<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Archiving and Interchange DTD v1.0 20120330//EN" "JATS-archivearticle1.dtd">
<article xmlns:xlink="http://www.w3.org/1999/xlink">
  <front>
    <journal-meta />
    <article-meta>
      <title-group>
        <article-title>Persuasion for In-home Technology Intervened Healthcare of Chronic Disease: Case of Diabetes Type 2</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Sakib Jalil</string-name>
          <email>sakib.jalil@my.jcu.edu.au</email>
          <xref ref-type="aff" rid="aff0">0</xref>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>James Cook Drive</institution>
          ,
          <addr-line>Douglas, QLD 4811</addr-line>
          ,
          <country country="AU">Australia</country>
        </aff>
        <aff id="aff1">
          <label>1</label>
          <institution>School of Business (Information Technology), James Cook University</institution>
        </aff>
      </contrib-group>
      <abstract>
        <p>Currently the world is going through a demographic shift that projects the proportion of ageing population will be more than double in the next four decades. This has serious consequences for our current healthcare systems for the ageing population that are prone to chronic diseases. One possible solution is to provide in-home assisted healthcare through technology intervened approaches. This will also create a change of roles, with the patient having more responsibility for their own well-being. However, through investigations of clinical trials of in-home technology intervened healthcare this paper identifies problems of technology use among patients. This paper argues that persuasive technology can help to motivate patients and support quality and cost-effective in-home healthcare. Focusing on diabetes type 2 as a representative of chronic disease, this paper describes background research and explores the possibility of deploying persuasive technology to support in-home technology intervened healthcare.</p>
      </abstract>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>1 Introduction</title>
      <p>
        Over the next four decades the baby boomer population of the world will be retiring
and ageing, while the proportion of working population comparatively decreases. In
the United States the current ageing population is approximately 8% which will rise
up to 17% by the year 2050 [
        <xref ref-type="bibr" rid="ref1">1</xref>
        ]. In Australia this rise will be from 13% to 25% by
2056 [
        <xref ref-type="bibr" rid="ref2">2</xref>
        ]. Chronic illnesses such as diabetes, heart disease, COPD (Chronic Obtrusive
Pulmonary Disease), obesity, etc. are more common in the ageing population, so
hospital visits will increase. However, the demographic shift negatively impacts the
patient/doctor, patient/nurse and patient/hospital bed ratios which will impose a huge
demand on the healthcare system. In addition, high-rising costs of treatments and
hospitalization raises questions of economic feasibility for healthcare of the future
population.
      </p>
      <p>
        One potential solution for the healthcare problem is in-home technology intervened
treatment. These treatments expect patients to have a more proactive role as opposed
to the traditional healthcare system [
        <xref ref-type="bibr" rid="ref3">3</xref>
        ]. However, even if patients are provided with
1 This research is conducted with Trina Myers, Ian Atkinson and Tim Marsh. Special thanks to
      </p>
      <p>Tim Marsh for feedback on this paper.
the latest state-of-the-art technology at home, if they don’t use them, in-home
healthcare technologies will not serve the predicted healthcare crisis.</p>
      <p>This paper investigates whether persuasive technology can assist in the future
healthcare to keep patients committed to their in-home treatment plan. It describes the
early investigations around clinical trials of technology intervened treatments to
explore the feasibility of using persuasive. In this early stage this research aims to
answer the following questions, however in future it will tailor research questions
specifically around ageing factors and persuasion for elderly.</p>
      <p>(1)
(2)</p>
      <p>What are the factors that influence motivation, ability and trigger for
diabetes in-home technology intervened treatments?
How to keep patients motivated in self-monitoring with technology
intervened healthcare (and prevent dropouts)?</p>
    </sec>
    <sec id="sec-2">
      <title>2 Background</title>
      <p>
        Published literature on in-home technology intervened healthcare identifies the main
areas as telemedicine and telehealth [
        <xref ref-type="bibr" rid="ref4">4</xref>
        ], ehealth [
        <xref ref-type="bibr" rid="ref5">5</xref>
        ] and mhealth [
        <xref ref-type="bibr" rid="ref6 ref7">6, 7</xref>
        ]. Design and
assessment of these technologies generally comes from two main areas: HCI
(HumanComputer Interaction) and clinical trails. In HCI, technology is designed, developed
and evaluated using user-centered design approaches, whereas, in medical science a
new technology goes through rigorous testing in clinical trials with the focus on
efficacy to improve medical conditions.
      </p>
      <p>Our investigation of twenty-four clinical trials shows that there are
dropouts/withdrawals from every clinical trial – refer to Table 1 for a list of examples.
The main reason for dropout from a HCI perspective is motivation. A secondary
reason for dropout is lack of time to use the technology. Dropout/withdrawal in the
trials raises the possibility of more dropouts in real world practice. This raises the
question identified in research question (2): How to prevent dropouts?</p>
      <p>
        Fogg’s (2002) seminal work on persuasion describes motivation, ability and trigger
as the three parameters to change a behavior. Intille (2008) further reviewed that there
are four components to an effective just-in-time information through (i) a simple,
tailored message easy to understand, (ii) at an appropriate time (iii) at an appropriate
place (iv) and using a non-irritating strategy. There are seven persuasive tools [
        <xref ref-type="bibr" rid="ref8">8</xref>
        ] that
can guide designers to approach the target behavior including, tunneling technology,
tailoring technology, surveillance technology. Framework for Persuasive Design
System (PSD) provides theory and methods for analyzing persuasive contents [
        <xref ref-type="bibr" rid="ref21">21</xref>
        ].
      </p>
    </sec>
    <sec id="sec-3">
      <title>3 Persuasion for In-home Technology Intervened Diabetes Care</title>
      <p>
        Our investigations found several behavioral changes of in-home technology
intervened healthcare. For example, Meneghini et al. (1998) reported patients to be an
active participant and got involved in metabolic control. Glasgow and Toobert 2000
found improvement in dietary behavior of the patients. Similarly Levetan et al. (2002)
reported improvement in awareness for reaching better health among all of his 150
type 2 diabetes patients, with an intervention inclusive of a goal followed by a phone
call [
        <xref ref-type="bibr" rid="ref12">12</xref>
        ]. All of these results unveil a promising fact that if persuasion techniques are
added, there could be more benefits to change patient behaviors for in-home
treatment.
      </p>
      <p>Author Type of in-home technology
Rutten et al. 1990 Handheld portable self-monitored</p>
      <p>devices
Izquierdo et One-on-one tele conferencing to
al.2003 educate patients
Meneghini et al. Touch-tone data entry – follow up
1998 counseling via voice messages
Piette et al. 2000 Automated telephone disease</p>
      <p>management
Glasgow &amp; Toobert Interactive touch screen CD ROM
2000 with immediate personalized data
Tsang et al. 2001 Handheld electronic diary connected</p>
      <p>to a telephone line
Mckay et al. 2002 Internet based self-management</p>
      <p>
        Utilizing some of Fogg’s persuasive tools, these behaviors could be influenced and
motivation could be improved to reach diabetes blood-sugar goal and better
management of diabetes. For example, tunneling technology [
        <xref ref-type="bibr" rid="ref8">8</xref>
        ] or guided persuasion
could be deployed through a CD ROM or an online interactive video tutorial, where
the interaction comes through scrolling and answering questions, or preferably a
touchpad screen. This could be added in the orientation program for diabetes that a
patient goes through during registration or visiting the clinician. The patient would go
through the experience of what are the conditions they have to look out for, why they
are necessary to look out for, how to do things in which time and how to cooperate
with clinicians in time. Thus, a patient could be exposed and educated to many of the
diabetes management methods which otherwise would have been difficult to deliver.
      </p>
      <p>
        Generally diabetes patients are given a common guideline to follow at home and
these are only customized during a visit with clinician. Information relevant to
individual patient´s blood sugar and patient-specific steps to follow for the day could
be provided through tailoring technology. Surveillance technology [
        <xref ref-type="bibr" rid="ref8">8</xref>
        ] has a promise
in diabetes in-home technology intervened healthcare because clinical trials have
shown that just being enrolled in an in-home technology intervened healthcare
program for example Biermann et al. (2000), some patients have improved their
attitude and medical conditions, which they reported as a hawthorne effect [
        <xref ref-type="bibr" rid="ref19">19</xref>
        ].
      </p>
      <p>
        Since a change in target behavior need motivation, ability and trigger as the three
parameters[
        <xref ref-type="bibr" rid="ref8">8</xref>
        ] , for diabetes in-home patients, this trigger could be a just-in-time sms
or automated telephone call that makes them committed to the self-monitoring and
send blood glucose data to the clinicians.
In order to work with real diabetes patients this research will work in conjunction
with a clinical trial that is being conducted in Townsville, Northern Queensland by
TMML (Townsville-Mackay Medicare Local). TMML is an independent,
not-forprofit organization committed to providing quality evidence based aged care
education and resources to facilitate integration in aged care [
        <xref ref-type="bibr" rid="ref20">20</xref>
        ]. This pilot study
employs tablet PC to better educate and manage diabetes type 2 patients and in-home
technology intervened healthcare through which patients can connect to their
clinicians.
      </p>
      <p>Work will be carried out with the clinical trial subjects (patients) but from an HCI
perspective. A combination of instruments (observation, questionnaire and interview)
will be used with the patients to identify barriers that make them lose interest.
Consecutively causes of frustration, age and ageing factors, lack of time to use it,
motivational factors and behavioral effects of the technology will be investigated. It is
anticipated that different forms of motivation, ability and triggers of diabetes patients
will be identified and proposed. Next, follows the design and implementation of
appropriate forms of trigger(s) and finally, follow-on testing of prototypes in studies
carried with the patients.</p>
    </sec>
    <sec id="sec-4">
      <title>5 Discussion and Conclusion</title>
      <p>Preliminary investigations suggest that persuasive technology is promising to change
behavior in patients with in-home technology intervened treatments. Particularly for
the reason that the technologies investigated did not have a persuasive design
consideration, yet they had behavioral positive changes to affect the well-being. So
persuasion is believed to help patients to keep motivated in using.</p>
      <p>But there are challenges such as identifying the just-in-time trigger, intruding
patient privacy especially in the case of surveillance technology where some patients
may find it bothersome. Designing the right trigger for diabetes patients requires more
research to be done with real subjects during the clinical trials.</p>
      <p>It is known that not all discoveries get a chance to be used in healthcare unless it
passes through a clinical trial. The significance and difference of this research is,
unlike most studies done with few users, this research will work side-by-side with real
diabetes type 2 patients participating in a clinical trial, but from an HCI perspective.
As it matures, it would formulate research questions to guide the investigations
towards making a clear contribution to persuasive technology research.</p>
      <p>The demographic shift is causing a paradigm shift in the healthcare delivery model
to increase in-home technology intervened healthcare. These will be more successful
through persuasive technology. Even though we have the technology, whether people
are ready to accept this paradigm shift in healthcare is one highly topical question.
This paper presents the promise of persuasive technology to influence patients with
increased motivation to use such treatments. This research is still in the beginning
phases and has considered the possible work areas and their challenges.</p>
    </sec>
  </body>
  <back>
    <ref-list>
      <ref id="ref1">
        <mixed-citation>
          1.
          <string-name>
            <given-names>United</given-names>
            <surname>States Census Bureau</surname>
          </string-name>
          , http://www.census.gov/ipc/www/idbpyr.html
        </mixed-citation>
      </ref>
      <ref id="ref2">
        <mixed-citation>2. Australian Bureau of Statistics, http://www.abs.gov.au</mixed-citation>
      </ref>
      <ref id="ref3">
        <mixed-citation>
          3.
          <string-name>
            <surname>Bardram</surname>
            ,
            <given-names>J.E.</given-names>
          </string-name>
          :
          <article-title>Pervasive healthcare as a scientific discipline</article-title>
          .
          <source>Methods of Information in Medicine</source>
          <volume>47</volume>
          ,
          <fpage>178</fpage>
          -
          <lpage>185</lpage>
          (
          <year>2008</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref4">
        <mixed-citation>
          4.
          <string-name>
            <surname>Sood</surname>
            ,
            <given-names>S.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Mbarika</surname>
            ,
            <given-names>V.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Jugoo</surname>
            ,
            <given-names>S.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Dookhy</surname>
            ,
            <given-names>R.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Doarn</surname>
            ,
            <given-names>C.R.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Prakash</surname>
            ,
            <given-names>N.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Merrell</surname>
            ,
            <given-names>R.C.</given-names>
          </string-name>
          :
          <article-title>What is telemedicine? A collection of 104 peer-reviewed perspectives and theoretical underpinnings</article-title>
          .
          <source>Telemedicine and e-Health</source>
          <volume>13</volume>
          ,
          <fpage>573</fpage>
          -
          <lpage>590</lpage>
          (
          <year>2007</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref5">
        <mixed-citation>
          5.
          <string-name>
            <surname>Eysenbach</surname>
          </string-name>
          , G.:
          <article-title>What is e-health?</article-title>
          <source>Journal of medical internet research 3</source>
          , (
          <year>2001</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref6">
        <mixed-citation>
          6.
          <string-name>
            <surname>Elwood</surname>
            ,
            <given-names>D.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Diamond</surname>
            ,
            <given-names>M.C.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Heckman</surname>
            ,
            <given-names>J.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Bonder</surname>
            ,
            <given-names>J.H.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Beltran</surname>
            ,
            <given-names>J.E.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Moroz</surname>
            ,
            <given-names>A.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Yip</surname>
          </string-name>
          , J.: Mobile Health:
          <article-title>Exploring Attitudes Among Physical Medicine and Rehabilitation Physicians Toward this Emerging Element of Health Delivery</article-title>
          .
          <source>PM&amp;R</source>
          <volume>3</volume>
          ,
          <fpage>678</fpage>
          -
          <lpage>680</lpage>
          (
          <year>2011</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref7">
        <mixed-citation>
          7.
          <string-name>
            <surname>Istepanian</surname>
            ,
            <given-names>R.S.H.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Jovanov</surname>
            ,
            <given-names>E.</given-names>
          </string-name>
          , Zhang, Y.:
          <article-title>Guest editorial introduction to the special section on m-health: Beyond seamless mobility and global wireless health-care connectivity</article-title>
          .
          <source>Information Technology in Biomedicine, IEEE Transactions on 8</source>
          ,
          <fpage>405</fpage>
          -
          <lpage>414</lpage>
          (
          <year>2004</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref8">
        <mixed-citation>
          8.
          <string-name>
            <surname>Fogg</surname>
            ,
            <given-names>B.J.:</given-names>
          </string-name>
          <article-title>Persuasive technology: using computers to change what we think and do</article-title>
          .
          <source>Ubiquity</source>
          <year>2002</year>
          ,
          <volume>5</volume>
          (
          <year>2002</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref9">
        <mixed-citation>
          9.
          <string-name>
            <surname>Intille</surname>
            ,
            <given-names>S.S.:</given-names>
          </string-name>
          <article-title>A new research challenge: persuasive technology to motivate healthy aging</article-title>
          .
          <source>Information Technology in Biomedicine, IEEE Transactions on 8</source>
          ,
          <fpage>235</fpage>
          -
          <lpage>237</lpage>
          (
          <year>2004</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref10">
        <mixed-citation>
          10.
          <string-name>
            <surname>Meneghini</surname>
            ,
            <given-names>L.F.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Albisser</surname>
            ,
            <given-names>A.M.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Goldberg</surname>
            ,
            <given-names>R.B.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Mintz</surname>
            ,
            <given-names>D.H.:</given-names>
          </string-name>
          <article-title>An electronic case manager for diabetes control</article-title>
          .
          <source>Diabetes care 21</source>
          ,
          <fpage>591</fpage>
          -
          <lpage>596</lpage>
          (
          <year>1998</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref11">
        <mixed-citation>
          11.
          <string-name>
            <surname>Glasgow</surname>
            ,
            <given-names>R.E.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Toobert</surname>
            ,
            <given-names>D.J.</given-names>
          </string-name>
          :
          <article-title>Brief, computer-assisted diabetes dietary self-management counseling: effects on behavior, physiologic outcomes, and quality of life</article-title>
          .
          <source>Medical care 38</source>
          ,
          <fpage>1062</fpage>
          -
          <lpage>1073</lpage>
          (
          <year>2000</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref12">
        <mixed-citation>
          12.
          <string-name>
            <surname>Levetan</surname>
            ,
            <given-names>C.S.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Dawn</surname>
            ,
            <given-names>K.R.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Robbins</surname>
            ,
            <given-names>D.C.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Ratner</surname>
          </string-name>
          , R.E.:
          <article-title>Impact of computer-generated personalized goals on HbA1c</article-title>
          .
          <source>Diabetes care 25</source>
          ,
          <fpage>2</fpage>
          -
          <lpage>8</lpage>
          (
          <year>2002</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref13">
        <mixed-citation>
          13.
          <string-name>
            <surname>Rutten</surname>
          </string-name>
          , G.,
          <string-name>
            <surname>Van Eijk</surname>
            ,
            <given-names>J.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>de Nobel</surname>
          </string-name>
          , E.,
          <string-name>
            <surname>Beek</surname>
            ,
            <given-names>M.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Van der Velden</surname>
          </string-name>
          , H.:
          <article-title>Feasibility and effects of a diabetes type II protocol with blood glucose self-monitoring in general practice</article-title>
          .
          <source>Family practice 7</source>
          ,
          <fpage>273</fpage>
          -
          <lpage>278</lpage>
          (
          <year>1990</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref14">
        <mixed-citation>
          14.
          <string-name>
            <surname>Izquierdo</surname>
            ,
            <given-names>R.E.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Knudson</surname>
          </string-name>
          , P.E., Meyer, S.,
          <string-name>
            <surname>Kearns</surname>
            ,
            <given-names>J.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Ploutz-Snyder</surname>
            ,
            <given-names>R.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Weinstock</surname>
            ,
            <given-names>R.S.:</given-names>
          </string-name>
          <article-title>A comparison of diabetes education administered through telemedicine versus in person</article-title>
          .
          <source>Diabetes care 26</source>
          ,
          <fpage>1002</fpage>
          -
          <lpage>1007</lpage>
          (
          <year>2003</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref15">
        <mixed-citation>
          15.
          <string-name>
            <surname>Piette</surname>
            ,
            <given-names>J.D.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Weinberger</surname>
            ,
            <given-names>M.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>McPhee</surname>
            ,
            <given-names>S.J.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Mah</surname>
            ,
            <given-names>C.A.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Kraemer</surname>
            ,
            <given-names>F.B.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Crapo</surname>
            ,
            <given-names>L.M.:</given-names>
          </string-name>
          <article-title>Do automated calls with nurse follow-up improve self-care and glycemic control among vulnerable patients with diabetes</article-title>
          ?
          <source>American Journal of Medicine</source>
          <volume>108</volume>
          ,
          <fpage>20</fpage>
          -
          <lpage>27</lpage>
          (
          <year>2000</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref16">
        <mixed-citation>
          16.
          <string-name>
            <surname>Tsang</surname>
            ,
            <given-names>M.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Mok</surname>
            ,
            <given-names>M.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Kam</surname>
            ,
            <given-names>G.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Jung</surname>
            ,
            <given-names>M.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Tang</surname>
            ,
            <given-names>A.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Chan</surname>
            ,
            <given-names>U.</given-names>
          </string-name>
          :
          <article-title>Improvement in diabetes control with a monitoring system based on a hand-held, touch-screen electronic diary</article-title>
          .
          <source>Journal of Telemedicine and Telecare</source>
          <volume>7</volume>
          ,
          <fpage>47</fpage>
          -
          <lpage>50</lpage>
          (
          <year>2001</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref17">
        <mixed-citation>
          17.
          <string-name>
            <surname>McKay</surname>
            ,
            <given-names>H.G.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Glasgow</surname>
            ,
            <given-names>R.E.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Feil</surname>
            ,
            <given-names>E.G.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Boles</surname>
            ,
            <given-names>S.M.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Barrera</surname>
            <given-names>Jr</given-names>
          </string-name>
          ,
          <string-name>
            <surname>M.</surname>
          </string-name>
          :
          <article-title>Internet-based diabetes self-management and support: Initial outcomes from the Diabetes Network project</article-title>
          .
          <source>Rehabilitation Psychology</source>
          <volume>47</volume>
          ,
          <issue>31</issue>
          (
          <year>2002</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref18">
        <mixed-citation>
          18.
          <string-name>
            <surname>Biermann</surname>
            ,
            <given-names>E.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Dietrich</surname>
            ,
            <given-names>W.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Standl</surname>
          </string-name>
          , E.:
          <article-title>Telecare of diabetic patients with intensified insulin therapy</article-title>
          .
          <source>Stud Health Technol Inform</source>
          <volume>77</volume>
          ,
          <fpage>327</fpage>
          -
          <lpage>332</lpage>
          (
          <year>2000</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref19">
        <mixed-citation>
          19.
          <string-name>
            <surname>Azar</surname>
            ,
            <given-names>M.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Gabbay</surname>
          </string-name>
          , R.:
          <article-title>Web-based management of diabetes through glucose uploads: Has the time come for telemedicine? diabetes research</article-title>
          and
          <source>clinical practice 83</source>
          ,
          <fpage>9</fpage>
          -
          <lpage>17</lpage>
          (
          <year>2009</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref20">
        <mixed-citation>20. Townsville Mackay Medicare Local, http://www.tmml.com.au/</mixed-citation>
      </ref>
      <ref id="ref21">
        <mixed-citation>
          21.
          <string-name>
            <surname>Oinas-Kukkonen</surname>
            ,
            <given-names>H.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Harjumaa</surname>
            ,
            <given-names>M.</given-names>
          </string-name>
          :
          <article-title>Persuasive systems design: Key issues, process model, and system features</article-title>
          .
          <source>Communications of the Association for Information Systems</source>
          <volume>24</volume>
          ,
          <issue>28</issue>
          (
          <year>2009</year>
          )
        </mixed-citation>
      </ref>
    </ref-list>
  </back>
</article>