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    <article-meta>
      <title-group>
        <article-title>The Epidemic Marketplace Platform: towards semantic characterization of epidemiological resources using biomedical ontologies</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Francisco M. Couto</string-name>
          <email>fcouto@di.fc.ul.pt</email>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>João D. Ferreira</string-name>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>João Zamite</string-name>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Carlos Santos</string-name>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Tiago Posse</string-name>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Paulo Graça</string-name>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Dulce Domingos</string-name>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Mário J. Silva</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>IST, INESC-ID, Technical University of Lisbon</institution>
          ,
          <country country="PT">Portugal</country>
        </aff>
        <aff id="aff1">
          <label>1</label>
          <institution>Lasige, Departamento de Informática, Faculdade de Ciências da Universidade de Lisboa</institution>
          ,
          <country country="PT">Portugal</country>
        </aff>
      </contrib-group>
      <abstract>
        <p>This software demonstration paper presents the Epidemic Marketplace, a platform for integrating and sharing epidemiological data. It uses its own semantic metadata model for characterizing the resources submitted, which integrates a network of epidemiology related ontologies. The Epidemic Marketplace platform is available at http://www.epimarketplace.net/.</p>
      </abstract>
    </article-meta>
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  <body>
    <sec id="sec-1">
      <title>INTRODUCTION</title>
      <p>
        The Epidemic Marketplace is a platform for integrating and
sharing epidemiological data, which aims at supporting
transparent, seamless access to distributed, heterogeneous and redundant
resources
        <xref ref-type="bibr" rid="ref3 ref4">(Silva et al., 2010)</xref>
        . The development of this platform is
one of the goals of EPIWORK, a multidisciplinary European
research project funded by a Future and Emerging Technologies (FET)
Proactive initiative, aimed at developing the appropriate framework
of tools and knowledge needed for the design of epidemic forecast
infrastructures.
      </p>
      <p>
        The Epidemic Marketplace uses its own semantic metadata model
for characterizing the submitted resources
        <xref ref-type="bibr" rid="ref3">(Lopes et al., 2010)</xref>
        . To
improve the system interoperability, the semantic metadata model
is internally mapped to the Dublin Core Metadata Element Set, a
standard way to describe web-based information resources.
However, the integration of available ontologies in the semantic metadata
model will has a crucial role on enhancing data integration and
the consistency and coherency of their semantic characterization.
Thus, we proposed a Network of Epidemiology Related
Ontologies, dubbed NERO, that establishes a collection of ontologies to
be integrated in the Epidemic Marketplace’s metadata model
        <xref ref-type="bibr" rid="ref2">(Ferreira et al., 2012)</xref>
        . Ontology matching techniques will be used
to align shared concepts between ontologies
        <xref ref-type="bibr" rid="ref1">(Cruz et al., 2011)</xref>
        .
The network will provide a source of concepts to characterize
epidemiological resources.
      </p>
      <p>The usage of ontologies enables the restriction of the semantic
characterization of every resource to standard and unambiguous
terms, making the information retrieval and analysis of the
stored resources more effective. Additionally, it also facilitates the
semantic characterization process, for example by providing term
suggestions according to the user profile and their previous resource
submissions.</p>
    </sec>
    <sec id="sec-2">
      <title>USER INTERFACE</title>
      <p>The platform provides a web user interface to upload,
characterize, browse, search, download, request and comment the epidemic
resources and their metadata. The resources are disseminated under
access policies that can be personalized.</p>
      <p>The interface was developed using Drupal, a highly customizable
free software package for the organization, management and
distribution of any content 1. The resources are stored in a repository
based on Fedora Commons, a general-purpose, open-source digital
object repository system 2.</p>
      <p>Figure 1 shows an example of the resources returned by the
platform when searching for flu in 2010 and by ordering them by date
(oldest first). This is just an example of a generic search, but more
specialized filters based on ontological terms may be performed.</p>
      <p>The resources and their metadata are also directly accessible
through the set of RESTful web services that are invoked by the
user interface to store and manage the resources. These web
services are currently being used by computational applications that
require automatic retrieval, search, upload, update or removal of
resources stored in the Marketplace platform. For example, these
web services are currently being used to store simulation data from
the GleamViz simulator 3, tweets retrieved by the MEDCollector
4, and monitorization data gathered by the Influenzanet system 5.
The web services also enable computational applications to manage
group-based access control policies. The detailed specification of
these web services is presented on the platform’s web site. 6.
3</p>
    </sec>
    <sec id="sec-3">
      <title>CONCLUSION</title>
      <p>This software demonstration paper presents the Epidemic
Marketplace, a platform that enables users to semantically characterize
their resources in a standard way by exploiting the knowledge
encoded in a comprehensive network of epidemiologically
relevant ontologies. This model not only enhances the characterization
process, but also provides the community with an important asset
by its own, and improves the integration, retrieval and analysis of
resources.
1 http://www.drupal.org/
2 http://www.fedora-commons.org/
3 http://www.gleamviz.org/simulator/
4 http://vimeo.com/14734417
5 http://www.influenzanet.eu/
6 http://www.epimarketplace.net/developers_corner/
web_services</p>
      <p>The goal is to provide a unified and integrated platform for the
management of epidemic resources, which will be semantically
characterized by extensively exploiting the knowledge encoded in
available ontologies. This platform will eventually serve as the
basis for a distributed information reference for epidemic modelers,
which will further aid the communication within the community of
epidemiologists and the sharing of their knowledge.</p>
    </sec>
    <sec id="sec-4">
      <title>ACKNOWLEDGEMENTS</title>
      <p>The authors want to thank the European Commission for the
financial support of the EPIWORK project under the Seventh
Framework Programme (Grant #231807) and the Portuguese
Fundação para a Ciência e Tecnologia through the financial support
of the SOMER project (PTDC/EIA-EIA/119119/2010), the PhD
grant SFRH/BD/69345/2010, through the PIDDAC Program funds
(INESC-ID multi annual funding) and through the LASIGE
multiannual support.</p>
    </sec>
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