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  <front>
    <journal-meta />
    <article-meta>
      <title-group>
        <article-title>Improved Navigated Spine Surgery Utilizing Augmented Reality Visualization</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Zein Salah</string-name>
          <email>zein.salah@ovgu.de</email>
          <xref ref-type="aff" rid="aff0">0</xref>
          <xref ref-type="aff" rid="aff3">3</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Bernhard Preim</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Erck Elolf</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Jo¨rg Franke</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
          <xref ref-type="aff" rid="aff2">2</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Georg Rose</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
          <xref ref-type="aff" rid="aff3">3</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>1Department of Simulation and Graphics, University of Magdeburg</institution>
        </aff>
        <aff id="aff1">
          <label>1</label>
          <institution>Department of Neuroradiology, University Hospital of Magdeburg</institution>
        </aff>
        <aff id="aff2">
          <label>2</label>
          <institution>Department of Orthopedic Surgery, University Hospital of Magdeburg</institution>
        </aff>
        <aff id="aff3">
          <label>3</label>
          <institution>Department of Telematics and Biomedical Engineering, University of Magdeburg</institution>
        </aff>
      </contrib-group>
      <fpage>319</fpage>
      <lpage>323</lpage>
      <abstract>
        <p>Image-guided surgical systems are increasingly becoming established tools for visual aid in several interventional procedures. In this paper, we introduce a prototypic add-on system for enhancing the intraoperative visualization within a navigated spine surgery utilizing an extended reality approach. In essence, operation-speci c important anatomical structures are segmented from preoperative patient data and superimposed on the video stream of the operation eld. In addition, slices of the anatomy data, as well as shape and depth information of targeted structures, like spinal nerves or herniated discs, can be blended, which allows for a better protection of risk anatomy and accurate identication of the structures under consideration, and thus raises the safety and accuracy factors of the intervention.</p>
      </abstract>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>-</title>
      <p>
        One of the challenging tasks in a surgeon’s life is to transfer the information
displayed in 2D diagnostic images to the 3D situation in the real world of the
patient’s anatomy. This challenge is mastered in a continuous learning process,
still with significant obstacles. In this regard, medical navigation systems help
physicians to establish correspondences between locations in an acquired
patient dataset and the patient’s physical body during navigated surgeries. This
is highly advantageous for surgeries in regions with high density of critical and
vital structures; like the brain, skull base, and spine. However, this requires the
surgeon to switch between the operation field, i.e. microscope or endoscope view,
and wall-mounted or computer displays. Introducing augmented reality
facilitates the transfer of the diagnostic imaging to the individual patient anatomy
in a straightforward fashion. In this context, some research works provided
enhanced endoscopic views that are paired with synthesized virtual renderings
generated from the same view, e.g. [
        <xref ref-type="bibr" rid="ref1">1</xref>
        ]. Other systems tried to modify the design
of operating binoculars [
        <xref ref-type="bibr" rid="ref2">2</xref>
        ] and microscopes [
        <xref ref-type="bibr" rid="ref3">3</xref>
        ] to allow for data augmentation.
Augmented reality has also been introduced as a training tool for surgical
procedures [
        <xref ref-type="bibr" rid="ref4 ref5">4, 5</xref>
        ].
      </p>
      <p>In this paper, we present a prototype for improving intraoperative
visualization by augmenting the video stream of the operation field with relevant patient
data from different diagnostic and intraoperative imaging modalities. This will
facilitate the identification of vital structures like blood vessels and nerves or
landmarks like bony structures. This would potentially make surgical
procedures safer and easier. In addition, the presented approach may serve as a
teaching tool for surgical procedures, since critical anatomical relations can be
identified and discussed before the actual procedure starts.
2</p>
    </sec>
    <sec id="sec-2">
      <title>Material and Methods</title>
      <p>
        In this section, we adapt and extend our intraoperative visualization method [
        <xref ref-type="bibr" rid="ref6">6</xref>
        ]
for the use in navigated spine surgery. We first describe the new prototype setup
and then present the visualization approach.
2.1
      </p>
      <sec id="sec-2-1">
        <title>Prototype Setup: Calibration, Tracking, and Registration</title>
        <p>For tracking, we implement a marker-based optical tracking server, which
continuously captures a video stream of the trackable region with a high
resolution camera (Logitech QuickCam Pro 9000; 1280x720 pixel at 30 fps). The
tracking camera has to be calibrated once, the same way as the tablet PC camera.
At each frame, the system searches for predefined markers and, for each detected
marker, computes its pose in the camera coordinate system. Pose information of
all detected markers are transmitted to the tablet PC using the VRPN (Virtual
Reality Peripheral Network) protocol over a WLAN connection. Technically,
this design allows for connecting to several commercial tracking systems.</p>
        <p>Prior to the operation, a one-time, fully-automatic hand-eye calibration step
is performed. In essence, the tablet PC camera is calibrated with respect to the
tracker using a common reference marker that is visible (only at the calibration
step) to both cameras. A second tracked marker is fixed to the tablet PC.
Following the chain of transformations, the transformation from the tablet PC
marker to its video camera is calculated as Tmc = Tcr:Tkr1:Tkm, where the
transformations are video-camera to reference, tracker to reference, and tracker
to tablet PC marker, respectively. The transformation Tmc remains valid as long
as the marker does not move with respect to the video camera. At operation
time, the patient is fixed with respect to the reference marker, which can then be
removed from the view field of the camera. Thereafter, the transformation Tcr
can be computed using Tcr = Tmc:Tkm1:Tkr. Since Tmc and Tkr are fixed from
the previous step, Tcr is only dependent on the tracking data of the marker.</p>
        <p>To register the patient/phantom with the scanned dataset (and hence with
the anatomical models reconstructed from it), the reference marker is attached to
a rectangular plastic board that is scanned with the patient. The corners of the
marker are interactively selected from the scanned dataset, and their absolute
positions are calculated, considering image spacing, and defined as registration
points. 3D positions of the corresponding points in the patient coordinate system
are precisely defined using the tracking system. The two sets of points are finally
registered adapting a paired-point rigid registration scheme, applying a least
square fitting approach.
2.2</p>
      </sec>
      <sec id="sec-2-2">
        <title>Extended Reality Visualization Module</title>
        <p>
          The rendering module, running on the tablet PC, continuously captures a video
stream and renders it as a background. At each frame, relevant virtual objects
are rendered/overlaid using a two-pass rendering algorithm that highlights
objects silhouettes for better shape perception. Several objects can be overlaid
according to the current operation conditions. These include 3D reconstructions
of segmented structures from the anatomy dataset. Additionally, tomographical
slices can be superimposed. For this purpose, we adapt an optimized slicing
algorithm [
          <xref ref-type="bibr" rid="ref7">7</xref>
          ] to compute tomographical slices at the desired position and
orientation. The generated slice image is then blended in the real scene with the
correct pose. Here, the dimension and spacing of the 3D dataset and the
generated cross section are considered to correctly adjust the physical proportion
with the patient and environment. For certain structures, e.g. tumors, an
enhanced visualization of shape and depth information can also be provided. This
is achieved by extracting the planar contours of the tumor at successive depths
perpendicularly to the viewing direction. Depth information is conveyed via
depth cueing by defining the transparency of a contour as a linear function of
its depth.
        </p>
        <p>In minimally-invasive endoscopic or microscope-based spine surgery,
augmentation should be performed on the video stream of the endoscope/microcope
camera. However, this requires tracking these devices and a more complicated
calibration of their cameras.
3</p>
      </sec>
    </sec>
    <sec id="sec-3">
      <title>Results</title>
      <p>The software modules have been implemented with C++, OpenGL, VTK, and
Qt. For our current implementation, we relied on marker-based tracking
provided by the ARToolkit, which allows for multiple-marker tracking in real time.
However, due to the inaccurate calibration, we calibrate camera parameters
using MATLAB, as stated in Section 2.1. As a result, the new calibration was
significantly more accurate regarding marker detection and pose estimation.</p>
      <p>For our simulated OP scenario, a phantom model of the upper body is
scanned with the mounted reference marker. After extrinsic calibration of the
video camera, the phantom model is registered to the scanned data, using the
corners of the reference marker as the set of correspondence point pairs. From
a co-registered patient dataset, three vertebrae, inter-vertebral discs, and the
spinal canal are segmented and 3D models are reconstructed. Finally, the
visualization module starts video stream augmentation.</p>
      <p>The upper-left part of Figure 1 depicts a snapshot of the GUI of the
visualization module in a simulated spine surgery scenario. Figure 2 (left) shows a left
posterior oblique (LPO) view, with augmented models of the lumbar vertebrae
L2-L4 (cyan), inter-vertebral discs (green), and spinal canal (pink). Objects
silhouettes are slightly highlighted for enhanced shape perception. In Figure 2
(right), a side view with an additional transparent overlay of a tomographical
slice from the patient data is shown. The slicing algorithm allows for on-the-fly
computation and rendering of slices at a near real-time rate.
4</p>
    </sec>
    <sec id="sec-4">
      <title>Discussion</title>
      <p>A prototypic tablet PC based add-on for enhancing intra-operative visualization
has been introduced, with the focus on spine surgeries. The hardware setup and
functional components of the prototype have been depicted. We aim at raising
the safety and accuracy factors of the intervention by superimposing relevant
operation-specific anatomical structures on the video stream of the operation
field, which obviously allows for the protection of risk structures like spinal
nerves, blood vessels, and the spinal canal. In addition, targeted structures
like tumors or herniated discs are better localized and information about the
shape and extend of such structures can be conveyed at different depth levels.
From surgical point of view, we have received positive feedback regarding the
relevance and applicability of the presented approach. Our future work will
focus on transferring the prototype for application in real operation suits and
evaluating the applicability of the concept to other surgery scenarios.
Acknowledgement. This work is funded by the German Ministry of Education
and Science (BMBF) within the ViERforES project (No. 01IM08003C).</p>
    </sec>
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