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  <front>
    <journal-meta />
    <article-meta>
      <title-group>
        <article-title>for Surgical Planning</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Lucio T. De Paolis</string-name>
          <email>lucio.depaolis@unisalento.it</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Giovanni Aloisio Dept. of Innovation Engineering</string-name>
          <email>giovanni.aloisio@unisalento.it</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>Salento University Lecce</institution>
          ,
          <country country="IT">ITALY</country>
        </aff>
      </contrib-group>
      <fpage>65</fpage>
      <lpage>68</lpage>
      <abstract>
        <p>Modern technologies give a great support to the minimally invasive surgical procedures through medical image processing and visualization, 3D organ's reconstruction and intra-operative surgical guidance. The practice of Minimally Invasive Surgery is becoming more and more widespread and is being adopted as an alternative to the classical procedure. This technique presents some limitations for surgeons. In particular, the lack of depth in perception and the difficulty in estimating the distance of the specific structures in laparoscopic surgery can impose limits to delicate dissection or suturing. The presence of new systems for the pre-operative planning can be very useful to the surgeon. In this paper we present a visualization and interaction system that allows surgeon to visualize the 3D model of the patient's organs built from the CT images. Different visualization modalities are available according to the surgeon needs in laparoscopy and an Augmented Reality application permits the choice of the best insertion points of the trocars on the 3D virtual model and the visualization of these points on the real patient's body. Two case studies have been considered. The system can be used as support for the diagnosis, for the surgical preoperative planning and also as visual support during the surgical procedure.</p>
      </abstract>
      <kwd-group>
        <kwd>eol&gt;User interface</kwd>
        <kwd>image-guided surgery</kwd>
        <kwd>Augmented Reality</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>-</title>
      <p>Minimally Invasive Surgery (MIS) has become very
important and the researches in this field are ever more
widely accepted because these surgical techniques provide
surgeons with less invasive means of reaching the patient’s
internal anatomy and allow entire procedures to be
performed with only minimal trauma to the patients. As a
promising technique, the practice of MIS is becoming more
and more widespread and is being adopted as an alternative
to the classical procedures.</p>
      <p>The diseased area is reached by means of small incisions on
the body; specific instruments and a camera are inserted
through these ports and what happens inside the body is
shown in a monitor. The surgeon does not have a direct
vision of the organs and so he is guided by the camera
images. This surgical approach is very different from the
open surgery where the organs can be fully visualized and
handled.</p>
      <p>The advantages of using this surgical method are evident in
the patient because the trauma is reduced, the postoperative
recovery is almost always faster and the scarring is
reduced. Despite the improvement in outcomes, these
techniques show their limitations for the surgeons. In
particular, the lack of the perception of the depth and the
difficulty in estimating the distances of the specific organs
in laparoscopic surgery can impose some limits on delicate
dissection or suturing.</p>
      <p>Anyway, the overall risk of complications is of 8.0% in
laparoscopy versus 15.2% in laparotomy. Among these,
more than 50% of laparoscopic complications occur during
the initial entry into the abdomen.</p>
      <p>
        The modern medical imaging acquisition associated to the
medical image processing could lead to an improvement in
patient care by guiding the surgeons. The medical image
processing allows detecting and identifying anatomical and
pathological structures and building 3D models of the
patient’s organs that could be used to guide the surgical
procedures. Many research teams have dealt with the task
of segmentation and have developed techniques that allow
automatic or interactive extraction of the patient’s organ
models from CT-scan or MRI [
        <xref ref-type="bibr" rid="ref1">1</xref>
        ], [
        <xref ref-type="bibr" rid="ref2">2</xref>
        ].
      </p>
      <p>
        The Augmented Reality (AR) technology can provide the
advantage of a direct visualization in open surgery also in
minimally invasive surgery and can increase the physician's
view of his/her surroundings with information gathered
from patient medical images [
        <xref ref-type="bibr" rid="ref3">3</xref>
        ]. In general, AR technology
in minimally invasive surgery may be used for training
purposes, pre-operative planning and advanced
visualization during the real procedure. In surgery,
Augmented Reality technology makes possible to overlay
virtual medical images on the patient, allowing surgeons to
have a sort of “X-ray" vision of the body and providing
them with a view of the patient’s internal organs [
        <xref ref-type="bibr" rid="ref4">4</xref>
        ].
Motivated by the benefits that MIS can bring to patients,
many research groups are now focusing on the
development of systems in order to assist the surgeons
during the surgical procedures and have developed
solutions to support the preoperative surgical plannings and
the intra-operative surgical procedures.
      </p>
      <p>
        Samset et al. [
        <xref ref-type="bibr" rid="ref5">5</xref>
        ] present tools based on novel concepts in
visualization, robotics and haptics providing tailored
solutions for a range of clinical applications. Examples of
radio-frequency ablation of liver tumors, laparoscopic liver
surgery and minimally invasive cardiac surgery will be
presented.
      </p>
      <p>
        Bichlmeier et al. [
        <xref ref-type="bibr" rid="ref6">6</xref>
        ] focus on the problem of misleading
perception of depth and spatial layout in medical AR and
present a new method for medical in-situ visualization that
allows improved perception of 3D medical imaging data
and navigated surgical instruments relative to the patient’s
anatomy. They describe a method for integrating surgical
tools into the medical AR scene in order to improve
navigation.
      </p>
      <p>
        Navab et al. [
        <xref ref-type="bibr" rid="ref7">7</xref>
        ] introduce an interaction and 3D
visualization paradigm that presents a new solution for
using 3D virtual data in many AR medical applications.
They introduce the concept of a laparoscopic virtual mirror:
a virtual reflection plane within the live laparoscopic video,
that allows visualizing a reflected side view of the organ
and its interior. A clinical evaluation investigating the
perceptive advantage of a virtual mirror integrated into a
laparoscopic AR scenario has been carried out.
      </p>
      <p>
        De Paolis et al. [
        <xref ref-type="bibr" rid="ref8">8</xref>
        ] present an Augmented Reality system
that can guide the surgeon in the operating phase in order to
prevent erroneous disruption of some organs during
surgical procedures. The distance information is provided
to the surgeon and an informative box is shown in the
screen in order to visualize the distance between the
surgical instrument and the organ concerned.
      </p>
      <p>In this paper we present an advanced platform for the
visualization and the interaction with the 3D patient models
of the organs built from CT images.</p>
      <p>The developed application allows the surgeon to choose the
points for the insertion of the trocars on the virtual model,
to simulate the insertion of the surgical tools in order to
verify the correctness of the insertion sites and to overlap
the chosen entry points on the real patient body using the
Augmented Reality technology.</p>
      <p>The system could be used as support for a more accurate
diagnosis, in the surgical preoperative planning and also for
an image-guided surgery.</p>
      <p>THE CASE STUDIES
In MIS the use of the registered images of the patient is a
prerequisite both for the pre-operative planning and the
guidance during the operation. From the medical image of a
patient (MRI or CT), an efficient 3D reconstruction of his
anatomy can be provided in order to improve the standard
slice view; colors associated to the different organs replace
the grey levels in the medical images.</p>
      <p>
        In our case study the 3D models of the patient’s organs
have been reconstructed using segmentation and
classification algorithms provided by ITK-SNAP [
        <xref ref-type="bibr" rid="ref9">9</xref>
        ].
We processed two different case studies; the slice thickness
equal to 3 mm has caused some aliasing effects on the
reconstructed 3D models that could lead to inaccuracies.
Therefore we have paid special attention to the smoothing
of the reconstructed models in order to maintain a good
correspondence with the real organs.
      </p>
      <p>The first case study, shown in Figure 1, is a two-year-old
child with a benign tumor of the right kidney.</p>
      <p>The second case study, shown in Figure 2, is a
twelve-yearold child with a tumor of the peripheral nervous system
(ganglioneuroma).
THE USER INTERFACE
The developed application is supplied with a specific user
interface that allows the user to take advantage of the
feature offered by the software. The application is provided
of 4 sections with the aim to provide support to the
surgeons in the different steps of the surgical procedure
such as the study of the case, the diagnosis, the
preoperative planning, the choice of the trocar entry points and
the simulation of the surgical instruments interaction.
Starting from the models of the patient’s organs, the
surgeon can notice some data about the patient, collect
information about the pathology and the diagnosis, choose
the most appropriate positions for the trocar insertion and
overlap these points on the patient’s body using the
Augmented Reality technology.
In this way it is possible to use this platform for the
preoperative surgical planning and during the real surgical
procedure too. In addition, it could be used in order to
describe the pathology, the surgical procedure and the
associated risks to the child’s parents, with the aim of
obtaining informed consent for the surgical procedure.
In the developed application, all the patient’s information
(personal details, diseases, specific pathologies, diagnosis,
medical images, 3D models of the organs, notes of the
surgeon, etc.) are structured in a XML file associated to
each patient.</p>
      <p>A specific section for the pre-operative planning includes
the visualization of the virtual organs and the physician can
get some measurements of organ or pathology sizes and
some distances; this section is shown in Figure 3. By means
of a detailed view of the 3D model, the surgeon can choose
the trocar entry points and check if, with this choice, the
organs involved in the surgical procedure can be reached
and the procedure can be carried out in the best way.
THE AUGMENTED REALITY SECTION
Sometimes, using the standard insertion points for the
surgical tools, also a simple surgical procedure can be very
difficult due to the specific anatomy of the different
patients. The surgeon can have some difficulties to reach
the specific organ or the interaction of the surgical tools can
be very hard. In this case the surgeon has to choose another
insertion point in order to be able to carry out the surgical
procedure in the most suitable way.</p>
      <p>Our aim is to avoid the occurrence of this situation during
the real surgical procedure using the visual information
provided by means of the 3D models of the patient’s
anatomy.</p>
      <p>In the developed application, in order to verify if the
chosen insertion points allow properly reaching the specific
organ interested by the surgical operation and permitting to
carry out the procedure in a correct way, it is also possible
to simulate the interaction of the surgical instruments. We
also use the AR technology in order to visualize on the
patient’s body the precise location of the selected points on
the virtual model of the patient.</p>
      <p>
        For the augmented visualization, in order to have a correct
and accurate overlapping of the virtual organs on the real
ones, a registration phase is carried out; this phase is based
on fiducial points. Using the augmented visualization, the
chosen entry points for the trocars can be visualized on the
patient’s body in order to support the physician in the real
trocar insertion phase.
In our application, we have used the Polaris Vicra optical
tracker of NDI [
        <xref ref-type="bibr" rid="ref10">10</xref>
        ]; the system consists of 2 IR cameras
and uses a position sensor to detect retro-reflective markers
affixed to the surgical tools or located on the patient’s
body; based on the information received from these
markers, the sensor is able to determine position and
orientation of tools within a specific measurement volume.
The tracker can calculate the current position of the tool in
the space with an accuracy of 0.2 mm and 0.1 tenth of a
degree.
      </p>
      <p>Usually the tracking technology is already in the operating
rooms and provides an important help to enhance the
performance during the real surgical procedures.
CONCLUSIONS AND FUTURE WORK
The developed application offers a tool to visualize the 3D
reconstructions of the patient’s organs, obtained by
segmentation of a CT slices, and to simulate the placement
of the trocars in order to verify the correctness of the
insertion sites. A complete user interface allows a simple
and efficient utilization of the developed application.
Furthermore the system retains patient and pathology
information that the surgeon can insert and includes an
Augmented Reality module that supports the placement of
the trocars on the patient’s body during the real surgery
procedure. An accurate integration of the virtual organs in
the real scene is obtained by means of an appropriate
registration phase based on fiducial points.</p>
      <p>The developed platform can support the physician in the
diagnosis steps and in the pre-operative planning when a
laparoscopic approach will be followed. This support could
also lead to a better communication between physicians and
patient’s parents in order to obtain their informed consent.
The platform has been tested on study cases already
operated by the surgeon; the future work will be the
validation of the developed application on a new study case
by following all the steps from the diagnosis to the
preoperative planning and to the first phase of the real surgical
procedure.</p>
      <p>The building of a new Augmented Reality system that
could also help the surgeon during the other phases of the
surgical procedure has been planned as future work.
ACKNOWLEDGMENTS
This work is part of ARPED Project (Augmented Reality</p>
      <p>Application in Paediatric Minimally Invasive Surgery)
funded by the Fondazione Cassa di Risparmio di Puglia,
Italy. The aim of the ARPED Project is the design and
development of an AR system that can support the surgeon
through the visualization of anatomical structures during a
laparoscopic surgical procedure.</p>
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