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  <front>
    <journal-meta />
    <article-meta>
      <title-group>
        <article-title>Analysis of patient domestic activity in recovery from Hip or Knee replacement surgery: modelling wrist-worn wearable RSSI and Accelerometer data in the wild</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Mike Holmes</string-name>
          <email>mike.holmes@bristol.ac.uk</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Hao Song</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Emma Tonkin</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Miquel Perello Nieto</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Sabrina Grant</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Peter Flach</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>University of Bristol</institution>
        </aff>
      </contrib-group>
      <abstract>
        <p>The UK health service sees around 160,000 total hip or knee replacements every year and this number is expected to rise. Expectations of surgical outcome are changing alongside demographic trends, whilst aftercare may be fractured as a result of resource limitation or other factors. Conventional assessments of health outcomes must evolve to keep up with these changing trends. In practice, patients may visit a health care professional to discuss recovery and will provide survey feedback to clinicians using standardised instruments, such as the Oxford Hip &amp; Knee score, in the months following surgery. To aid clinicians in providing accurate assessment of patient recovery a continuous home health care monitoring system would be beneficial. In this paper the authors explore how the SPHERE sensor network can be used to automatically generate measures of recovery from arthroplasty to facilitate continuous monitoring of behaviour, including location, room transitions, movement and activity; in terms of frequency and duration; in a domestic environment. The authors present a case study of data collected from a home equipped with the SPHERE sensor network. Machine learning algorithms are applied to a week of continuous observational data to generate insights into the domestic routine of the occupant. Testing of models shows that location and activity are classified with 86% and 63% precision, respectively.</p>
      </abstract>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>-</title>
      <p>The UK health service sees around 160,000 hip and knee
replacements every year [National Joint Registry, 2018] within
the National Health Service and this number is expected to
increase. Hence, innovative approaches to evaluating
surgical outcomes will be needed to respond to the increasing
burden of joint replacement surgery. Health care
interventions, such as surgeries, are only part of a patient’s journey.
Expectations of surgical outcome are changing alongside
demographic trends [National Joint Registry Editorial Board,
2017]. Conventional assessments of health outcomes must
evolve to keep up with these changing trends. After joint
replacement, up to 30% of patients report minimal
improvement or their symptoms get worse and not all patients are
satisfied with their outcome [Beswick et al., 2012]. Poor
outcomes include continuing pain, functional limitation and
increased health care utilisation. Consequentially, improving
outcomes after joint replacement is a key research priority.</p>
      <p>Patients routinely receive a follow-up appointment
approximately six weeks following surgery. However, this may not
be with the surgeon, but with a registrar. This may
complicate assessments. Various strategies have been proposed
to increase efficiency whilst maintaining quality and patient
acceptability, such as the use of ’virtual clinics’ [Williams,
2014]. These rely on Patient Reported Outcome Measures
(PROMs), such as the Oxford Hip or Oxford Knee Score and
the EQ-5D, a measure of health status. These can assess
various health outcomes including pain, function and aspects of
quality of life, but have sometimes significant limitations. For
example, PROMs may be subjective to a certain extent and
may reflect the patient’s level of pain [Senden et al., 2011;
Stevens-Lapsley et al., 2011].</p>
      <p>Previously, research has explored the relationship between
PROMs and objective measures, notably performance-based
tests such as timed walks or sit-to-stand tests [Bolink et al.,
2012]. Such objective measures are administered in
controlled, laboratory style settings, and may not reflect levels
of activity in daily life. Multimodal sensor systems present
in domestic settings, such as those used in ambient assisted
living scenarios [Rashidi and Mihailidis, 2013], allow
assessment of behaviour and activity in a natural setting.
Establishing a relationship between PROMS and multimodal sensor
data permits us to develop effective methods of passive
monitoring and recovery after surgery, providing a further data
source that, if used alongside PROMS, may allow for
relatively timely intervention in the event of complications,
potentially improving patient outcomes.
1.1</p>
    </sec>
    <sec id="sec-2">
      <title>Contribution</title>
      <p>The contribution of this research is to make an initial
evaluation of statistical method, from literature (section 2), which
may provide measurement or classification of mobility
information including location and room transitions, movement
intensity and distance, and posture &amp; ambulatory activites,
using data gathered in the wild. Techniques detailed in
literature (section 2) are applied to one week of continuous
observational data recorded within a real residence (section 3.1).</p>
      <p>Results of classifier training are presented in section 4,
along with visualisation of measurements and classifications
for location, movement and activity. An evaluation of
methods using real-world data is presented in discussion in section
5, with conclusions in section 6.</p>
      <p>A valuable outcome of this initial evaluative research has
been to highlight the future work (section 7) necessary to
develop algorithms for long-term measurement and
classification which can be robust to the challenges presented when
working with data gathered in the wild.
1.2</p>
    </sec>
    <sec id="sec-3">
      <title>SPHERE: A sensor platform for health care in a residential environment</title>
      <p>SPHERE is an interdisciplinary research project which aims
to develop sensor technologies capable of supporting a
variety of practical use cases, including healthcare and ambient
assisted living outcomes. An additional goal of SPHERE is
to build systems that are considered acceptable by the public
and which are flexible and powerful enough to function well
in a broad variety of domestic environments [Woznowski et
al., 2015; 2017].</p>
      <p>‘Smart home’ systems development has primarily taken
place in laboratory settings[Alam et al., 2012], or, as in the
SPHERE project, in a customised home[Tao et al., 2015].
Research, development and testing of multimodal sensor
technologies was completed in a home owned by the project, the
SPHERE House. In 2017, the SPHERE project began to
deploy a multimodal sensor network into dozens of homes in
the South West of England.</p>
      <p>The work reported here is part of a set of initial studies
on data generated using the SPHERE sensor network in
deployment. In particular, this study is intended to establish the
behaviour of the sensor network and of the associated
analytic infrastructure, including measurements of participant
location, movement and activity, in a genuine deployment
context ‘in the wild’.
2</p>
      <sec id="sec-3-1">
        <title>Related work</title>
        <p>Key indicators of relevance to PROMS include movement
patterns (such as room to room transfers), patterns of
improvement (quality of movement, distance walked, climbing
stairs), activities undertaken (such as cooking or cleaning)
and sleep (e.g. hours sleeping, quality of sleep).</p>
        <p>This study focuses on three measurements of participant
domestic behaviour including location, movement and
activity. In this section, the authors provide a brief overview of
research relating to each method employed.
2.1</p>
      </sec>
    </sec>
    <sec id="sec-4">
      <title>Indoor localisation</title>
      <p>Indoor localisation [Quan et al., 2010; Wang et al., 2014] is
an important area of research for behavioural analysis in
residential health care. The ability to predict the location of a
patient not only gives insight into domestic routine and
habitation, but allows other information to be physically
contextualised. The SPHERE low-energy Bluetooth network provides
a mesh of overlapping or interacting signal strength fields
which provide a pattern of distinct Received Signal Strength
Indicator measures, based on proximity to each receiver in
the network.</p>
      <p>As in literature [Quan et al., 2010; Wang et al., 2014],
RSSI has been used to fingerprint locations within a space
by learning the discriminant RSSI vectors from a moving
average [Quan et al., 2010].
2.2</p>
    </sec>
    <sec id="sec-5">
      <title>Movement</title>
      <p>Measures of movement are often based on either measured
acceleration [Preston et al., 2012; Xiao et al., 2016] or
inferred positional change as represented by shift in Received
Signal Strength Indicator (RSSI) [Krumm and Horvitz, 2004;
Gansemer et al., 2010b; 2010a]. Both approaches have
advantages and disadvantages, considering different types of
movement and the location of the accelerometer. A
wristworn accelerometer as used in SPHERE may show spikes in
magnitude based on ambulation (e.g. walking or running)
but also for rapid hand / arm movements (e.g. chopping
vegetables), and acceleration magnitude may not spikes for low
acceleration positional change (e.g. transcending stairs with
aid of a stair lift). RSSI will highlight positional change
regardless of acceleration but will not show movement that is
non-positional (e.g. walking or running on a tread mill), and
may over overestimate small movements which block line of
sight to RSSI receivers (e.g. rolling over in bed).</p>
      <p>In this work both magnitude and RSSI based movement
calculations are shown for comparison.
2.3</p>
    </sec>
    <sec id="sec-6">
      <title>Activity</title>
      <p>Activity recognition using wearable and mobile devices has
been a major focus for the recent years [Bao and Intille, 2004;
Kwapisz et al., 2011; Siirtola and Ro¨ning, 2012; Ravi et al.,
2005; Janidarmian et al., 2017].</p>
      <p>From a device prospective, mobile phones, smart watches
and wrist bands have the dominant source of data, which
normally captures the acceleration signal around the body of the
users. In this paper we also focus on the 3-axes acceleration
data obtained from a wrist band, which is one of the standard
choice in the field.
3</p>
      <sec id="sec-6-1">
        <title>Case study</title>
        <p>In this study the authors present initial results and data
visualisations for a single case study participant home of the
SPHERE cohort over the first week of system installation.</p>
        <p>The case study presents the authors work in progress in
developing methods of analysis to monitor, visualise and
validate key indicators of recovery from surgery, such as hip or
knee arthroplasty. The experiments in this paper focus on
experimental evaluation of methods for measurement of
movement within the home.
3.1</p>
      </sec>
    </sec>
    <sec id="sec-7">
      <title>Methods</title>
      <p>In this section the authors present an overview of methods
used to generate the three classification metrics: in-door
localisation, movement and activity classification.</p>
    </sec>
    <sec id="sec-8">
      <title>Data Collection</title>
      <p>The case study home has been selected as it represents a
simple use-case for SPHERE technology in the wild. The
residence has a single occupant with few rooms and all rooms
located on the same floor. Figure 1 shows a graphical
representation of the layout of the residence.</p>
      <p>Bedroom 1</p>
      <p>Livingroom 1
Hall 1</p>
      <p>Kitchen 1
Exit</p>
      <p>Bathroom 1
The SPHERE system has been installed in the residence
for five months. In this paper the authors focus on analysis of
the first week of installation, so as to give an overview of the
methods used for analysis and visualisation of data.</p>
      <p>Figure 2 details the physical architecture of one subsystem
of the SPHERE sensor network, the wrist-worn Bluetooth
Low-Energy (BLE) wearable device. The wrist wearable
harbours a tri-axial accelerometer and broadcasts over Bluetooth
at 25Hz.</p>
      <p>Data collected from a second SPHERE subsystem; the
environmental sensor network; will provide passive infra-red
activation data, of use in validating the predictions made
using the wearable data.</p>
      <p>To develop a localisation training set for the home,
during installation of the SPHERE sensor network, a technician
performs an annotation procedure called a ’technician
walkaround’. The technician carries the wearable device to each
room in the home, annotating the start and end times in each
labelled location. The technician walk-around was repeated
prior to the sensor network being removed from the home.
Figure 3 visualises the technician walk around.</p>
      <p>The participant is asked to perform their daily routine in a
fast-forward manner. That is, the participant starts from the
location of the bed, visit corresponding locations according
to their usual routine, while performing simple activities like
“making a cup of tea”. During the experiment, the participant
wears a head mounted camera to record the view, which can
be later annotated for the activities performed.</p>
    </sec>
    <sec id="sec-9">
      <title>Ethics: data collection and publication</title>
      <p>The data used in this study has been collected as part of the
SPHERE project [Woznowski et al., 2015; 2017]. The
participant in this case study has provided consent for data to
be recorded within their home. Participation in the SPHERE
project is voluntary and participants are at liberty to exit the
experiment at any time.</p>
      <p>Due to the sensitive nature of data collected within a
realworld residential environment, data used in this study is not
being made public alongside this paper. A data set of activity
and location annotated SPHERE sensor data, recorded
during short scripted experiments in the SPHERE House (The
SPHERE Challenge) [Twomey et al., 2016], is available
online.</p>
    </sec>
    <sec id="sec-10">
      <title>Classifying location using RSSI fingerprints</title>
      <p>RSSI levels between the wrist-worn wearable and each
installed receiver within the home have been recorded. Using
a 3-second sliding window, a vector of RSSI values is
constructed to represent the position of the participant. For each
second and each gateway, the sum, mean, minimum,
maximum and variance in RSSI are calculated across the second.
Each second in the sliding window was then concatenated to
produce a vector of length n = 75.</p>
      <p>A multi-layer perceptron artificial neural network (MLP)
with three hidden layers, 100 nodes per hidden layer, was
trained to classify the location of the wearable based on RSSI
vectors. To train the classifier, the annotations taken during
the technician walk-around activity (figure 3) were used to
label the training and test set of vectors. The set of labelled
vectors were shuffled and split 50/50 between training and
testing sets. The MLP was trained using the ’adam’ [Kingma
and Lei, 2015] algorithm. Results of training and testing are
presented in the section 4.</p>
      <p>Location predictions are used to visualise room occupancy
over time and to localise movement metrics, providing a view
on where movement happens within the home and at what
times of day.</p>
      <p>In addition, location predictions are used to visualise the
frequency of predicted transition from room to room.
Predicted room transitions are expected to abide by the adjacency
of rooms, as given in the residence layout in figure 1.
(1)</p>
      <p>In this section the authors present initial results applying
localisation, movement and activity classification algorithms to
the first week of data from the case study home.
4.1</p>
    </sec>
    <sec id="sec-11">
      <title>Indoor localisation</title>
    </sec>
    <sec id="sec-12">
      <title>Classifying movement intensity</title>
      <p>Movement intensity is calculated by the magnitude of
acceleration (equation 1), as given by the mean tri-axial
accelerometer readings from the wrist-worn wearable, over a 1-minute
window. This approach has been successfully demonstrated
in [Xiao et al., 2016]. The wearable device transmits
acceleration in x, y and z dimensions at 25Hz.
distance travelled were generated at 1-minute intervals.
Accelerometer based movement: 6,363 accelerometer
magnitude observations were calculated, at 1-minute intervals.
Activity recognition: 302,400 estimates of activity were
generated from RSSI and accelerometer data, at 2-second intervals.
4</p>
      <sec id="sec-12-1">
        <title>Results</title>
        <p>A =qa2x + a2y + az2</p>
        <p>Acceleration magnitude was calculated for each 1-minute
of accelerometer data. For each 1-second window, the
standard deviation of magnitude was calculated. Movement
intensity is here defined as the sum of magnitude standard
deviations (per second) over a given time window.</p>
        <p>Movement is also calculated by the Euclidean distance
between consecutive RSSI vectors. Similarly to the method
described in [Muthukrishnan et al., 2009], an RSSI vector
(sliding window) was calculated for each observation window, in
this case 1-minute. For each 1-minute window, the Euclidean
distance between the current and previous window was
calculated.</p>
        <p>Movement classification is compared to activations of
passive infra-red sensors (PIR) installed in each room of the
residence. PIR sensors activate when movement is detected in
a room. As the case study home is a single occupancy
residence, PIR activations are anticipated to occur inline with
increased acceleration magnitude.</p>
      </sec>
    </sec>
    <sec id="sec-13">
      <title>Classifying activities using RSSI and tri-axial acceleration</title>
      <p>From the fast-forward experiment, three models are obtained
for predicting standing, lay down, and walk with a one-vs-rest
strategy.</p>
      <p>As both the RSSI and acceleration are collected at a
relatively high frequency and hence are not synchronised to each
other, the sliding window (with 2 sconds length) approach has
been applied on the raw signal to obtain the standard feature
vectors.</p>
      <p>Since each activity is only collected for a couple of
seconds during the fast-forward experiment, here we
strategically avoid features that require a higher amount of
training data, leaving features only involving calculating the mean
values, median values, and standard deviations for each
individual acceleration and RSSI, as well as the overall
acceleration and RSSI readings on the target wearable device.</p>
      <p>Regarding the model, we apply the Logistic regression for
obtaining probabilistic outputs, which can then be corrected
via Beta probability calibration.</p>
      <p>With calibrated probabilistic outputs, one can easily
visualise the uncertainty with each prediction, as well as
calculating the overall time spent on these activities.
3.2</p>
    </sec>
    <sec id="sec-14">
      <title>Data</title>
      <p>In this section the authors present a brief overview of the data
generated using methods described in section 3.1.</p>
      <p>Location: 379,234 location classifications were made at 1
second intervals. RSSI based movement: 6,375 estimates of
Figure 4 visualises room occupancy in 2-hour windows, as
predicted by the localisation classifier. Figure 5 shows
location transitions from location to location, within the home.
4.2</p>
    </sec>
    <sec id="sec-15">
      <title>Movement intensity and distance</title>
      <p>As we train the corresponding model for each activity with
the one-vs-rest strategy, the results can be simply evaluated as
in table 3. Table 3 shows test set performance of the classifier.
Figures 10, 11 and 12 show activity classifications aligned to
location classifications (figure 4) across the observed week.
livingroom1
Localisation predictions appear accurate on the small
sample set used for training and testing the classifier. Results
of classifier testing (Table 1) show average precision of 86%
and recall 85% over the five classes. However, given the
limited size of the data set, the assumption of independence
between samples in the training and test set does not hold. For
250
200
that reason, in our current analysis we may expect lower
levels of accuracy than estimated. From the location prediction
data across the week (figure 4), a regular routine emerges.
The participant occupies the bedroom from around 22:00 on
most nights, with occupancy transitioning through the
hallbathroom1
bedroom1
hal 1
room
kitchen1</p>
      <p>livingroom1
way, bathroom, kitchen and living room between 04:00 and
06:00 on most mornings. The participant leaves the residence
between 06:00 and 08:00 between Tuesday and Friday. The
living room is occupied in the evenings between 16:00 and
22:00, with the longest periods of occupancy on the Monday,
Tuesday and Sunday.</p>
      <p>The room transitions (figure 5) show that living room and
kitchen are most frequently moved between. However, the
transition matrix calculated by majority class in each
pairwise minute causes the hallways to be under represented.
Allowing for second order adjacency; essentially allowing for
hops over the hallway; reduces the error.</p>
      <p>Movement intensity (figure 6) by accelerometer magnitude
supports the location predictions, showing that movement
intensity decreases at 22:00 on most days and remains low until
04:00, a time when the participant is located in the bedroom.
The most intense movement within the home was recorded
on the weekend.</p>
      <p>Movement intensity measurements by accelerometer
magnitude are supported by the PIR activation (figure 8) data.
With the exception of the installation period, between 08:00
and 12:00 on Monday, when there were SPHERE technicians
in the home, the individual participants’ movement from the
wearable maps well to the movement detected by the PIR
sensors.</p>
      <p>Movement intensity (accelerometer magnitude) by
location highlights where activity occurs within the home. Table
2 shows that over the entire week the living room was where
most movement occurred, followed by the bedroom, kitchen,
hallway and finally the bathroom.</p>
      <p>Figure 9 shows how movement intensity varied in locations
over time. The visualisation shows low intensity movement
during night time hours, when the participant is located in
the bedroom. More intense movement is detected in both the
kitchen and living room each day in the late afternoon and
evening. The most intense and sustained movement occurred
in the kitchen on Sunday morning.</p>
      <p>A comparison of magnitude measurements in figure 6 and
RSSI measurements in figure 7 during sleeping hours
highlights a potential problem with using RSSI measurement.
RSSI signal change can be by obscuring the wearable.
During sleep the RSSI signals can be modified by a participant
changing sleeping position and obscuring the wearable,
resulting in a perceived movement in position.</p>
      <p>Walking activity, shown in figure 10, appears mostly in the
evening, overlapping with time spent moving in the kitchen
and living room (Figure 6).</p>
      <p>Standing activity, shown in figure 11, occurs in the hall,
kitchen and living room and routinely at the beginning and
end of each day, overlapping with time spent in the kitchen
and living room (figure 4).</p>
      <p>Laying down, shown in figure 12, indicates sleep during
hours of low activity in the bedroom, as shown in figure 6.
6</p>
      <sec id="sec-15-1">
        <title>Conclusions</title>
        <p>The case study has demonstrated that RSSI and tri-axial
accelerometer data can be used to measure key indicators of
recovery from Hip and Knee replacement surgery, such as daily
routine, sleep patterns, location transitions and movement
intensity over a short period of time.</p>
        <p>RSSI fingerprints collected during the technician
walkaround activity were sufficient (Table 1) to model distinct
locations within the home. However, transitions such as kitchen
to bathroom, which appear in figure 5, are not physically
possible according to the layout of the home in figure 1. The
likely cause is the adjacency of kitchen and bathroom
meaning the fingerprints may converge dependent on factors such
as radio-frequency interference.</p>
        <p>To improve the classification algorithm and reduce
erroneous location transitions, a representation of possible
transitions given a prior must be included in the model. This
improvement will be a focus of future work.</p>
        <p>Routine of activity and passivity is highlighted in
movement estimates, with accelerometer magnitude providing the
clearest view of true movement levels. RSSI tended to over
estimate movement.</p>
        <p>Activity classifications, shown in figures 10, 11 and 12,
show a pattern of activity in locations. Laying down occurs
mostly in the bedroom, with standing occurring mostly in the
living room and kitchen, and walking predominantly
occurring in the bedroom and living room. The results suggest that
the method of classification has produced meaningful
activity classifications and should provide a basis for an expanded
activity set in future work.
7</p>
      </sec>
      <sec id="sec-15-2">
        <title>Future work</title>
        <p>In future work, a longer period of observation will be
analysed using methods identified in this paper. It is anticipated
that with a longer period of observation issues such as
concept shift or hardware failure may reduce the effectiveness of
classifiers for periods of time.</p>
        <p>Particularly, the method of RSSI fingerprinting used in this
initial case study would not be robust to hardware failure or
removal. In future work it will be necessary to develop a
continuous retraining strategy, such that should a gateway be
unplugged or suffer failure then location classification can
recover and learn from the new gateway topology.</p>
        <p>SPHERE and HemiSPHERE participants have completed
additional surveys to help with annotation of routine and
behaviour. In analysing a longer time period, future work will
incorporate feedback from a sleep quality survey, daily
diaries and Social Rhythm Metric (SRM).</p>
        <p>We are currently collecting data from additional
participants and pending to apply the same analysis on the collected
data. We need to consider how our current analysis pipeline
generalises to other house layouts, participants and number
of house occupants.</p>
        <p>One possible research direction is about how to validate
the predicted locations when multiple participants are in the
household. In our current analysis it was possible to validate
with the PIR activation.However, we will need to incorporate
different sensors and heuristics to differentiate between the
house occupants.</p>
        <p>In our current work activities are limited to walking, stand
and lay down. In future work, these activities are to be
extended to include sitting down, and climbing and descending
stairs. Further activities are facilitated by additional
annotation of head mounted camera data recorded during the day in
fast-forward activity.</p>
        <p>To further develop a view of domestic routine, data from
smart-meter attached devices such as microwave, toaster,
radio and television will be integrated with participant location
predictions to highlight patterns of user interaction with
domestic appliances.</p>
      </sec>
    </sec>
  </body>
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