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    <article-meta>
      <title-group>
        <article-title>Using Semantic Wikis for Structured Argument in Medical Domain</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Adrian Groza</string-name>
          <email>adrian@cs-gw.utcluj.ro</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Radu Balaj</string-name>
          <email>radu.balaj@student.utcluj.ro</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>Technical University of Cluj-Napoca Department of Computer Science Baritiu</institution>
          <addr-line>28, RO-400391 Cluj-Napoca</addr-line>
          ,
          <country country="RO">Romania</country>
        </aff>
      </contrib-group>
      <abstract>
        <p>This research applies ideas from argumentation theory in the context of semantic wikis, aiming to provide support for structured-large scale argumentation between human agents. The implemented prototype is exemplified by modelling the MMR vaccine controversy.</p>
      </abstract>
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  <body>
    <sec id="sec-1">
      <title>Motivation</title>
      <p>
        At the moment, there is an escalate of the individuals awareness and
interest with respect to the drugs they consume, possible side effects,
or related symptoms, in the context of some health-related scandals
such as RotaShield vaccine in 1999, GlaxoSmithKline’s vaccine in 2010,
or the government policies against AH1N1 in 2010. In many cases,
forums, blogs, or wikis are the first source of information when one starts
searching for health services like: ”best pediatrics physician in
neighbourhood”, ”side effects of rotarix vaccine” or ”the need to vaccinate against
swine flu”. The main issues regard finding the relevant information and
trusting that information when shaping ones own opinions to support
justified decisions. We approach these challenges by applying the work
done in argumentation theory in the context of semantic wikis, aiming to
build large scale of structured health-related argument corpus. Our work
enacts the idea of argumentative web as envisaged in [
        <xref ref-type="bibr" rid="ref1">1</xref>
        ] by facilitating
the semantic annotation of arguments by a large mass of users acting as
a social machine [
        <xref ref-type="bibr" rid="ref2">2</xref>
        ].
      </p>
    </sec>
    <sec id="sec-2">
      <title>Argumentation in Semantic Wiki</title>
      <p>Argument representation. Argumentation schemes encapsulate
common patterns of human reasoning such as: argument from popular
opinion, argument from sign, argument from evidence, argument from
position to know, or argument from expert opinion (figure 1). Argumentation
schemes are defined by a set of premises Ai, a conclusion C, and a set
of critical questions CQi. When a CQ is conveyed the credibility of the
conclusion is decreased. CQs have the role to guide the argumentation
process by providing the parties with a subset from the most encountered
possible counter-arguments.</p>
      <p>A1 : E asserts that A is known to be true.</p>
      <p>A2 : E is an expert in domain D.</p>
      <p>C : A may (plausibly) be taken to be true.</p>
      <p>CQ1 : Expertise- How credible is expert E as an expert source?
CQ2 : Field- Is E an expert in the field that the assertion, A, is in?
CQ3 : Opinion- Does E’s testimony imply A?
CQ4 : Trustworthiness- Is E reliable?
CQ5 : Consistency- Is A consistent with the testimony of other experts?
CQ6 : Backup Evidence- Is A supported by evidence?
CQ1 : as eo(?a) ∧ hasSource(?a, ?s) ∧ hasDom(?a, ?d) ∧ isExpIn(?s, ?d) → o1(?a, 1)
CQ2 : as eo(?a) ∧ hasP rop(?a, ?p) ∧ hasDom(?a, ?d) ∧ isP artOf(?s, ?p) → o2(?a, 1)
CQ5 : as eo(?a) ∧ hasP rop(?a, ?p) ∧ Expert(?e) ∧ hasDom(?a, ?d) ∧ isExpIn(?e, ?d)
∧supportsP roposition(?e, ?p) → sqwrl : count(?e)
as eo(?a) ∧ hasP rop(?a, ?p) ∧ Expert(?e) ∧ hasDom(?a, ?d) ∧ isExpIn(?e, ?d)
∧nonsupportsP rop(?e, ?p) → sqwrl : count(?e)</p>
      <p>Argument reasoning. At the technical level, for the semantic annotation
of arguments we use the semantic templates of the Semantic Media Wiki
(SMW) framework. The related arguments are exported from SMW in
Protege, where the strength of the argument is computed in Jess based
on the conveyed critical questions, represented by SWRL rules (figure 2).
Here arg : o1(?a, 1) assigns to the objection o1 of the argument a, the
degree of support 1. In this case, the ontology is updated with the
information that the appeal to authority is still valid. After all the
objections are checked, a rule computes the average mean of all objections
(using mathematical built-ins such as swrlb:add ) and the data property
hasCredibility of an argument is set.</p>
      <p>The available domain knowledge from the imported ontologies can also
help the process of computing the strengths of the given argument.
Thus, the rule modelling CQ1 is further refined if the source is not
an expert in field d1, but in another field d2 from the same domain:
d1 ≡ P ediatrics M edicine and d2 ≡ N eurology M edicine. The set
of all expertise fields is represented as a graph G = {V, E}, where V =
{v|v = f ield of expertise} and E = {(u, v)|u, v = nodes ∧ v u}, with
the root node Lif eSciences. The closer to the leaf l to which the subject
of debate is associated with, the greater the credibility of the node
representing the expert’s field of expertise e. Formally: |path(root,l)∩path(root,e)| .
|path(root,l)|
This follows the principle: the larger the field, the weaker the credibility.
In order to estimate the strength of CQ5, one has to count how many
experts who have made a statement believe that MMR vaccine causes
autism, and how many support the opposite conclusion (figure 2).
Finally, the value of credibility can be assessed by dividing the number of
experts who disagree with the hypothesis and the total number of experts
who have made a statement about the issue.</p>
      <p>Querying the argument corpus. The proposed framework facilitates
searching based on the following criteria: i) search by scheme: ”Give only
the arguments from expert opinion for supporting the argument
antibiotics are not recommended for pregnant women; ii) search by wikipedia
metadata, in which specific wiki-related terms can be used to limit or
refine the searching domain, such as 1) user: ”Give all the arguments of
Dr. Oz user against eating meat, 2) data: ”List all the arguments posted
from yesterday against vaccinate against MMR, or 3) location: ”Give all
the arguments of the users from Europe against genetic modified food.
By exploiting domain knowledge like Germany Europe, the system is
able to include in the answer the users from Germany too.
3</p>
      <p>
        Running Scenario
Consider the debate regarding the topic of vaccination and whether it
can cause autism in children. The hypothesis is attacked by a
pediatrician who instantiates the argument from expert opinion pattern (see
figure 3). A different opinion is given by a mother who correlates the
MMR vaccine with autism, by filling the template for cause to effect
argumentation scheme.When creating the arguments, the disputants can
use standard terms and concepts provided by the imported ontologies in
SMW, capability provided by the Semantic Gardening extension. Here,
the cause field MMR vaccine is annotated with the concept ”VO 0000731”
defined in the Vaccine Ontology (www.violinet.org) by the subsumption
chain: V O 0000731 V O 0000641 V O 0000001 OBI 0000047
M aterialEntity IndependentContinuant Continuant Entity.
Semantic wikis are exploited within a medical context for collaborative
knowledge acquisition, annotation, and integration: WikiNeuron,
WikiHit, WikiProteins, BOWiki, LexWiki, or the Hesperian Online Digital
Library [
        <xref ref-type="bibr" rid="ref3">3</xref>
        ]. Our approach is in line with [
        <xref ref-type="bibr" rid="ref4">4</xref>
        ] which advocates the
advantages of semantic wikis to exploit structured information.
      </p>
      <p>
        Persuasive argumentation for consumer health care is analysed in [
        <xref ref-type="bibr" rid="ref5">5</xref>
        ] with
the help of argumentation schemes. By enhancing drug consumers with
the ability to annotate side effects might help the regulatory bodies or
4
pharmacology industry to identify problems with newly launched drugs.
One goal is to build large scale argumentation corpora for the health
care domain. Based on hierarchical argumentation frameworks, users can
navigate between medical arguments with different levels of technical
specificity, in order to understand the language and the reasoning chain.
Akcnowledgements
This work has been co-funded by the Sectorial Operational Programme
Human Resources Development 2007-2013 of the Romanian Ministry of
Labour, Family and Social Protection through the Financial Agreement
POSDRU/89/1.5/S/62557 and PNII-Idei 170 CNCSIS.
      </p>
    </sec>
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