<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Archiving and Interchange DTD v1.0 20120330//EN" "JATS-archivearticle1.dtd">
<article xmlns:xlink="http://www.w3.org/1999/xlink">
  <front>
    <journal-meta />
    <article-meta>
      <title-group>
        <article-title>Virtual Prosthodontic Planning for Oral Rehabilitation: a Pilot Study</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Jaafar Abduo</string-name>
          <email>jaafar.abduo@uwa.edu.au</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>School of Dentistry, University of Western Australia</institution>
          ,
          <addr-line>35 Stirling Highway, Crawley, WA 6009</addr-line>
          ,
          <country country="US">USA</country>
        </aff>
      </contrib-group>
      <fpage>34</fpage>
      <lpage>42</lpage>
      <abstract>
        <p>This report illustrates the application of digital work-up as a dental treatment planning tool for prosthodontic patients. A clinical case was selected according to the prosthodontic needs. The conventional work-up was performed in accordance with the traditional prosthodontic criteria. The digital work-up was comprised of scanning of the pre-treatment models followed by restoring the deficient teeth and replacement of the missing teeth. The two diagnostic work-up models were compared in relation to the modified teeth, soft tissue and occlusal contacts. It appears that the digital work-up is a feasible option and allows quantitative and qualitative evaluation of the dental treatment impact.</p>
      </abstract>
      <kwd-group>
        <kwd>diagnostics</kwd>
        <kwd>work-up</kwd>
        <kwd>dental rehabilitation</kwd>
        <kwd>dental prosthesis</kwd>
        <kwd>image registration</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>-</title>
      <p>
        Many patients suffer from dentally related problems such as missing or deficient
teeth, disorganized dental arches, or unacceptable tooth contour. Consequently, dental
clinicians commonly encounter situations were alteration in tooth contour is indicated.
Prosthodontics is the dental specialty that deals with the diagnosis, treatment
planning, rehabilitation and maintenance of the oral function, comfort, appearance and
health of these patients [
        <xref ref-type="bibr" rid="ref1">1</xref>
        ]. In many instances, prosthodontic treatment necessitates
irreversible alterations to the remaining hard tissues. In order to justify such
alterations, significant benefits of the treatment should be apparent. Therefore, to reach a
satisfactory outcome, comprehensive diagnostic planning and work-up should be
conducted before embarking on the definitive prosthodontic rehabilitation. Further,
the diagnostic work-up allows visualizing the outcome and helps in deciding on the
most adequate treatment plan for a specific case.
      </p>
      <p>
        For dental abnormalities, the conventional prosthodontic protocol involves
obtaining diagnostic models that represent the patient’s dental arches upon which the
diagnostic work-up can be performed. The complexity of the treatment ranges from single
or few teeth restorations, to the complete dentition. The planned treatment can involve
altering the tooth morphology, altering the vertical dimension of occlusion,
reorganizing the occlusion and restoring all the teeth of at least one dental arch [
        <xref ref-type="bibr" rid="ref2 ref3">2, 3</xref>
        ]. In the
dental laboratory, the diagnostic work-up involves preparing dental models, reducing
part of the teeth and building the contours with wax [
        <xref ref-type="bibr" rid="ref2 ref4">2, 4</xref>
        ]. The Ideal diagnostic
workup should be applicable, transferable, conservative and aesthetic. Three critical
criteria must be fulfilled. (1) The dental modifications should preserve the emergence
profile. Therefore, although the dental modifications can be significant at the incisal
or occlusal surfaces, they should be less prominent closer to the soft tissues. Further,
excessive reduction should be avoided as this can affect the health of dental pulp. (2)
The soft tissues should not be altered as they will aid in transferring the diagnostic
information. (3) The occlusal contacts should be accurately located against the
opposing teeth.
      </p>
      <p>
        The outcome of this “trial” treatment can be demonstrated to the patient for
approval or suggestion of any further modifications. In this manner, the patient will be
more informed of the final outcome. Subsequently, the diagnostic work-up will
facilitate the “outcome based treatment” which implies that the magnitude of irreversible
alteration to the teeth is dictated by the final outcome rather than the initial patient
presentation [
        <xref ref-type="bibr" rid="ref5 ref6">5, 6</xref>
        ]. This is accomplished clinically by preparing the teeth according to
the anticipated final prostheses design as determined by the diagnostic work-up. In
addition, provisional prostheses can be fabricated following the diagnostic work-up
and, should the provisional outcome satisfy the patient, the definitive prostheses will
be fabricated to resemble the diagnostic work-up [
        <xref ref-type="bibr" rid="ref5 ref6">5, 6</xref>
        ].
      </p>
      <p>More recently, with the advent of laser scanning, virtual planning, rapid
prototyping and computer-aided design and manufacturing, it is hypothesized that diagnostic
planning can accomplished in time-efficient and well-controlled fashion. This pilot
study introduces an additional application of computerized technologies that allows
virtual alteration of dental morphology. It is envisioned that the digitally modified
dentition can be used by the dental clinician and technician as a guide for the final
prosthesis. In addition the study evaluates the potential of digital work-ups in
producing acceptable outcome and compares the accuracy digital work-up to conventional
work-up.
2</p>
    </sec>
    <sec id="sec-2">
      <title>Materials and Methods</title>
      <p>Human research ethics approval was obtained from the Human Research Ethics
Committee of the University of Western Australia (RA/4/1/5097). A clinical case that
requires diagnostic work-up prior to prosthetic treatment was selected. A total of 9
teeth in the maxillary arch required treatment. 6 teeth required restoration and 3 teeth
required replacement. Maxillary and mandibular dental impressions were taken by
irreversible hydrocolloid impression material (Alginate, GC America, IL, USA). The
impressions were poured by dental stone (Buff Stone, Adelaide Moulding &amp; Casting
Supplies, South Australia, Australia). These models comprised the pre-treatment
situation. Each model was duplicated twice by reversible hydrocolloid material
(Megafeel, MKM System, Haanova, Slovakia). One set of models were treated by
conventional work-up and the other by digital work-up.
2.1</p>
      <p>Conventional Work-Up
The actual models were articulated on semi-adjustable articulator (Whip Mix,
Louisville, KY, USA) and modified by trimming and contour alterations with inlay wax
(VITA Zahnfabrik, Bad Sackingen, Germany). The required work-up modifications
were even bilateral occlusal contacts, symmetry between the two sides, and natural
teeth morphology (Fig. 1).</p>
      <p>The conventional work-up models were scanned by Micro-CT scanner (SkyScan,
Bruker, Kontich, Belgium). Virtual 3D Stereolithography (STL) images of the
maxillary and mandibular models were constructed from the Digital Imaging and
Communication Medicine (DICOM) images with the aid of DICOM viewing program
(InVesalius, Renato, Archer Technology of Information Centre, Campinas, São Paulo,
Brazil).
The maxillary and mandibular pre-treatment models were scanned by the Micro-CT
scanner and STL images were constructed. A 3D rendering software package
(Geomagic Studio, Raindrop Geomagic Inc., Research Triangle Park, NC, USA) was
used to complete the digital work-up. The maxillary and mandibular models were
virtually articulated by using the point-to-point alignment feature of Geomagic
Studio. To obtain aesthetic tooth morphology, physiological teeth moulds (Phonares
Teeth, Ivoclar Vivadent AG, Schaan, Liechtenstein) were scanned by the Micro-CT
scanner. Each virtual tooth was fitted manually on the model with the aim of
obtaining ideal teeth arrangement, emergence profile, symmetry and aesthetics. This is
followed by ensuring ideal occlusal contacts exist. The virtual tooth alignment involved
size alteration, rotation and translation (Fig. 2).
The comparison between each treatment protocol was performed digitally at three
levels; (1) tooth level, (2) soft tissue level, and (3) occlusion level. For the tooth level,
alterations in the contour are expected as long as the emerging portion of the tooth is
minimally affected and excessive reduction is avoided. Since the soft tissues are used
as landmarks, they should not be altered. The occlusal contacts should be
welldistributed and of comparable magnitude.</p>
      <p>
        To compare the tooth morphology, each work-up models was superimposed on the
pre-treatment model by the process of image registration. The image registration is
comprised of point-to-point registration followed global registration. Eventually, the
models were aligned through the best fit principles according to Iterative Closest
Point (ICP) algorithm [
        <xref ref-type="bibr" rid="ref7 ref8">7, 8</xref>
        ]. This step aimed to evaluate the amount of tooth
modifications that will be applied by each diagnostic work-up. The discrepancy distribution
between the superimposed models was illustrated in colour-difference maps to locate
the dimensional positive and negative deviations. The threshold value was set at 2
mm. The warm colours represent positive deviations, while the cold colours represent
negative deviations. The green colour indicates an optimal match.
      </p>
      <p>The soft tissue band closer to the teeth was trimmed from each model and
superimposed on the pre-treatment model. In addition to colour-difference maps
generation, the average 3D Euclidean Distance (ED) of 2000 random points of the common
surfaces of the two models was calculated. The absolute deviation values were used to
solely quantify the deviation magnitude. Therefore, the less mean distance between
the models, the better the accuracy of the diagnostic work-up.</p>
      <p>The occlusal contacts were measured by Meshlab Software (Visual Computing
Lab, University of Pisa, Italy). This was applied by measuring the distance between
the occlusal surface of each maxillary model and mandibular model. The threshold
value was set at 1 mm. According to the distance, the occlusal surface of each
maxillary model was colour coded. The red colour indicates contact and the blue colour
indicates lack of contact. Table 1 illustrates the comparison criteria of each level.
3
3.1</p>
    </sec>
    <sec id="sec-3">
      <title>Results</title>
    </sec>
    <sec id="sec-4">
      <title>Teeth Comparison</title>
      <p>Following the image registration of each work-up model, the unrestored teeth were
closely matched. This confirmed the accuracy of the registration process.</p>
      <p>In relation to the conventional work-up (Fig. 3), the occlusal plane and teeth
alignment were even. The symmetry between each side was observed. In general, the
restored teeth were enlarged. Emergence profile was preserved and the teeth gradually
enlarged toward the occlusal and incisal surfaces, where the enlargement was most
excessive. The central incisor had more reduction (about 1 mm) on its facial aspect.
This amount of reduction appears to be within the clinical acceptability.</p>
      <p>The digital work-up (Fig. 4), had similar presentation in relation to occlusal plane,
teeth alignment and symmetry. In general, the modified teeth exhibited greater
definition than conventional work-up which can contribute to more aesthetic appearance.
The emergence profile and enlargement features are similar to the conventional
workup. The amount of reduction on the facial aspect of the central incisor was less
prominent than for the conventional work-up.
The average ED between the pre-treatment and the conventional work-up models was
0.152 mm (SD = 0.06 mm). Greater average ED value was observed between the
pretreatment and the digital work-up models (0.779 mm, SD = 0.856 mm). This indicates
that alteration of the soft tissue contour by the conventional work-up is less than the
alteration by the digital work-up. The colour-difference maps illustrated that greater
discrepancy magnitudes exist closer to the teeth for digital work-up model (Fig. 5).
For the two work-up models, all the opposed teeth were in contact with the
mandibular teeth (Fig. 6). It appears that the contact for the conventional work-up was more
even in magnitude and distribution. Still, both of them improved the occlusal contacts
in comparison with the pre-treatment model.</p>
      <p>Fig. 6. Occlusal contacts on the maxillary teeth. Top: Pre-treatment model. Bottom
left: Conventional work-up model. Bottom left: Digital work-up model.</p>
    </sec>
    <sec id="sec-5">
      <title>Discussion</title>
      <p>Today, with patients’ high aesthetic expectations, the possible high standard of
treatment and the risk of legal litigations, more emphasis has to be placed on the
diagnostic work-up to allow the patient to visualize the final outcome. On the basis of
accurate planning, the patient will be able to provide consent after being fully informed by
observing the diagnostic work-up outcome. However, it is common for the clinician
to omit the diagnostic work-up procedure, or to leave it to dental technicians to
decide. The reason behind this is that the conventional diagnostic work-up is a time
consuming process and requires special training and artistic abilities. The technicians
might have the expertise in developing natural looking dental morphology; however,
they commonly lack the visualization of the biological parameters. Therefore, the
predictable application of the diagnostic work-up is limited to clinicians with a special
level of training.</p>
      <p>
        It is speculated that the introduced digital work-up approach will alleviate many of
the difficulties associated with conventional work-up. In addition, digital work-up
exhibits several advantages that justify its routine application. For example, the
process is completed virtually and requires no physical material which has significant
economical implication. The pre-treatment models are not altered and can be
preserved in the patient record. The applicability and efficiency of this technique are
further augmented by automation of the tooth modification process. The evaluation of
the implications of the diagnostic work-up is a useful feature to analyze the feasibility
of the proposed treatment [
        <xref ref-type="bibr" rid="ref9">9</xref>
        ]. It is expected that this feature will enhance patient’s
communication and reviewing dental modifications with relative ease.
      </p>
      <p>
        In the era of digital dentistry, it is more likely in the future that digital dental
impression will become popular [
        <xref ref-type="bibr" rid="ref10">10</xref>
        ]. Therefore, models manipulation will be purely
virtual, which will omit the conventional impression taking, model pouring and
subsequent scanning. To enhance the applicability of the digital work-up, actual models
can be produced by rapid prototyping technology. The printed model is envisioned to
provide direct guidance to the involved dental clinician and technician.
      </p>
      <p>The digital protocol appears to be promising and very comparable to conventional
protocol. In fact the high tooth definition implies that the computerized protocol can
produce more aesthetic treatment planning. However, the tooth-soft tissue junction
appears to be more affected with the digital work-up than conventional work-up. This
was illustrated by the greater ED for the digital work-up. Certainly, greater soft tissue
accuracy is always desirable, although the clinical significance of the reported
discrepancies cannot be confirmed.
5</p>
    </sec>
    <sec id="sec-6">
      <title>Conclusion</title>
      <p>This pilot study confirms the applicability of digital treatment planning and tooth
modifications for patients presenting with deficient or missing teeth. In addition, the
proposed approach allows the quantitative and qualitative diagnostic evaluations of
the impact of dental treatment on the existing dentition. In relation to accuracy, the
conventional protocol is more accurate at soft tissue and occlusion levels; however
this observation should be validated with greater sample number.
Acknowledgements. The author thanks Professor Mohammed Bannamoun for his
guidance on the project. The author acknowledges the facilities, the scientific and
technical assistance of the National Imaging Facility at the Centre for Microscopy,
Characterization &amp; Analysis, University of Western Australia, a facility funded by the
University, State and Commonwealth Governments. This paper is part of a project
supported the Research Development Award from the University of Western
Australia and the Raine Priming Grant.</p>
    </sec>
  </body>
  <back>
    <ref-list>
      <ref id="ref1">
        <mixed-citation>
          <article-title>1. The Glossary of Prosthodontic Terms</article-title>
          .
          <source>J. Prosthet. Dent</source>
          .
          <volume>94</volume>
          ,
          <fpage>10</fpage>
          -
          <lpage>92</lpage>
          (
          <year>2005</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref2">
        <mixed-citation>
          2.
          <string-name>
            <surname>Keough</surname>
            ,
            <given-names>B.</given-names>
          </string-name>
          :
          <article-title>Occlusion-Based Treatment Planning for Complex Dental Restorations: Part 1</article-title>
          .
          <string-name>
            <surname>Int</surname>
          </string-name>
          .
          <source>J. Periodontics. Restorative. Dent</source>
          .
          <volume>23</volume>
          ,
          <fpage>237</fpage>
          -
          <lpage>247</lpage>
          (
          <year>2003</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref3">
        <mixed-citation>
          3.
          <string-name>
            <surname>Besimo</surname>
            ,
            <given-names>C.E.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Rohner</surname>
            <given-names>H.P.</given-names>
          </string-name>
          :
          <article-title>Three-Dimensional Treatment Planning for Prosthetic Rehabilitation</article-title>
          .
          <source>Int. J. Periodontics. Restorative. Dent</source>
          .
          <volume>25</volume>
          ,
          <fpage>81</fpage>
          -
          <lpage>87</lpage>
          (
          <year>2005</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref4">
        <mixed-citation>
          4.
          <string-name>
            <surname>Abduo</surname>
            ,
            <given-names>J.:</given-names>
          </string-name>
          <article-title>An Innovative Prostheses Design for Rehabilitation of Severely Mutilated Dentition: a Case Report</article-title>
          .
          <source>J Adv. Prosthodont</source>
          .
          <volume>3</volume>
          ,
          <fpage>37</fpage>
          -
          <lpage>42</lpage>
          (
          <year>2011</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref5">
        <mixed-citation>
          5.
          <string-name>
            <surname>Magne</surname>
            ,
            <given-names>P.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Belser</surname>
          </string-name>
          , U.C.:
          <article-title>Novel Porcelain Laminate Preparation Approach Driven by a Diagnostic Mock-Up</article-title>
          .
          <source>J. Esthet. Restor. Dent</source>
          .
          <volume>16</volume>
          ,
          <fpage>7</fpage>
          -
          <lpage>16</lpage>
          (
          <year>2004</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref6">
        <mixed-citation>
          6.
          <string-name>
            <surname>Gurel</surname>
          </string-name>
          , G.:
          <article-title>Porcelain Laminate Veneers: Minimal Tooth Preparation by Design</article-title>
          .
          <source>Dent. Clin. North. Am</source>
          .
          <volume>51</volume>
          ,
          <fpage>419</fpage>
          -
          <lpage>431</lpage>
          (
          <year>2007</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref7">
        <mixed-citation>
          7.
          <string-name>
            <surname>Williams</surname>
            ,
            <given-names>J.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Bennamoun</surname>
            ,
            <given-names>M.</given-names>
          </string-name>
          :
          <article-title>Simultaneous Registration of Multiple Corresponding Point Sets</article-title>
          .
          <source>Comput. Vis. Image. Und</source>
          .
          <volume>81</volume>
          ,
          <fpage>117</fpage>
          -
          <lpage>142</lpage>
          (
          <year>2001</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref8">
        <mixed-citation>
          8.
          <string-name>
            <surname>Mian</surname>
            ,
            <given-names>A.S.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Bennamoun</surname>
            ,
            <given-names>M.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Owens</surname>
          </string-name>
          , R.:
          <article-title>Three-Dimensional Model-Based Object Recognition and Segmentation in Cluttered Scenes</article-title>
          . IEEE.
          <source>T. Pattern. Anal</source>
          .
          <volume>28</volume>
          ,
          <fpage>1584</fpage>
          -
          <lpage>1601</lpage>
          (
          <year>2006</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref9">
        <mixed-citation>
          9.
          <string-name>
            <surname>Davis</surname>
            ,
            <given-names>G.R.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Tayeb</surname>
            ,
            <given-names>R.A.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Seymour</surname>
            ,
            <given-names>K.G.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Cherukara</surname>
            ,
            <given-names>G.P.</given-names>
          </string-name>
          :
          <article-title>Quantification of Residual Dentine Thickness Following Crown Preparation</article-title>
          .
          <source>J. Dent</source>
          .
          <volume>40</volume>
          ,
          <fpage>571</fpage>
          -
          <lpage>576</lpage>
          (
          <year>2012</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref10">
        <mixed-citation>
          10. van Noort,
          <string-name>
            <surname>R.</surname>
          </string-name>
          :
          <source>The Future of Dental Devices is Digital. Dent. Mater</source>
          .
          <volume>28</volume>
          ,
          <fpage>3</fpage>
          -
          <lpage>12</lpage>
          (
          <year>2012</year>
          )
        </mixed-citation>
      </ref>
    </ref-list>
  </back>
</article>