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  <front>
    <journal-meta />
    <article-meta>
      <title-group>
        <article-title>The Social Semantic Subweb of Virtual Patient Support Groups</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Harold Boley</string-name>
          <xref ref-type="aff" rid="aff2">2</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Omair Sha q</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Derek Smith</string-name>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Taylor Osmun</string-name>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>Department of Computer Science, University of Calgary Calgary</institution>
          ,
          <addr-line>AB</addr-line>
          ,
          <country country="CA">Canada</country>
          ,
          <addr-line>moshafiq AT ucalgary.ca</addr-line>
        </aff>
        <aff id="aff1">
          <label>1</label>
          <institution>Faculty of Computer Science, University of New Brunswick Fredericton</institution>
          ,
          <addr-line>NB</addr-line>
          ,
          <country country="CA">Canada</country>
        </aff>
        <aff id="aff2">
          <label>2</label>
          <institution>Institute for Information Technology, National Research Council Canada Fredericton, NB, Canada</institution>
          ,
          <addr-line>harold.boley AT nrc.gc.ca</addr-line>
        </aff>
      </contrib-group>
      <abstract>
        <p>Patients increasingly interact in support groups, which provide shared information and experiences about diseases, treatments, etc. Much of this interaction is mediated by the Social Web, allowing worldwide reach but lacking in semantic precision. We present an online prototype, PatientSupporter, to create a Social Semantic Subweb that will facilitate high-precision networking between patients based on ontologies and rules. PatientSupporter is an instantiation of Rule Responder that permits each patient to query other patients' pro les for nding or initiating a matching group. Rule Responder's External Agent (EA) is a Web-based patient-organization interface that passes queries to the Organizational Agent (OA). The OA represents the shared knowledge of the virtual patient organization, delegates queries to relevant Personal Agents (PAs) via a responsibility ontology, and passes checked PA answers back to the EA. Each PA represents the medical subarea of primary interest to an associated patient group. The PA assists its patients by advertising their interest pro les, employing rules about diseases and treatments as well as interaction constraints such as time, location, age range, gender, and number of participants. Pro les can be distributed across di erent rule engines using di erent rule languages (e.g., Prolog and N3), where rules, queries, and answers are interchanged via translation to and from RuleML/XML. We discuss the implementation of PatientSupporter in a use case of sports injuries structured by a part-whole ontology of a ected body parts.</p>
      </abstract>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>-</title>
      <p>
        Social Web (Web 2.0) techniques have been explored in recent years for
applications in healthcare [
        <xref ref-type="bibr" rid="ref13 ref14">14, 13</xref>
        ]. Web 2.0 portals such as PatientsLikeMe1 and (part
of) samestory2 have been developed to help patients to network with other,
geographically distributed patients having similar ailments to discuss and exchange
      </p>
    </sec>
    <sec id="sec-2">
      <title>1 http://www.patientslikeme.com/ 2 http://www.same-story.com/sante-maladies/</title>
      <p>information and experiences. Successful `Patient 2.0' portals typically have good
recall when searching for other patients but lack in precision.</p>
      <p>Semantic techniques increase this networking precision, leading to the
following Social Semantic Web (Web 3.0) approach to patient portals. We
introduce ontologies and rules for organizing patients { here, with sports injuries {
into virtual support groups around classes of an ontology of injuries { here, a
commonsense partonomy for localizing sports injuries. Of course, this can only
complement the diagnosis and therapy of diseases by medical experts { it re ects
new patients' use of commonsense knowledge, rather than expert knowledge, to
nd similar patients as well as relevant literature and medical professionals.</p>
      <p>
        Our initial online prototype, PatientSupporter3, is designed to start the
Social Semantic Subweb for patients by demonstrating how patients with a
sports injury could be helped to nd or initiate a virtual support group about
that injury. Patients in an online PatientSupporter virtual organization create
their semantic pro le referring to classes in a disease ontology { here a partonomy
of body parts a ected by sports injuries. This body partonomy allows patients to
base the description of their injuries on a subPartOf hierarchy leading to a ected
body parts, which is implemented as a corresponding subClassOf taxonomy
of injury classes for those body parts. Pro les contain rules about body-part
diseases and treatments as well as interaction constraints such as time,
location, age range, gender, and number of participants. A patient can pose queries
against the semantic pro les of other patients in his or her virtual
organization to nd or initiate a matching group. PatientSupporter is built upon
Rule Responder [
        <xref ref-type="bibr" rid="ref19 ref9">19, 9</xref>
        ], which has also been used, e.g., in the related Social
Semantic Web instantiation WellnessRules [
        <xref ref-type="bibr" rid="ref8">8</xref>
        ] and in SymposiumPlanner [
        <xref ref-type="bibr" rid="ref12">12</xref>
        ].
      </p>
      <p>
        PatientSupporter allows patients to have their pro les expressed in either
Pure Prolog [
        <xref ref-type="bibr" rid="ref20">20</xref>
        ] (Horn logic rules) or N3 [
        <xref ref-type="bibr" rid="ref2">2</xref>
        ] (graph production rules). Providing
these quite di erent rule language paradigms permits virtual organizations or
individual patients to base their PatientSupporter use on the paradigm that
best suits them. Rule Responder handles the interoperation between di erent
rule languages of patients through translators to and from RuleML/XML as the
interchange format [
        <xref ref-type="bibr" rid="ref10">10</xref>
        ].
      </p>
      <p>As an example, let us consider a patient with nickname Paul, who has injured
part of his left leg during a rugby game. He has questions about his lesion
and precautions for recovery, which others with similar lesions may be able to
answer or help with. Since he lives in a small town where he knows no one else
with such an injury he looks for online support.4 Using PatientSupporter, Paul
poses a query through the External Agent (EA), focusing on leg lesions. The
EA submits the query to the Organizational Agent (OA), which delegates it to
the Personal Agent (PA) of the leg-injury group, and checks the answers from
the pro les (local knowledge bases) of its participating patients. When the OA
returns many answers to the EA, Paul discovers that his query was too broad.</p>
    </sec>
    <sec id="sec-3">
      <title>3 http://ruleml.org/PatientSupporter/</title>
      <p>4 Other reasons for seeking support in a virtual rather than real group may include
increased anonymity (via nicknames) and avoiding contagiousness (e.g., u).
Paul, who actually hurt his left knee, thus proceeds downward the partonomy
by querying PatientSupporter just for patients with knee lesions. Since no
kneeinjury PA exists, the OA again delegates it to the more general leg-injury PA.
But within this PA's group only the knee-injury participants are eligible, hence
the answers returned are less in number and more relevant. Paul picks some
of the returned nicknames of patients and queries them with his interaction
constraints, proposing a knee-injury discussion in a Skype-based conference call
on the upcoming Saturday or Sunday any time between 10AM and 6PM EST.
Paul's query returns the Skype IDs of patients who want to reveal theirs and are
interested in the discussion, with the time narrowed down to Sunday between
3PM and 6PM EST. Hence, Paul invites them for a rst call Sunday, 4PM to
5PM, e ectively initiating a knee-injury subgroup of the leg-injury group.</p>
      <p>It should be noted that Paul by using the PatientSupporter Social
Semantic Web portal is able to initiate the virtual subgroup about his sports injury
on a global scale. He also bene ts from PatientSupporter's interoperation
facility in the background { to transform patient pro les between Pure Prolog and
N3 through RuleML/XML. The system employs a partonomy of
sports-injurya ected body parts, which makes it easy for Paul to navigate hierarchically up or
down, increasing recall or precision, respectively. Paul's queries invoke other
patients' interaction rules, allowing him to narrow down his search in a step-wise
fashion. All of this saves him from browsing through a large set of irrelevant
patient pro les and permits him to e ciently converge on a rst Skype call.</p>
      <p>The rest of the paper is organized as follows. Section 2 presents the design
goals of the PatientSupporter instantiation of Rule Responder. Section 3
discusses the global knowledge base used by the OA. Section 4 describes the use of
local knowledge bases to represent the pro les of individual patients underneath
the PAs. Section 5 expands upon the RuleML-based interoperation of Pure
Prolog and N3 rules. Section 6 explains and demonstrates the use of RuleML-based
querying for patients in a distributed setting. Section 7 concludes the paper and
discusses future work.
2</p>
      <sec id="sec-3-1">
        <title>Instantiating Rule Responder to PatientSupporter</title>
        <p>
          PatientSupporter is based on Rule Responder, where this reference architecture
with each of its main agent types (i.e., EA, OA, and PAs) is instantiated as
described in the following. It performs virtual support group matchmaking by
querying patients organized in a disease ontology { here, a body partonomy. The
following design goals have been pursued while developing PatientSupporter:
1. Identify a language of appropriate expressiveness to model patient pro les
from the family of RuleML languages [
          <xref ref-type="bibr" rid="ref3">3</xref>
          ], Pure Prolog [
          <xref ref-type="bibr" rid="ref20">20</xref>
          ], N3 [
          <xref ref-type="bibr" rid="ref2">2</xref>
          ], etc.
2. Identify a language for light-weight ontologies of sports injuries such as
subPartOf partonomies mapped to subClassOf taxonomies in RDFS or
OWL 2. The ontology language is to be combined with the rule language.
3. Allow eliciting rule and ontology de nitions in human-oriented syntaxes,
while translating the resulting knowledge to and from RuleML/XML,
RIF/XML [
          <xref ref-type="bibr" rid="ref7">7</xref>
          ], or XCL2 / CL RuleML5 for interchange.
4. Allow di erent rule engines (e.g., OO jDREW6 [
          <xref ref-type="bibr" rid="ref1">1</xref>
          ], Prova7 [
          <xref ref-type="bibr" rid="ref15">15</xref>
          ], and Euler8)
to execute global and local rulebases.
5. Allow rules as well as queries and their answers to be transmitted over an
        </p>
        <p>Enterprise Service Bus (ESB) { e.g., Mule9 or Apache ServiceMix.
6. Investigate the appropriateness of languages, engines, and GUIs for rules as
well as ontologies, to express, process, and transform the knowledge required
in patient pro les.
7. Elicit exemplary patient pro les and abstract them to generally usable pro le
templates for increased usability and reusability.
8. Guide students { e.g., of Computer Science, Medicine, or Kinesiology { when
forming and evolving virtual sports-injury support groups with
PatientSupporter.
9. Evaluate the e ectiveness and usefulness of the distributed PatientSupporter
architecture, based on its ESB-interconnected engines using di erent
languages for the dynamic formation of virtual patient support groups.
10. Adapt PatientSupporter from the sports-injury use case to other medical
domains such as weight control, food allergies, oral health, or (seasonal) u.</p>
        <p>
          The current implementation of PatientSupporter has focused on goals 1.-7.
It models patient pro les in POSL [
          <xref ref-type="bibr" rid="ref5">5</xref>
          ] and N3 [
          <xref ref-type="bibr" rid="ref2">2</xref>
          ]. The pro les are
interoperated through RuleML/XML as the intermediate format. Enquiring users are
aided by an English-XML-bridging menu-based form.10 Knowlege about patients
and their injuries is organized using rules combined with light-weight ontologies
in sorted (typed) Horn logic or N3. The subPartOf partonomy is mapped to
subClassOf in RDFS.11 Human-oriented syntaxes (of POSL and N3) have been
used while modeling the patient pro les. The overall communication and
coordination of the rule engines (e.g., OO jDREW, Prova, and Euler) has been
organized through Mule, an open-source ESB. The use of an ESB allows
architectural exibility by decoupling the functional components of Rule Responder
from the communication components [
          <xref ref-type="bibr" rid="ref11">11</xref>
          ].
        </p>
        <p>Rule Responder's instantiation to PatientSupporter in the sports-injury
domain allows to create virtual patient organizations consisting of virtual support
groups that are de ned through sports injuries structured by a partonomy of
affected body parts (further explained in Section 3). Speci cally, the OA becomes
an assistant to the entire virtual patient organization. Each PA becomes an
assistant to a group of patients having the same class of injuries from the partonomy,
5 http://wiki.ruleml.org/index.php/Relax NG
6 http://www.jdrew.org/oojdrew/
7 http://www.prova.ws/
8 http://eulersharp.sourceforge.net/
9 http://www.mulesoft.org/
10 http://ruleml.org/PatientSupporter/RuleResponder.html
11 http://ruleml.org/PatientSupporter/ les/PS-Taxonomy.rdf
and helps them as pro le users to get organized as a support group. The EA
is utilized by patients as enquiry users to (register with its virtual organization
and) query the pro les of the virtual organization's other patients.</p>
        <p>Rule Responder employs the following sequence of steps: An enquiry user
interacts with the EA to author and submit queries to the OA. The OA assigns
(maps and delegates) each query topic to the PA most knowledgeable about it.
Each PA poses the query to its local rulebase, and returns the derived answer(s)
to the OA. The OA checks the answer(s) before giving them back to the EA,
hence to the enquiry user.</p>
        <p>By default, the OA does not reveal the identity of the nicknamed patient(s)
behind the answering PA(s). Keeping the personal information hidden in this
way, the OA acts as a mediator that helps protect the privacy of pro les of
patients in the virtual organization. For participating in PatientSupporter-scheduled
online discussions via Skype, MSN, etc., or via a (smart)phone, patients might
also use dedicated (Skype, MSN, etc.) IDs or phones. However, if support group
participants do not want to reveal even their voice, they have to resort to typing
via chat or SMS. On the other hand, after a few discussions some within the
same virtual support group may decide to reveal their everyday identities to
selected or all participants.</p>
        <p>
          Rule Responder's earlier instantiations include SymposiumPlanner [
          <xref ref-type="bibr" rid="ref12">12</xref>
          ] and
WellnessRules [
          <xref ref-type="bibr" rid="ref8">8</xref>
          ], where WellnessRules extended Rule Responder with multiple
participant pro les underneath each PA. PatientSupporter further extends the
functionality of Rule Responder by making Social Semantic use of partonomies,
mapped to taxonomies: Patient injuries are classi ed in the hierarchical
partwhole manner of a ected body parts. For example, injuries related to Foot are
subordinated to those of Leg. Similarly, Heel and Toe injuries are subordinated
to those of Foot. Employing partonomies as light-weight ontologies in this way
allows the `re nement' of a virtual support group (e.g., about Leg injuries) into
subgroups (e.g., about Foot injuries and further about Heel and Toe injuries).
        </p>
        <p>PatientSupporter in extension to WellnessRules allows users to be supported
by PAs as follows: Each patient (as a pro le user) publishes a pro le employed
by the responsible PAs to respond to queries (from enquiry users) about his or
her preferences, constraints, etc. This dynamic pro le association is implemented
via the Pro le Responsibility Matrix (PRM), and is not possible in
SymposiumPlanner, where only chairs (as pro le users) are supported by PAs.</p>
        <p>The main agent types of PatientSupporter are described in the following
subsections. Figure 1 depicts the interaction between the EA, OA, and PAs.
2.1</p>
        <sec id="sec-3-1-1">
          <title>External Agent</title>
          <p>The External Agent (EA) is the point-of-contact that allows a patient to query
the Organizational Agent (OA) of a virtual patient organization. It is based on a
Web interface that allows him or her as an enquiry user to compose queries
employing a menu-based form, which uses JavaScript to generate both an English
description and RuleML/XML, thus making it easy to query other patients'
proles. A sports-injury patient primarily selects the injury class from the
partonomy. He or she can then ll in property values about diseases and treatments as
well as interaction constraints. The nished RuleML/XML query is submitted
to the OA. Finally, the EA presents the OA's answer(s) to the patient.
2.2</p>
        </sec>
        <sec id="sec-3-1-2">
          <title>Organizational Agent</title>
          <p>The Organizational Agent (OA) is at the center of PatientSupporter,
representing a virtual patient organization as a whole. The knowledge base of the OA is
global across the virtual organization, and is written and run in the language and
engine Prova. The OA also employs two matrices, on the basis of which incoming
queries are mapped and delegated: The Group Responsibility Matrix, written as
an OWL-Lite ontology, de nes which group headed by a PA is best for which
kind of query. The Pro le Responsibility Matrix, written as an XML document,
de nes which patient pro les exist in a PA's group, and in which formats (here,
POSL or N3).
2.3</p>
        </sec>
        <sec id="sec-3-1-3">
          <title>Personal Agent</title>
          <p>The Personal Agents (PAs) contain disease-oriented groups of patient pro les,
where diseases are restricted to sports injuries. Each PA heads the group of
patient pro les listed in the Pro le Responsibility Matrix (cf. Section 2.2). The
knowledge base of facts and rules of each pro le under a PA is local to that
pro le, and is either written in POSL and run in OO jDREW or is written in
N3 and run in Euler.</p>
        </sec>
      </sec>
      <sec id="sec-3-2">
        <title>Global Knowledge Base for Virtual Organization</title>
        <p>The ontologies and a subset of the rules are globally shared via the OA to bene t
all the PAs. Another subset of rules is distributed amongst the PAs, where it is
kept local (cf. Section 4). The shared ontology and the shared subset of rules
are referred to as the global knowledge base, which is complemented by a shared
signature document.</p>
        <p>Global knowledge in PatientSupporter is modeled as a combination of
ontologies and rules, where rule arguments are de ned by signatures. The
ontologies include a light-weight ontology realizing the Group Responsibility Matrix
(cf. Section 2.2) and a body partonomy. The global rules include general
constraints and preferences of the virtual organization. PatientSupporter makes use
of the standard rule format RuleML/XML and the Rule Responder framework
to transform to and from other rule languages.</p>
        <p>
          The body partonomy was elicited as a commonsense ontology to re ect the
patient-centric perspective of support groups. It is drawing, among others, on
the Digital Anatomist Foundational Model of Anatomy (FMA) [
          <xref ref-type="bibr" rid="ref18">18</xref>
          ], the online
Sports Injury Clinic [
          <xref ref-type="bibr" rid="ref21">21</xref>
          ], and the knowledge of a medically trained NRC-IIT
colleague. It is referred to as a partonomy because it represents the logical
hierarchy of body parts. However, it is realized as a taxonomy of injuries a ecting the
body parts. Thus, A subPartOf B implies A Injury subClassOf B Injury. Note
that we do not express what (possibly still undiagnosed) injury it is, but only
the (unlateralized etc.) body part where it is. This representation is proposed as
an appropriate level of abstraction for nding patients with sports injuries, but
could be re ned for other purposes (cf. Section 7).
        </p>
        <p>Under the root Body, PatientSupporter uses the partonomy classes Head,
Neck, Shoulder, Arm, Torso, Back, and Leg. All of Thigh, Lower Leg, Knee,
and Foot are regarded as direct parts of Leg. Toe and Heel are likewise part of
Foot. The complete partonomy is shown in Figure 2. Its implementation as a
subClassOf taxonomy in RDFS is available online.11</p>
        <p>The rule component in PatientSupporter employs POSL with Horn logic
plus Negation as failure (Naf) and N3 with scoped Naf. The use of Naf Hornlog
POSL has been restricted to atoms with positional arguments,12 leaving
F-logiclike frames with property-value slots to N3. This demonstrates the range of our
approach through complementary rule styles.13</p>
        <p>The Naf Hornlog POSL sublanguage uses (positional) n-ary relations (or,
predicates) as its central modeling paradigm. N3 instead uses (unordered) sets
of binary slots (or, properties) centered around object identi ers (OIDs, called
`subjects' in RDF and N3).
12 The POSL syntax thus corresponds to pure-Prolog syntax except that POSL
variables are pre xed by a question mark while Prolog variables are upper-cased.
13 To didactically exemplify the positional and slotted styles as well as POSL-N3
interoperation, the online PatientSupporter prototype redundantly keeps rulebases both
as .posl and as .n3 documents.</p>
        <p>The following POSL example indicates the positional signature of the 16-ary
predicate myDiscussion:
myDiscussion(?ProfileID,?Injury,?MinAge,?MaxAge,?MinRSVP,?MaxRSVP,?Category,?Treatment,
?HealingStage,?StartTime,?EndTime,?Duration,?Channel,?Contact,?Gender,?TimeZone).</p>
        <p>Fig. 2. Patient-centric body partonomy for localizing sports injuries</p>
        <p>In N3 this becomes a slotted signature with subject :myDiscussion, an
rdf:type of :MyDiscussion, and the 16 arguments as the remaining slots:
_:myDiscussion
rdf:type :MyDiscussion;
:profileID ?ProfileID
:injury ?Injury;
:minAge ?MinAge;
:maxAge ?MaxAge;
:minRSVP ?MinRSVP;
:maxRSVP ?MaxRSVP;
:category ?Category;
:treatment ?Treatment;
:healingStage ?HealingStage;
:startTime ?StartTime;
:endTime ?EndTime;
:duration ?Duration;
:channel ?Channel;
:contact ?Contact;
:gender ?Gender;
:timeZone ?TimeZone.</p>
        <p>
          The complete signatures are being maintained in a global document.14
While rules (including underlying facts) according to a positional signature
are usually more concise, positional arguments must be speci ed in their xed
order (with missing or inapplicable arguments represented by `null values').
Conversely, while a slotted signature usually makes rules more verbose, slotted
arguments can be speci ed in any order (with missing or inapplicable arguments
just becoming omitted). The Datalog special case of the positional paradigm
(i.e., Hornlog without complex arguments) corresponds to the relational model
in that facts with the same predicate correspond to relational tables, and rules
to relational views. Conversely, the slotted paradigm is a special case of
objectoriented models where objects (`subjects') are declaratively described by slots
and can inherit slot values, but slot values are not procedurally updated.
Depending on their previous experience with these paradigms (e.g., with relational
databases or RDF metadata), whose characteristics transpire even in GUIs,
virtual organizations or individual patients can take advantage of their favorite one.
For a synthesis of the two paradigms see [
          <xref ref-type="bibr" rid="ref6">6</xref>
          ].
        </p>
        <p>Shared rules de ning PatientSupporter predicates have been collected for the
rulebase of the OA. They, together with the signatures and ontologies, formalize
the global knowledge of the PatientSupporter system.</p>
        <p>An example of a POSL (`backward') rule de nes participation in a virtual
support group as follows:
participation(?ProfileID,?Injury,?MinRSVP,?MaxRSVP)
:groupSize(?ProfileID,?Injury,?Min,?Max),
greaterThanOrEqual(?MinRSVP,?Min),
lessThanOrEqual(?MaxRSVP,?Max).</p>
        <p>The rst argument of the conclusion predicate participation is the patient
(?ProfileID) the rule is instantiated for, followed by a lesion (?Injury)
argument, followed by the minimal (?MinRSVP) and maximal (?MaxRSVP) number of
14 http://ruleml.org/PatientSupporter/Signatures/
participants the querier wants to have in a group for the lesion. The rule succeeds
for its four positional arguments if ?ProfileID's desired group size (groupSize)
is between ?Min and ?Max, ?MinRSVP ?Min, and ?MaxRSVP ?Max.</p>
        <p>The corresponding N3 (`forward') rule for deriving :participation facts is
as follows, where the ?rsvpQuery premise does not correspond to a premise of
the POSL rule but is needed to bind the `input' arguments of its conclusion:
}.
?rsvpQuery
rdf:type :RSVPQuery;
:profileID ?ProfileID;
:injury ?Injury;
:minRSVP ?MinRSVP;
:maxRSVP ?MaxRSVP.
?groupSize
rdf:type :GroupSize;
:profileID ?ProfileID;
:injury ?Injury;
:min ?Min;
:max ?Max.
?MinRSVP math:notLessThan ?Min.
?MaxRSVP math:notGreaterThan ?Max.
_:participation
rdf:type :Participation;
:profileID ?ProfileID;
:injury ?Injury;
:minRSVP ?MinRSVP;
:maxRSVP ?MaxRSVP.</p>
        <p>The global OA knowledge base is being maintained in both language
paradigms,13 i.e. POSL15 and N316.
4</p>
      </sec>
      <sec id="sec-3-3">
        <title>Locally Distributed Knowledge Bases for Patients</title>
        <p>Locally distributed knowledge bases are grouped as pro les underneath the PAs.
Each PA group has its own kind of knowledge base, according to the medical
subarea associated with the body partonomy (cf. Section 3). For example, the
pro les created by patients with Leg injuries are kept with the Leg PA.</p>
        <p>The local knowledge bases have information about patients to model their
pro les using the following vocabulary of properties: A unique identi er of a
pro le, ProfileID; the kind of injury of the patient, Injury; the age of the
patient, Age; the time zone of the the patient, TimeZone; the treatment
required, Treatment; the stage of healing of the injury, HealingStage; and the
category information, Category. The properties Treatment, HealingStage, and
Category have the following allowed value ranges: The Treatment property
currently has one of the values Bandage, MajorOperation, MediumOperation,
15 http://ruleml.org/PatientSupporter/resources/OA/PS-Global.posl
16 http://ruleml.org/PatientSupporter/resources/OA/PS-Global.n3
MinorOperation, MajorMedication, MediumMedication, MinorMedication, or
ChangeOfLifeStyle; the HealingStage property has values Fresh, Medium,
Convalescent, or Healed; and the Category property has values In or Out
patient.</p>
        <p>For example, this is a local myDiscussion fact about p0001 according to
the positional signature of Section 3 (in POSL we use ?:Leg as an anonymous
variable of type Leg, assuming p0001 has one leg injury):</p>
        <p>Similarly, given below is its counterpart according to the slotted signature
(in N3 we use :Leg as a constant, again standing for one leg injury):</p>
        <p>Both express interest in a myDiscussion about Leg injuries, with Medium
stage of healing, Bandage level for treatment, and with category of Out patient.
It is proposed for June 1st, 2011, between 10:15 AM and 11:20 AM (GMT -4:00
Atlantic Time) for a duration of 30 minutes. It should have the form of a Skype
call for 5 to 10 people. The Skype user name of the person advertising this time
is John27.</p>
        <p>This fact (in POSL and N3) can be generated by a local rule (again, in both
paradigms) which uses another rule and facts to satisfy its premises. Given below
is an example of a positional POSL rule from the PA knowledge base of patient
p0001, de ning the main predicate myDiscussion about Leg injuries, specifying
his desired support-group discussion:
myDiscussion(p0001,?:Leg,?MinAge,?MaxAge,?MinRSVP,?MaxRSVP,?Category,?Treatment,?HealingStage,
dateTime[?StartYear,?StartMonth,?StartDay,?StartHour,?StartMinute],
dateTime[?EndYear,?EndMonth,?EndDay,?EndHour,?EndMinute],
dateTime[?DurYear,?DurMonth,?DurDay,?DurHour,?DurMinute],
?Channel,?Contact,?Gender,?TimeZone)
:ageCheck(p0001,?MinAge,?MaxAge,?Age),
participation(p0001,?:Leg,?MinRSVP,?MaxRSVP),
communication(p0001,?Channel,?Contact),
notEqual(?Channel,MSN),
category(p0001,?:Leg,?Category),
treatment(p0001,?:Leg,?Treatment),
healingStage(p0001,?:Leg,?HealingStage),
gender(p0001,?Gender),
timeZone(p0001,?TimeZone).</p>
        <p>The rule conclusion's myDiscussion predicate starts with the person's
prole ID, p0001, followed by the kind of injury, ?:Leg, the age limits ?MinAge
and ?MaxAge, the group limits ?MinRSVP and ?MaxRSVP, the patient ?Category
(In/Out), the ?Treatment and ?HealingStage to be discussed, the start time,
end time, and duration of the discussion, its communication ?Channel, as well
as p0001's ?Contact name, ?Gender, and ?TimeZone.</p>
        <p>The initial rule premises perform an ageCheck, test the participation
constraints (cf. rule in Section 3), and
lter on the communication ?Channel.</p>
        <p>The next premises query p0001's Possible ?:Leg-injury events and planned
duration for this discussion, making sure it is a goodDuration within the
event interval. The penultimate premises compute the category, treatment and
healingStage constraints. The nal premises concern the gender and timeZone.</p>
        <p>The corresponding slotted N3 rule is given, abridged, below:
{
}.</p>
        <p>:duration
:channel
:contact
:gender
:timeZone
?Channel;
?Contact;
?Gender;
?TimeZone.
[:year ?DurYear; :month ?DurMonth; :day ?DurDay; :hour ?DurHour;
:minute ?DurMinute];</p>
        <p>The POSL and N3 rules (and facts) for this and other ctitious patients are
available, as templates, online.17
5</p>
      </sec>
      <sec id="sec-3-4">
        <title>Interoperation between POSL and N3 Rules via</title>
      </sec>
      <sec id="sec-3-5">
        <title>RuleML/XML</title>
        <p>The PatientSupporter use case includes a testbed for the interoperation (i.e.,
alignment and translation) of information in knowledge bases in the two main
rule paradigms: Prolog-style (positional) relations and N3-style (slotted) frames.
PatientSupporter inherits the interoperation mechanisms from Rule Responder.
The interoperation methodology makes iterative use of alignment and
translation: An initial alignment permits the translation of parts of a hybrid knowledge
base. This then leads to more precise alignments, which in turn lead to better
translations. Using this methodology, PatientSupporter can maintain relational
(Pure Prolog) as well as frame (N3) versions of rules, both accessing the same,
independently maintained, body partonomy.</p>
        <p>The PAs of PatientSupporter can thus use either of these rule paradigms,
while interoperation is carried out through the intermediate rule language
RuleML/XML, which has sublanguages for both of them, so that the
crossparadigm translations can use the common XML syntax of RuleML. A pair of
online converters18 is used for rulebase conversion between the human-oriented
POSL syntax and its XML serialization in RuleML.</p>
        <p>For rulebase translation, the signatures of PatientSupporter relations and
frames are aligned in a shared signature document,14 discussed in Section 3,
which speci es the argument positions of relations and slot names of frames.
The alignment of sample relations and frames in Sections 3 and 4 then suggests
the actual translations between the two rule paradigms.</p>
        <p>
          Translations that are considered to be `static' or `at compile-time' take an
entire rulebase as input and return its entire transformed version in RuleML/XML.
Thus, an assumption of `closed-arguments' of xed signatures for relations and
frames is made [
          <xref ref-type="bibr" rid="ref8">8</xref>
          ].
        </p>
        <p>Positional-slotted translators for a version of RuleML are available online as
an XSLT implementation.19</p>
        <p>For example, POSL's myDiscussion relational fact of Section 4 is serialized
in positional RuleML as follows, where Individual constants are distinguished
from Data literals:
17 http://ruleml.org/PatientSupporter/resources/PA/
18 http://ruleml.org/posl/converter.jnlp
19 http://ruleml.org/ooruleml-xslt/oo2prml.html</p>
        <p>Extending the mappings in OO RuleML20, N3's myDiscussion frame fact
of Section 4 is serialized in slotted RuleML as follows, where RuleML's Rel
represents N3's rdf:type:</p>
        <p>While slotted-to-positional translation of atoms essentially xes the
argument order and omits the slot names, positional-to-slotted translation looks up
the slot names in the shared signature document.14 For the translation of a rule,
the above translation of atoms is applied to the atom in the conclusion and
to all the atoms in the premises. For a rulebase, the translation then applies
to all of its rules. With the above-discussed human-oriented syntax translators,
rulebases containing rules like the myDiscussion rule in Section 4 can thus be
translated from Pure Prolog to POSL to RuleML (positional to slotted) and to
N3, as well as vice versa. These translators permit rule, query, and answer
interoperation, via RuleML/XML, for the Rule Responder infrastructure inherited
by PatientSupporter.</p>
        <p>
          The translators have been complemented by mappings between the Dlex
subset of RuleML and of RIF [
          <xref ref-type="bibr" rid="ref4">4</xref>
          ].
        </p>
        <p>20 http://ruleml.org/indoo/n3ruleml.html</p>
      </sec>
      <sec id="sec-3-6">
        <title>Distributed Rule Responder Querying</title>
        <p>PatientSupporter inherits the distributed query mechanism from Rule
Responder. For querying di erent rule engines, transformations between queries and
answers from N3 and Pure Prolog through RuleML/XML are done as described
for rules in Section 5. Both the global knowledge base, described in Section 3,
and locally distributed knowledge bases, described in Section 4, are used in query
answering.</p>
        <p>Given below is an example of a POSL query for patient pro les, which is
executed by Rule Responder's OO jDREW TD (Top-Down) engine:</p>
        <p>It uses the rule from Section 4 to nd any patient (?ProfileID) who has
a Leg injury, age between 20:integer and 50:integer, and is interested in
joining a discussion group with minimum 5:integer to maximum 10:integer
people, where all the remaining arguments, indicated by `...', are left open as
free variables.</p>
        <p>This is the corresponding N3 query, to be executed by Rule Responder's
EulerSharp EYE bottom-up engine:
@prefix : &lt;patient_profiles#&gt;.
@prefix rdf:
&lt;http://www.w3.org/1999/02/22</p>
        <p>rdf-syntax-ns#&gt;.
_:myDiscussion
rdf:type
:profileID
:injury
:minAge
:maxAge
:minRSVP
:maxRSVP
... .</p>
        <p>:MyDiscussion;
?ProfileID;
:Leg;
:20;
:50;
:5;
:10;</p>
        <p>After having declared two pre xes, it builds an existential (` ') node,
:myDiscussion, using slots for the xed parameters and the fact-provided
?MinRSVP (5) and ?MaxRSVP (10) bindings to ll the variable slots again
indicated by `...'.</p>
        <p>Within our online test environment, the above sample query produces twelve
solutions. These can be narrowed down to produce four solutions by descending
the partonomy from ?Injury:Leg to ?Injury:Foot, and to two solutions when
?Injury:Foot becomes ?Injury:Toe. Using variations of such queries,
patientsas-enquiry-users of PatientSupporter will be able to explore pro les of
patientsas-pro le-users to nd or initiate a support group.</p>
        <p>In our experiments, the overall processing times for the online-selectable10
positional myDiscussion Example Queries 1-4 in Rule Responder instantiated
to PatientSupporter on average were, respectively, 11s (for 12 answers),
7s (for 5 answers), 5s (for 2 answers), and 4s (for 1 answer), measured for
Java JRE6 in Windows XP on an Intel Core 2 Duo 2.80GHz processor.</p>
        <p>The implemented Rule Responder instantiation for PatientSupporter, with
all source les and test queries, is available online.10</p>
      </sec>
      <sec id="sec-3-7">
        <title>Conclusions and Future Work</title>
        <p>PatientSupporter demonstrates the Social Semantic Subweb for patients who
want to collaborate and share information with each other about sports injuries,
on a global scale. It enables precise networking between patients by using
ontologies combined with rules to specify and query patient pro les. Key features of
PatientSupporter are: First, it permits interoperation of patient pro les between
Pure Prolog (Naf Hornlog) and N3 through RuleML/XML. Second, it enables
scalability of distributed knowledge on the Social Semantic Subweb via its PA
modularization, starting with derivation rules and light-weight ontologies. Third,
PatientSupporter uses the OO jDREW, Euler, and Prova engines, while its open
Rule Responder architecture makes it easy to bring in new engines. Fourth, it
makes use of a body partonomy for modeling sports injuries in a hierarchical
manner (from the patients' commonsense point-of-view). Fifth, it makes use of
ontologies and rules to precisely search for patient pro les, and allows enquiry
users to narrow down their search in a step-wise fashion. Hence, by delivering
the relevant pro les, PatientSupporter saves enquiry users from the hassle of
browsing through a large set of patient pro les.</p>
        <p>
          While the querying of patient rulebases by enquiry users is pretty well
supported with a menu-based GUI10, the editing of patient rulebases by pro le users
should be similarly supported. Especially for newcomers, the choice between
positional, slotted, and combined language paradigms could be abstracted away as
far as possible: A new pro le user would visually select the features relevant for
their pro le and the underlying system would generate the pro le in the
language most appropriate for this selection. In future work, controlled or natural
language interfaces could be developed for both querying and editing, following
the ACE query interface of SymposiumPlanner-2011 [
          <xref ref-type="bibr" rid="ref22">22</xref>
          ], and information
extraction methods could be explored as an alternative to `from-scratch' pro le
editing.
        </p>
        <p>In a separate e ort, PatientSupporter's current vocabulary of properties
could be re ned { and rules over them could be written { to express multiple
injuries to the same body part, injuries of multiple body parts, indirect
symptoms, lab results, as well as speci cs about diagnoses and therapies. Besides the
treatment of injuries, their prevention could be represented.</p>
        <p>
          An extension of PatientSupporter could include { along with the patients
and their Social Semantic pro les { medical professionals and Personal Health
Records (PHRs) [
          <xref ref-type="bibr" rid="ref17">17</xref>
          ]. This would assist in the formation of virtual support groups
consisting of doctors and nurses as well as patients, based on the preferences and
constraints of all three subgroups. For this, patients' commonsense knowledge
and pro les should be mapped to medical expert knowledge and PHRs { and
(partially) vice versa. For example, PatientSupporter's body partonomy for
localizing global knowledge about sports injuries could (be mapped to a full-blown
medical ontology such as SNOMED and) act as an index into medical knowledge
about anatomy, physiology, etc. as it pertains to sports injuries. A medical
professional could then provide injury-speci c knowledge that is not patient-speci c
to the entire support group, rather than repeating it for each patient.
        </p>
        <p>
          PatientSupporter and its use cases will thus provide new challenges and
suggestions for improvements of RuleML, Rule Responder, and the involved engines.
Since PatientSupporter rules are interoperated through RuleML/XML, they can
also be ported from Rule Responder to other Social Semantic Web frameworks
such as EMERALD [
          <xref ref-type="bibr" rid="ref16">16</xref>
          ] or be read into another Java-based system via JAXB.
8
        </p>
      </sec>
      <sec id="sec-3-8">
        <title>Acknowledgements</title>
        <p>The authors would like to thank colleagues at NRC-IIT Fredericton, especially
Benjamin Craig and Julie Maitland, for helpful discussions. We also thank
Zainab Almugbel, Usman Ali Chaudhry, and Sujan Saha, as well as the
organizers, reviewers, and participants of CSWS2011 for valuable feedback. NSERC is
thanked for its support through a Discovery Grant for Harold Boley. The work
by Omair Sha q, Derek Smith, and Taylor Osmun was done during their stays
at NRC-IIT.</p>
      </sec>
    </sec>
  </body>
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