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    <journal-meta />
    <article-meta>
      <title-group>
        <article-title>The Human Behaviour-Change Project: Developing a Behaviour Change Intervention Ontology</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Emma Norris</string-name>
          <email>emma.norris@ucl.ac.uk</email>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Ailbhe Finnerty</string-name>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Marta Marques</string-name>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Robert West</string-name>
          <xref ref-type="aff" rid="aff5">5</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>James Thomas</string-name>
          <xref ref-type="aff" rid="aff4">4</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Pol Mac Aonghusa</string-name>
          <xref ref-type="aff" rid="aff3">3</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Marie Johnston</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Michael P. Kelly</string-name>
          <xref ref-type="aff" rid="aff2">2</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Susan Michie</string-name>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>Aberdeen Health Psychology Group, University of Aberdeen</institution>
          ,
          <country country="UK">UK</country>
        </aff>
        <aff id="aff1">
          <label>1</label>
          <institution>Centre for Behaviour Change, University College London</institution>
          ,
          <country country="UK">UK</country>
        </aff>
        <aff id="aff2">
          <label>2</label>
          <institution>Department of Public Health &amp; Primary Care, University of Cambridge</institution>
          ,
          <country country="UK">UK</country>
        </aff>
        <aff id="aff3">
          <label>3</label>
          <institution>IBM Research, IBM</institution>
          ,
          <addr-line>Dublin</addr-line>
        </aff>
        <aff id="aff4">
          <label>4</label>
          <institution>Institute of Education, University College London</institution>
          ,
          <country country="UK">UK</country>
        </aff>
        <aff id="aff5">
          <label>5</label>
          <institution>Research Department of Behavioural Science &amp; Health, University College London</institution>
          ,
          <country country="UK">UK</country>
        </aff>
      </contrib-group>
      <abstract>
        <p>Behaviour change is essential to improve population health, the selfmanagement of illness, chronic conditions and health professional practice. Evidence about behaviour change interventions is currently being produced at such a rate that manual systems for evidence review and synthesis cannot keep up. Neither can they account for all the relevant features of interventions. The Human Behaviour-Change Project (HBCP) aims to bring together behavioural scientists, computer scientists and system architects to advance progress in behaviour change. It aims to answer variants of the 'big question' of behaviour change: 'What works, compared with what, how well, with what exposure, with what behaviours (for how long), for whom, in what settings, and why?' The main outputs will be: 1) an ontology of behaviour change interventions; 2) an AI system capable of extracting and interpreting evidence from published literature and making predictions; 3) an interface allowing users (researchers, policy-makers, practitioners) to access the knowledge base and answer specific questions about behaviour change.</p>
      </abstract>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>INTRODUCTION</title>
      <p>
        Behaviour change interventions are policies, activities,
services or products designed to cause people to act
differently from how they otherwise would have done
        <xref ref-type="bibr" rid="ref4 ref6">(West &amp;
Michie, 2016)</xref>
        . They involve enabling change amongst
members of the target population (e.g. knowledge, skills,
beliefs, feelings or habits) or their social and/or physical
environment, or both. Typically, the goal is to achieve
change that is sustained over an extended period of time
(such as reducing smoking prevalence in the general
population or increasing levels of habitual physical activity).
      </p>
      <p>
        Knowledge of behaviour change interventions tends to be
fragmented, generated by studies with variable methods and
from partial, unspecified intervention evaluation reports.
Evidence about behaviour change interventions is being
generated at such a high rate that manual systems for
evidence review, interpretation and synthesis cannot keep up
        <xref ref-type="bibr" rid="ref2">(Elliot et al., 2014)</xref>
        . For example, systematic reviews of
health interventions currently take an average of almost 6
years to finish
        <xref ref-type="bibr" rid="ref1">(Bragge et al, 2011)</xref>
        , often making their
results outdated by the time of publication.
      </p>
      <p>Advances in organising the fragmented evidence about
behaviour change interventions are urgently needed to
improve our understanding of behaviour and how to change it.
By accomplishing this we can improve our ability to
develop behaviour change interventions to solve real-world
problems, such as the global burden of disease and unsustainable
climate change.</p>
      <p>
        Recent research has developed a method for specifying
behaviour change interventions in terms of their component
techniques e.g. The Behaviour Change Technique
Taxonomy v1
        <xref ref-type="bibr" rid="ref5">(BCTTv1; Michie et al., 2013)</xref>
        specifies 93 ‘active
ingredients’ of behaviour change interventions. To fully
understand how interventions have their effects, we need to
extend this method of specification to how interventions are
delivered, their reach, the target population and intervention
setting, the target behaviour and the mechanisms of action
of the intervention.
        <xref ref-type="bibr" rid="ref4">(Larsen et al., 2016)</xref>
        . Ontologies, which
are coherent structures for representing knowledge, have
been used to unify many areas of science allied to behaviour
change, such as for mental disorders and mental functioning
        <xref ref-type="bibr" rid="ref3 ref4">(Hastings, 2012; Larsen et al, 2016)</xref>
        . The current
programme of research seeks to develop an ontology of
behaviour change interventions.
1.1
      </p>
      <sec id="sec-1-1">
        <title>Introducing the Human Behaviour-Change Project (HBCP)</title>
        <p>The vision of the Human Behaviour-Change Project
(HBCP; www.humanbehaviourchange.org) is to synthesise
evidence about behaviour change interventions and develop
an automated knowledge system to identify patterns in the
published literature and generate new, up-to-date evidence.
A collaboration of behavioural scientists, computer
scientists and system architects to answer variants of the ‘big
question’ of behaviour change: ‘What works, compared
with what, how well, with what exposure, with what
behaviours (for how long), for whom, in what settings, and why?’
This project involves:
1. Developing an ontology of behaviour change
interventions evaluations: including aspects of intervention
(techniques and delivery), target population, context,
mechanisms of action, behaviours, outcomes, study methods and
reporting features.</p>
        <p>2. Using this ontology to annotate behaviour change
interventions evaluation reports. These annotations will be
used to develop and train an automated system to extract
key information from research reports.</p>
        <p>3. Developing and evaluating Machine Learning and
automated reasoning systems to synthesise and interpret the
annotated evidence and make predictions.</p>
        <p>4. Developing and evaluating an online interface to
interrogate the knowledge base contained within the system.
1.2</p>
      </sec>
      <sec id="sec-1-2">
        <title>Top-level entities of the Behaviour Change Intervention Ontology (BCIO)</title>
        <p>
          To synthesise the fragmented evidence, an essential
element of HBCP is the development of a Behaviour Change
Intervention Ontology (BCIO). At the heart of this ontology
is the ‘behaviour change intervention scenario’ whose
toplevel entities are shown in Figure 1. Each scenario
corresponds to an intervention condition within an evaluation.
 Target Behaviour: behaviour that the intervention
seeks to change (e.g., 6 months of smoking abstinence)
 Intervention: set of policies, activities, services or
products that is intended to result in a difference in the
target behaviour. This includes content
          <xref ref-type="bibr" rid="ref5">(i.e. techniques
used, such as goal-setting or restructuring the physical
environment; Michie et al. 2013)</xref>
          and delivery (i.e who
and what provides the intervention)
 Context: attributes of the target population (e.g aged
16+) and the intevention setting (e.g GP practices)
 Exposure: the extent and nature of the target
population’s access to, receipt of, and engagement with the
intervention, including reach (e.g proportion of sample
that was exposed to intervention) and engagement (e.g
extent participants interacted with intervention
components)
 Mechanisms of action: processes by which
intervention influences the target behaviour (e.g., by providing
a cue to action)
 Outcome: the property of the target behaviour in the
given scenario (e.g., 25%)
 Effect: an estimate of the comparison between the
outcomes in the evaluated scenarios (i.e. each pair of
intervention conditions)
Fig 1. Top-level of Behaviour Change Intervention Ontology
scenario and their putative interactions
        </p>
      </sec>
    </sec>
    <sec id="sec-2">
      <title>ACKNOWLEDGEMENTS</title>
      <p>This project is funded by the Wellcome Trust (UK). Thanks
to Janna Hastings and Julian Everett for their consultancy
work on this project.</p>
    </sec>
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  <back>
    <ref-list>
      <ref id="ref1">
        <mixed-citation>
          <string-name>
            <surname>Bragge</surname>
            ,
            <given-names>P.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Clavisi</surname>
            ,
            <given-names>O.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Turner</surname>
            ,
            <given-names>T.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Tavender</surname>
            ,
            <given-names>E.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Collie</surname>
            ,
            <given-names>A.</given-names>
          </string-name>
          , &amp;
          <string-name>
            <surname>Gruen</surname>
            ,
            <given-names>R.L.</given-names>
          </string-name>
          (
          <year>2011</year>
          ).
          <article-title>The Global Evidence Mapping Initiative: scoping research in broad topic areas</article-title>
          .
          <source>BMC Medical Research Methodology</source>
          .
          <volume>11</volume>
          ,
          <fpage>92</fpage>
          .
        </mixed-citation>
      </ref>
      <ref id="ref2">
        <mixed-citation>
          <string-name>
            <surname>Elliot</surname>
            ,
            <given-names>J.H</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Turner</surname>
            ,
            <given-names>T.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Clavisi</surname>
            ,
            <given-names>O.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Thomas</surname>
            ,
            <given-names>J.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Higgins</surname>
            ,
            <given-names>J.P.T</given-names>
          </string-name>
          , Mabergames,
          <string-name>
            <given-names>C.</given-names>
            &amp;
            <surname>Gruen</surname>
          </string-name>
          ,
          <string-name>
            <surname>R.L.</surname>
          </string-name>
          (
          <year>2014</year>
          ).
          <article-title>Living Systematic Reviews: An Emerging Opportunity to Narrow the Evidence-Practice Gap</article-title>
          .
          <source>PLOS Medicine</source>
          ,
          <volume>11</volume>
          (
          <issue>2</issue>
          ),
          <year>e1001603</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref3">
        <mixed-citation>
          <string-name>
            <surname>Hastings</surname>
            ,
            <given-names>J.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Smith</surname>
            ,
            <given-names>B.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Ceusters</surname>
            ,
            <given-names>W.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Jensen</surname>
            ,
            <given-names>N.</given-names>
          </string-name>
          &amp;
          <string-name>
            <surname>Mulligan</surname>
            ,
            <given-names>K.</given-names>
          </string-name>
          (
          <year>2012</year>
          ).
          <article-title>Representing mental functioning: Ontologies for mental health and disease</article-title>
          .
          <source>ICBO</source>
          <year>2012</year>
          : 3rd International Conference on Biomedical Ontology.
        </mixed-citation>
      </ref>
      <ref id="ref4">
        <mixed-citation>
          <string-name>
            <surname>Larsen</surname>
            ,
            <given-names>K.R.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Michie</surname>
            ,
            <given-names>S.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Hekler</surname>
            ,
            <given-names>E.B.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Gibson</surname>
            ,
            <given-names>B.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Spruijt-Metz</surname>
            ,
            <given-names>D.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Ahern</surname>
            ,
            <given-names>D.</given-names>
          </string-name>
          ,…Moser,
          <string-name>
            <surname>R.P.</surname>
          </string-name>
          (
          <year>2016</year>
          ).
          <article-title>Behavior change interventions: the potential of ontologies for advancing science and practice</article-title>
          .
          <source>Journal of Behavioral Science</source>
          ,
          <volume>40</volume>
          (
          <issue>6</issue>
          ),
          <fpage>1</fpage>
          -
          <lpage>17</lpage>
          .
        </mixed-citation>
      </ref>
      <ref id="ref5">
        <mixed-citation>
          <string-name>
            <surname>Michie</surname>
            ,
            <given-names>S.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Richardson</surname>
            ,
            <given-names>M.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Johnston</surname>
            ,
            <given-names>M.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Abraham</surname>
            ,
            <given-names>C.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Francis</surname>
            ,
            <given-names>J.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Hardeman</surname>
          </string-name>
          , W…,.
          <string-name>
            <surname>Wood</surname>
            ,
            <given-names>C.</given-names>
          </string-name>
          (
          <year>2013</year>
          ).
          <article-title>The Behaviour Change Techniques Taxonomy (v1) of 93 hierarchically clustered techniques: building an international consensus for the reporting of behavior change interventions</article-title>
          .
          <source>Annals of Behavioral Medicine</source>
          ,
          <volume>46</volume>
          (
          <issue>1</issue>
          ),
          <fpage>81</fpage>
          -
          <lpage>95</lpage>
          .
        </mixed-citation>
      </ref>
      <ref id="ref6">
        <mixed-citation>
          <string-name>
            <surname>West</surname>
            ,
            <given-names>R.</given-names>
          </string-name>
          and
          <string-name>
            <surname>Michie</surname>
            ,
            <given-names>S.</given-names>
          </string-name>
          (
          <year>2016</year>
          ).
          <article-title>A guide to development and evaluation of digital behavior change interventions in healthcare</article-title>
          . London: Silverback Publishers.
        </mixed-citation>
      </ref>
    </ref-list>
  </back>
</article>