for short) technology which is able to share large-scale omics data, experimental raw data, images, sequences and analysed data within a closed community and to publish all or a part of the data from the repository. SWF is designed not only for the data pub- lishing infrastructure, but also as a collaboration tool that allows researchers to generate a database. More concretely, SWF is designed to achieve the following features: 1) implementing an ontology-based data structure including file folders which enables users to write and store various kind of omics data, 2) supporting various data input/output formats including standardized data formats, 3) im- plementing a data viewer/editor including a meta search engine over SWF data, and 4) providing a communication tool that allow users to collaborate with each other to edit their data. In the current implementation of SWF, we employ a 30 TB Network Attached Strage system that stores a file folder associated with a ontology term. Moreover, more than 100 database projects including public ontology data and RIKEN’s original and public databases have been integrated on SWF. SWF is available at http://database.riken.jp. ?? To whom correspondence should be addressed.